{
  "id": 4301,
  "label": "degeneration of macula and posterior pole",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002175",
  "properties": {
    "xrefs": [
      "DOID:2007",
      "ICD10CM:H35.3",
      "ICD9:362.5",
      "MEDGEN:573150",
      "SCTID:267611002",
      "UMLS:C0339436"
    ],
    "synonyms": [
      "degeneration of macula and posterior pole of retina"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 5003,
      "label": "macular degeneration",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6377
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4448",
          "EFO:0009606",
          "MEDGEN:7434",
          "MESH:D008268",
          "NCIT:C123330",
          "SCTID:422338006",
          "UMLS:C0024437"
        ],
        "synonyms": [
          "macula lutea retinal degeneration",
          "macula retinal degeneration",
          "retinal degeneration of macula lutea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003004"
    }
  ],
  "children": [
    {
      "id": 3857,
      "label": "hole retinal cyst",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13214",
          "ICD9:362.54",
          "MEDGEN:687835",
          "SCTID:1079004",
          "UMLS:C1261331"
        ],
        "synonyms": [
          "macular cyst, hole, or pseudohole of retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001663"
    },
    {
      "id": 4091,
      "label": "cystoid macular retinal degeneration",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14245",
          "ICD9:362.53",
          "MEDGEN:472900",
          "SCTID:14046000",
          "UMLS:C0154850"
        ],
        "synonyms": [
          "cystoid macular degeneration of retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001919"
    },
    {
      "id": 4300,
      "label": "preretinal fibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2006",
          "ICD9:362.56",
          "ICD9:362.89",
          "MEDGEN:87388",
          "MESH:D019773",
          "SCTID:367649002",
          "UMLS:C0339543"
        ],
        "synonyms": [
          "macular puckering of retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002174"
    },
    {
      "id": 6658,
      "label": "toxic maculopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9867",
          "ICD10CM:H35.38",
          "ICD9:362.55",
          "MEDGEN:543164",
          "SCTID:44115007",
          "UMLS:C0271086",
          "icd11.foundation:1889317154"
        ],
        "synonyms": [
          "toxic maculopathy of retina"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004904"
    },
    {
      "id": 6874,
      "label": "age-related macular degeneration",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4301,
        19000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10871",
          "EFO:0001365",
          "GARD:0027715",
          "ICD9:362.50",
          "MEDGEN:116576",
          "NCIT:C84391",
          "OMIMPS:603075",
          "Orphanet:279",
          "SCTID:267718000",
          "UMLS:C0242383",
          "birnlex:12812",
          "icd11.foundation:1514301548"
        ],
        "synonyms": [
          "AMD",
          "ARMD",
          "Senile macular retinal degeneration",
          "age-related macular degeneration",
          "macular degeneration, age-related",
          "age related macular degeneration"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005150"
    },
    {
      "id": 8378,
      "label": "retinal drusen",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2569",
          "EFO:1001155",
          "ICD9:362.57",
          "MEDGEN:20549",
          "MESH:D015593",
          "MedDRA:10062776",
          "SCTID:247153005",
          "UMLS:C0035312"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Colloid or hyaline bodies lying beneath the retinal pigment epithelium. They may occur either secondary to changes in the choroid that affect the pigment epithelium or as an autosomal dominant disorder of the retinal pigment epithelium."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006949"
    }
  ],
  "roots": [
    {
      "id": 5003,
      "label": "macular degeneration"
    }
  ]
}