{
  "id": 4280,
  "label": "hypothalamic disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002150",
  "properties": {
    "xrefs": [
      "DOID:1931",
      "ICD9:253.9",
      "MEDGEN:6988",
      "MESH:D007027",
      "SCTID:399100005",
      "UMLS:C0020655"
    ],
    "synonyms": [
      "disease of hypothalamus",
      "disease or disorder of hypothalamus",
      "disorder of hypothalamus",
      "hypothalamus disease",
      "hypothalamus disease or disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Neoplastic, inflammatory, infectious, and other diseases of the hypothalamus. Clinical manifestations include appetite disorders; autonomic nervous system diseases; sleep disorders; behavioral symptoms related to dysfunction of the limbic system; and neuroendocrine disorders."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5067,
      "label": "thalamic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4662",
          "MEDGEN:52693",
          "MESH:D013786",
          "NCIT:C85186",
          "UMLS:C0039726"
        ],
        "synonyms": [
          "disease of dorsal plus ventral thalamus",
          "disease or disorder of dorsal plus ventral thalamus",
          "disorder of dorsal plus ventral thalamus",
          "dorsal plus ventral thalamus disease",
          "dorsal plus ventral thalamus disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the thalamus. Causes include brain neoplasms, cerebrovascular disorders, brain trauma, brain hypoxia, infections, and brain hemorrhage. Signs and symptoms include movement and sensory abnormalities, visual abnormalities, ataxia, and coma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003081"
    }
  ],
  "children": [
    {
      "id": 5819,
      "label": "Froelich syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4280,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6676",
          "ICD9:253.8",
          "MEDGEN:4795",
          "NCIT:C34625",
          "SCTID:62999006",
          "UMLS:C0016724"
        ],
        "synonyms": [
          "Babinski-Froelich syndrome",
          "Froehlich's syndrome",
          "Froelich's syndrome",
          "Frohlich syndrome",
          "Frohlich's syndrome",
          "Frolich's syndrome",
          "Fröhlich syndrome",
          "Launois-Cleret syndrome",
          "dystrophia Adiposogenitalis",
          "hypothalamic infantilism-obesity",
          "sexual infantilism",
          "Adiposodysgenesis",
          "Froelich's adiposity",
          "adiposogenital dystrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Froelich syndrome is characterized by obesity and hypogonadism due to a hypothalamic-pituitary disorder. The hypothalamus is a part of the brain where certain functions such as sleep cycles and body temperature are regulated. The pituitary is a gland that makes hormones that affect growth and the functions of other glands in the body. Froehlich syndrome is acquired(i.e., not thought to be inherited or genetic). This syndrome appears to affect males more commonly. The term 'Froelich syndrome' is rarely used today."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003962"
    },
    {
      "id": 8247,
      "label": "hypothalamic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4280,
        20429
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3644",
          "EFO:1000979",
          "MEDGEN:5717",
          "MESH:D007029",
          "NCIT:C3129",
          "SCTID:254968009",
          "UMLS:C0020659",
          "icd11.foundation:1383549237"
        ],
        "synonyms": [
          "hypothalamic neoplasms",
          "hypothalamic tumor",
          "hypothalamic tumour",
          "hypothalamus neoplasm",
          "hypothalamus tumor",
          "hypothalamus tumour",
          "neoplasm of hypothalamus",
          "neoplasm of the hypothalamus",
          "tumor of hypothalamus",
          "tumor of the hypothalamus",
          "tumour of hypothalamus",
          "tumour of the hypothalamus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary or metastatic neoplasm that affects the hypothalamus."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006799"
    },
    {
      "id": 23123,
      "label": "hypothalamic dysfunction",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:155833",
          "SCTID:111568001",
          "UMLS:C0751230"
        ],
        "synonyms": [
          "hypothalamic dysfunction",
          "hypothalamic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hypothalamic dysfunction refers to a condition in which the hypothalamus is not working properly. The hypothalamus produces hormones that control body temperature, hunger, moods, release of hormones from many glands such as the pituitary gland, sex drive, sleep, and thirst. The signs and symptoms patients have vary depending on the hormones missing. A number of different causes including anorexia, bleeding, genetic disorder, tumors, and more have been linked to hypothalamic dysfunction. Treatment depends on the cause of the hypothalamic dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043101"
    }
  ],
  "roots": [
    {
      "id": 5067,
      "label": "thalamic disorder"
    }
  ]
}