{
  "id": 4318,
  "label": "vulvar squamous neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002195",
  "properties": {
    "xrefs": [
      "DOID:2072",
      "MEDGEN:276998",
      "NCIT:C40283",
      "UMLS:C1520097"
    ],
    "synonyms": [
      "mammalian vulva squamous cell neoplasm",
      "vulvar squamous neoplasm",
      "vulvar squamous tumor",
      "vulvar squamous tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vulva. Representative examples include vestibular papilloma, intraepithelial neoplasia, and squamous cell carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4600,
      "label": "squamous cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3168",
          "MEDGEN:60219",
          "MESH:D018307",
          "NCIT:C3792",
          "UMLS:C0206720"
        ],
        "synonyms": [
          "epidermoid cell neoplasm",
          "epidermoid cell tumor",
          "epidermoid cell tumour",
          "squamous cell neoplasm",
          "squamous cell tumor",
          "squamous cell tumor (qualifier value)",
          "squamous cell tumour",
          "squamous cell tumour (qualifier value)"
        ],
        "definition": "A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example."
      },
      "child_count": 7,
      "reference_id": "MONDO:0002532"
    },
    {
      "id": 20293,
      "label": "vulvar neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4310,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.5",
          "MEDGEN:22689",
          "NCIT:C3443",
          "SCTID:126922007",
          "UMLS:C0042995"
        ],
        "synonyms": [
          "mammalian vulva neoplasm",
          "mammalian vulva neoplasm (disease)",
          "mammalian vulva tumor",
          "mammalian vulva tumour",
          "neoplasm of mammalian vulva",
          "neoplasm of the vulva",
          "neoplasm of vulva",
          "tumor of mammalian vulva",
          "tumor of the vulva",
          "tumor of vulva",
          "tumour of mammalian vulva",
          "tumour of the vulva",
          "tumour of vulva",
          "vulva neoplasm",
          "vulva tumor",
          "vulva tumour",
          "vulval neoplasm",
          "vulvar neoplasm",
          "vulvar tumor",
          "vulvar tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the vulva. Representative examples include Bartholin gland adenoma, vulvar nodular hidradenoma, vulvar carcinoma, and vulvar melanoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0021049"
    }
  ],
  "children": [
    {
      "id": 4317,
      "label": "vestibular papilloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3044,
        4006,
        4318
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2071",
          "MEDGEN:277874",
          "NCIT:C6376",
          "UMLS:C1336982"
        ],
        "synonyms": [
          "mammalian vulva squamous papilloma",
          "vestibular papilloma",
          "vulvar squamous papilloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign papillary neoplasm that arises from the vulva and is characterized by the presence of a delicate fibrovascular stalk lined by squamous epithelium. There is no evidence of epithelial atypia."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002194"
    },
    {
      "id": 6917,
      "label": "vulvar intraepithelial neoplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4318
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002627",
          "GARD:0019876",
          "MEDGEN:91093",
          "NCIT:C4756",
          "Orphanet:137583",
          "UMLS:C0346210"
        ],
        "synonyms": [
          "VIN",
          "intraepithelial neoplasia of the vulva",
          "intraepithelial neoplasia of vulva",
          "squamous vulvar intraepithelial neoplasia",
          "vulva intraepithelial neoplasia",
          "vulval intraepithelial neoplasia",
          "vulvar intraepithelial tumor",
          "vulvar intraepithelial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Intraepithelial neoplasia of the vulvar squamous epithelium. There is no evidence of invasion. This category includes vulvar high grade squamous intraepithelial lesion and vulvar intraepithelial neoplasia, differentiated type."
      },
      "child_count": 1,
      "reference_id": "MONDO:0005198"
    },
    {
      "id": 8097,
      "label": "vulvar seborrheic keratosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4318,
        4707,
        6931,
        9715
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6944",
          "GARD:0024446",
          "MEDGEN:237055",
          "NCIT:C6375",
          "UMLS:C1336981"
        ],
        "synonyms": [
          "mammalian vulva seborrheic keratosis",
          "seborrheic keratosis of mammalian vulva",
          "seborrheic keratosis of the vulva",
          "seborrheic keratosis of vulva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign squamous neoplasm that arises from the vulva. It is characterized by the proliferation of the basal cells in the squamous epithelium, acanthosis, hyperkeratosis, and cysts formation."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006622"
    },
    {
      "id": 21524,
      "label": "vulvar squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4318,
        6823,
        6931
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2101",
          "EFO:1000624",
          "GARD:0022005",
          "MEDGEN:79201",
          "NCIT:C4052",
          "Orphanet:494448",
          "SCTID:254895003",
          "UMLS:C0280856",
          "icd11.foundation:146824338"
        ],
        "synonyms": [
          "epidermoid carcinoma of the vulva",
          "epidermoid carcinoma of vulva",
          "epidermoid cell carcinoma of the vulva",
          "epidermoid cell carcinoma of vulva",
          "mammalian vulva squamous cell carcinoma",
          "squamous cell carcinoma of the vulva",
          "squamous cell carcinoma of vulva",
          "vulva epidermoid carcinoma",
          "vulva epidermoid cell carcinoma",
          "vulva squamous cell carcinoma",
          "vulvar epidermoid carcinoma",
          "vulvar epidermoid cell carcinoma",
          "vulvar squamous cell cancer",
          "vulvar squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)"
      },
      "child_count": 18,
      "reference_id": "MONDO:0024609"
    }
  ],
  "roots": [
    {
      "id": 4600,
      "label": "squamous cell neoplasm"
    },
    {
      "id": 20293,
      "label": "vulvar neoplasm"
    }
  ]
}