{
  "id": 4295,
  "label": "rectum adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002169",
  "properties": {
    "xrefs": [
      "DOID:1996",
      "EFO:0005631",
      "MEDGEN:56214",
      "NCIT:C9383",
      "ONCOTREE:READ",
      "SCTID:254582000",
      "UMLS:C0149978",
      "icd11.foundation:1316028436"
    ],
    "synonyms": [
      "adenocarcinoma - rectum",
      "adenocarcinoma of rectum",
      "adenocarcinoma of the rectum",
      "rectal adenocarcinoma",
      "rectum adenocarcinoma",
      "read"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        21360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050861",
          "DOID:0050913",
          "EFO:0000365",
          "MEDGEN:230816",
          "NCIT:C5105",
          "ONCOTREE:COADREAD",
          "SCTID:408645001",
          "UMLS:C1319315"
        ],
        "synonyms": [
          "adenocarcinoma of large bowel",
          "adenocarcinoma of large intestine",
          "adenocarcinoma of the large bowel",
          "adenocarcinoma of the large intestine",
          "colorectal (colon or rectal) adenocarcinoma",
          "colorectal adenocarcinoma",
          "colorectum adenocarcinoma",
          "large bowel adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005008"
    },
    {
      "id": 23485,
      "label": "rectal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8006,
        21360,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:40100",
          "NCIT:C9382",
          "UMLS:C0007113"
        ],
        "synonyms": [
          "cancer of rectum",
          "cancer of the rectum",
          "rectal cancer",
          "carcinoma of rectum",
          "carcinoma of the rectum",
          "rectal carcinoma",
          "rectum carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas."
      },
      "child_count": 18,
      "reference_id": "MONDO:0044937"
    }
  ],
  "children": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4295,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3447",
          "GARD:0027609",
          "MEDGEN:233976",
          "NCIT:C5600",
          "SCTID:423607006",
          "UMLS:C1332257"
        ],
        "synonyms": [
          "adenocarcinoma of anus",
          "adenocarcinoma of the anus",
          "anal adenocarcinoma",
          "anus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002652"
    },
    {
      "id": 4783,
      "label": "rectum mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4295,
        6700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3709",
          "MEDGEN:83537",
          "NCIT:C7973",
          "UMLS:C0279652"
        ],
        "synonyms": [
          "colloid adenocarcinoma of rectum",
          "colloid adenocarcinoma of the rectum",
          "colloidal adenocarcinoma of rectum",
          "colloidal adenocarcinoma of the rectum",
          "mucinous adenocarcinoma of rectum",
          "mucinous adenocarcinoma of the rectum",
          "rectal colloid adenocarcinoma",
          "rectal colloidal adenocarcinoma",
          "rectal mucinous adenocarcinoma",
          "rectum mucinous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the rectum characterized by the presence of pools of extracellular mucin. Malignant glandular epithelial cells are present in the mucin collections. Mucin constitutes more than 50% of the lesion."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002748"
    },
    {
      "id": 6152,
      "label": "rectal signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4295,
        23338
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7707",
          "MEDGEN:124641",
          "NCIT:C9168",
          "UMLS:C0279654"
        ],
        "synonyms": [
          "rectal signet Ring cell adenocarcinoma",
          "rectum signet ring cell carcinoma",
          "signet Ring adenocarcinoma of rectum",
          "signet Ring adenocarcinoma of the rectum",
          "signet Ring cell adenocarcinoma of rectum",
          "signet Ring cell adenocarcinoma of the rectum",
          "rectum signet ring adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma arising from the rectum. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. These cells constitute more than 50% of the malignant cellular population."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004336"
    },
    {
      "id": 20200,
      "label": "rectal medullary carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4295,
        20193
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:364314",
          "NCIT:C60640",
          "UMLS:C1882915"
        ],
        "synonyms": [
          "rectal medullary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare, invasive rectal adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020801"
    }
  ],
  "roots": [
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma"
    },
    {
      "id": 23485,
      "label": "rectal carcinoma"
    }
  ]
}