{
  "id": 4330,
  "label": "vulval Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002207",
  "properties": {
    "xrefs": [
      "DOID:2097",
      "GARD:0023083",
      "ICD9:233.39",
      "MEDGEN:266154",
      "NCIT:C4027",
      "SCTID:254898001",
      "UMLS:C1275217"
    ],
    "synonyms": [
      "Paget disease of the vulva",
      "Paget's disease of the vulva",
      "Paget's disease of vulva",
      "mammalian vulva Paget disease",
      "vulva Paget's disease",
      "vulval Paget's disease",
      "vulvar Paget's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An uncommon intraepithelial malignant neoplasm of eccrine or apocrine origin, arising from the vulva. It usually affects post-menopausal women. In approximately 10-20% of the cases there is an associated anorectal, or urothelial carcinoma or a skin appendage adenocarcinoma identified. It presents as a red, eczematous lesion. Microscopically, it is characterized by the presence of the typical Paget cells which are large, round cells with abundant cytoplasm and prominent nuclei."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 9488,
      "label": "extramammary Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000249",
          "GARD:0004192",
          "ICDO:8542/3",
          "MEDGEN:45280",
          "MESH:D010145",
          "MedDRA:10033366",
          "MedDRA:10068223",
          "NCIT:C3302",
          "OMIM:167300",
          "ONCOTREE:EMPD",
          "Orphanet:2800",
          "UMLS:C0030186",
          "icd11.foundation:1796624917"
        ],
        "synonyms": [
          "Extramammary Paget's disease",
          "Paget disease Extramammary",
          "Paget's disease of skin",
          "Paget's disease of the skin",
          "Paget's skin disease",
          "extramammary Paget disease",
          "EMPD",
          "Paget disease, EXTRAMAMMARY",
          "cutaneous Paget's disease"
        ],
        "definition": "A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008177"
    },
    {
      "id": 21365,
      "label": "vulvar adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4321,
        6712,
        6931
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2098",
          "GARD:0022007",
          "MEDGEN:234480",
          "NCIT:C6380",
          "Orphanet:494454",
          "UMLS:C1336975"
        ],
        "synonyms": [
          "adenocarcinoma of the vulva",
          "adenocarcinoma of vulva",
          "mammalian vulva adenocarcinoma",
          "vulva adenocarcinoma",
          "vulvar adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the vulva. Representative examples include Bartholin gland adenocarcinoma, eccrine adenocarcinoma, apocrine adenocarcinoma, and sebaceous carcinoma."
      },
      "child_count": 21,
      "reference_id": "MONDO:0024336"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 9488,
      "label": "extramammary Paget disease"
    },
    {
      "id": 21365,
      "label": "vulvar adenocarcinoma"
    }
  ]
}