{
  "id": 4359,
  "label": "coagulation protein disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002242",
  "properties": {
    "xrefs": [
      "DOID:2212",
      "GARD:0023096",
      "MEDGEN:108723",
      "MESH:D020147",
      "NCIT:C27215",
      "SCTID:86075001",
      "UMLS:C0600503"
    ],
    "synonyms": [
      "coagulation factor deficiency",
      "coagulation factor deficiency syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Congenital or acquired deficiency of one of the coagulation factors. It results in bleeding."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 28,
  "parents": [
    {
      "id": 3738,
      "label": "blood coagulation disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1247",
          "EFO:0009314",
          "ICD9:286",
          "ICD9:286.9",
          "ICD9:287.8",
          "MEDGEN:604",
          "MESH:D001778",
          "NCIT:C2902",
          "SCTID:64779008",
          "UMLS:C0005779"
        ],
        "synonyms": [
          "blood coagulation disorder",
          "coagulation defect",
          "coagulation disorder",
          "coagulation disorder, blood",
          "coagulation disorders, blood",
          "coagulopathy",
          "disorder, blood coagulation",
          "disorders, blood coagulation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001531"
    }
  ],
  "children": [
    {
      "id": 4358,
      "label": "factor XIII deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023095",
          "MEDGEN:1385982",
          "MESH:D005177",
          "NANDO:2200681",
          "UMLS:C4316906"
        ],
        "synonyms": [
          "FXIIID"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acquired or inherited coagulation disorder due to reduced levels and activity of factor XIII."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002241"
    },
    {
      "id": 4361,
      "label": "factor VII deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023098",
          "ICD9:286.3",
          "MEDGEN:8769",
          "MESH:D005168",
          "NANDO:2200675",
          "SCTID:37193007",
          "UMLS:C0015503"
        ],
        "synonyms": [
          "F7 deficiency",
          "deficiency, stable",
          "factor 7 deficiency",
          "factor VII deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A coagulation disorder characterized by the partial or complete absence of factor VII activity in the blood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002244"
    },
    {
      "id": 4364,
      "label": "factor X deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023100",
          "MEDGEN:4635",
          "MESH:D005171",
          "NANDO:2200678",
          "NCIT:C131632",
          "SCTID:76642003",
          "UMLS:C0015519"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A coagulation disorder characterized by the partial or complete absence of factor X activity in the blood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002247"
    },
    {
      "id": 9847,
      "label": "thrombophilia due to activated protein C resistance",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        23980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111902",
          "GARD:0024631",
          "ICD9:289.81",
          "MEDGEN:396074",
          "MESH:D020016",
          "OMIM:188055",
          "SCTID:421527008",
          "UMLS:C1861171"
        ],
        "synonyms": [
          "thrombophilia 2 due to activated protein C resistance",
          "thrombophilia due to activated protein C resistance",
          "APC resistance",
          "Activated Protein C resistance",
          "Pccf deficiency",
          "Proc cofactor deficiency",
          "THPH2",
          "resistance, APC",
          "thrombophilia 5",
          "thrombophilia due to ACTIVATED PROTEIN C resistance",
          "thrombophilia due to Factor 5 Leiden",
          "thrombophilia due to deficiency of Activated Protein C cofactor",
          "thrombophilia, susceptibility to, due to factor V Leiden"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008560"
    },
    {
      "id": 10263,
      "label": "hypoplasminogenemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111592",
          "GARD:0004380",
          "ICD9:372.39",
          "MEDGEN:369859",
          "MESH:C580017",
          "MedDRA:10071570",
          "OMIM:217090",
          "Orphanet:722",
          "Orphanet:97231",
          "SCTID:403435005",
          "SCTID:95840007",
          "UMLS:C1968804",
          "icd11.foundation:1240776230"
        ],
        "synonyms": [
          "hypoplasminogenemia",
          "plasminogen deficiency type 1",
          "plasminogen deficiency, type 1",
          "plasminogen deficiency, type I",
          "type 1 plasminogen deficiency",
          "ligneous conjunctivitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare multi-system disease characterized by markedly impaired extracellular fibrinolysis leading to the formation of ligneous (fibrin-rich) pseudomembranes on mucosae."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009009"
    },
    {
      "id": 10477,
      "label": "congenital high-molecular-weight kininogen deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111676",
          "GARD:0002684",
          "ICD9:286.9",
          "MEDGEN:75780",
          "MESH:C537060",
          "NANDO:2200685",
          "NCIT:C98946",
          "OMIM:228960",
          "Orphanet:483",
          "SCTID:27312002",
          "UMLS:C0272340",
          "icd11.foundation:453135247"
        ],
        "synonyms": [
          "high molecular weight kininogen deficiency",
          "kininogen deficiency",
          "Fitzgerald trait",
          "Fitzgerald trait kininogen deficiency, total, included",
          "Flaujeac factor deficiency",
          "Flaujeac trait",
          "Flaujeac trait, included",
          "HMWK",
          "HMWK deficiency",
          "Williams trait",
          "Williams trait, included",
          "high-molecular-weight kininogen deficiency, congenital",
          "kininogen deficiency, high molecular weight",
          "kininogen deficiency, high molecular weight and LOW molecular weight, included",
          "kininogen deficiency, high molecular weight and Low molecular weight",
          "kininogen deficiency, total"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare autosomal recessive inherited disorder characterized by prolonged partial thromboplastin time and absence of bleeding diathesis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009234"
    },
    {
      "id": 10552,
      "label": "congenital factor XII deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2905,
        4359,
        4360,
        10564,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2231",
          "GARD:0006558",
          "ICD9:286.3",
          "MEDGEN:8772",
          "MESH:D005175",
          "NANDO:2200680",
          "NCIT:C131740",
          "NORD:1119",
          "OMIM:234000",
          "Orphanet:330",
          "SCTID:46981006",
          "UMLS:C0015526"
        ],
        "synonyms": [
          "Factor XII Deficiency",
          "Hageman Factor deficiency",
          "congenital Hageman factor deficiency",
          "congenital factor XII deficiency",
          "F12 deficiency",
          "Haf deficiency",
          "coagulation factor 12 deficiency",
          "factor 12 deficiency",
          "factor XII deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital factor XII deficiency is an autosomal recessive systemic dysfunction of the hemostatic pathway, that is due to a defect in the coagulation factor XII (FXII or Hageman factor), and is either asymptomatic or characterized by a prolonged activated partial thromboplastin time and an increased risk for thromboembolism. FXII deficiency is strongly associated with primary recurrent abortions."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009315"
    },
    {
      "id": 11086,
      "label": "alpha-2-plasmin inhibitor deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060601",
          "GARD:0000731",
          "MEDGEN:414178",
          "MESH:C537777",
          "NANDO:2200687",
          "OMIM:262850",
          "Orphanet:79",
          "SCTID:716746003",
          "UMLS:C2752081",
          "icd11.foundation:688627594"
        ],
        "synonyms": [
          "alpha-2-plasmin inhibitor deficiency",
          "plasmin inhibitor deficiency",
          "anti-plasmin deficiency, congenital",
          "antiplasmin deficiency",
          "antiplasmin deficiency, congenital",
          "congenital alpha2-antiplasmin deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital alpha2 antiplasmin deficiency is a rare hemorrhagic disorder caused by congenital deficiency of alpha2 antiplasmin, leading to dysregulated fibrinolysis and is characterized by a hemorrhagic tendency presenting from childhood with prolonged bleeding and ecchymoses following minor trauma and spontaneous bleeding episodes (often in unusual locations like diaphysis of long bones). Congenital alpha2 antiplasmin deficiency is inherited in an autosomal recessive manner."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009883"
    },
    {
      "id": 11284,
      "label": "Tatsumi factor deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024707",
          "MEDGEN:336460",
          "MESH:C564787",
          "OMIM:272650",
          "UMLS:C1848931"
        ],
        "synonyms": [
          "Tatsumi factor deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010097"
    },
    {
      "id": 12711,
      "label": "East Texas bleeding disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017613",
          "MEDGEN:342980",
          "MESH:C565275",
          "OMIM:605913",
          "Orphanet:391320",
          "UMLS:C1853831"
        ],
        "synonyms": [
          "Bdet",
          "bleeding disorder, EAST Texas type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011615"
    },
    {
      "id": 13941,
      "label": "inherited prekallikrein deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        20411,
        23419
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004477",
          "ICD9:286.9",
          "MESH:C562725",
          "NANDO:2200684",
          "OMIM:612423",
          "Orphanet:749"
        ],
        "synonyms": [
          "congenital prekallikrein deficiency",
          "fletcher factor (prekallikrein) deficiency",
          "hereditary prekallikrein deficiency",
          "Fletcher Factor deficiency",
          "PKK deficiency",
          "prekallikrein deficiency",
          "prekallikrein deficiency, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of prekallikrein deficiency that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012901"
    },
    {
      "id": 14263,
      "label": "congenital plasminogen activator inhibitor type 1 deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        10564,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004381",
          "MEDGEN:412870",
          "MESH:C567640",
          "NANDO:2200688",
          "NCIT:C133884",
          "OMIM:613329",
          "Orphanet:465",
          "SCTID:717407006",
          "UMLS:C2750067",
          "icd11.foundation:428643962"
        ],
        "synonyms": [
          "congenital PAI-1 deficiency",
          "congenital plasminogen activator inhibitor type 1 deficiency",
          "hyperfibrinolysis due to Pai1 deficiency",
          "plasminogen activator INHIBITOR-1 deficiency",
          "plasminogen activator inhibitor type 1 deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital plasminogen activator inhibitor type 1 (PAI-1) deficiency is a rare genetic bleeding disorder characterized by premature lysis of hemostatic clots and a moderate bleeding tendency."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013227"
    },
    {
      "id": 14793,
      "label": "thrombomodulin-related bleeding disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        23980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111908",
          "GARD:0017726",
          "MEDGEN:482606",
          "MESH:C566057",
          "OMIM:614486",
          "Orphanet:436169",
          "UMLS:C3280976"
        ],
        "synonyms": [
          "THBD-related bleeding disorder",
          "THBD-related coagulopathy",
          "thrombomodulin-related coagulopathy",
          "thrombophilia 12 due to thrombomodulin defect",
          "THPH12",
          "thrombophilia due to thrombomodulin defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013775"
    },
    {
      "id": 16482,
      "label": "congenital vitamin K-dependent coagulation factors deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        10564,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112172",
          "GARD:0020121",
          "MEDGEN:1378036",
          "OMIMPS:277450",
          "Orphanet:169826",
          "Orphanet:98434",
          "UMLS:C4510617",
          "icd11.foundation:54644599"
        ],
        "synonyms": [
          "congenital vitamin K-dependent coagulation factors combined deficiency",
          "vitamin K-dependent clotting factors, combined deficiency of"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital vitamin K-dependent coagulation factors deficiency involving multiple coagulation factors."
      },
      "child_count": 20,
      "reference_id": "MONDO:0015722"
    },
    {
      "id": 16554,
      "label": "hemorrhagic disease due to alpha-1-antitrypsin Pittsburgh mutation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020148",
          "MEDGEN:1675899",
          "Orphanet:178396",
          "UMLS:C5190706",
          "icd11.foundation:59972355"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015801"
    },
    {
      "id": 18055,
      "label": "multiple sclerosis-ichthyosis-factor VIII deficiency syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        4360,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018787",
          "MEDGEN:1391655",
          "Orphanet:3151",
          "UMLS:C4518551"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome is characterized by the association of multiple sclerosis with lamellar ichthyosis and hematological anomalies (beta thalassemia minor and a quantitative deficit of factor VIII-von Willebrand complex). Other clinical manifestations may include eye involvement (optic atrophy, diplopia), neuromuscular involvement (ataxia, pyramidal syndrome, gait disturbance) and sensory disorder. There have been no further descriptions in the literature since 1992."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017837"
    },
    {
      "id": 18223,
      "label": "congenital fibrinogen deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002320",
          "MEDGEN:9230",
          "Orphanet:335",
          "UMLS:C0019250",
          "icd11.foundation:1452989457"
        ],
        "synonyms": [
          "congenital fibrinogen deficiency",
          "fibrinogen deficiency, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital deficiencies of fibrinogen are coagulation disorders characterized by bleeding symptoms ranging from mild to severe resulting from reduced quantity and/or quality of circulating fibrinogen. Afibrinogenemia (complete absence of fibrinogen) and hypofibrinogenemia (reduced plasma fibrinogen concentration) correspond to quantitative anomalies of fibrinogen while dysfibrinogenemia corresponds to a functional anomaly of fibrinogen. Hypo- and dysfibrinogenemia may be frequently combined (hypodysfibrinogenemia)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018060"
    },
    {
      "id": 18319,
      "label": "combined deficiency of factor V and factor VIII",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359,
        4360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016639",
          "MEDGEN:384006",
          "NANDO:2200686",
          "Orphanet:35909",
          "SCTID:715559004",
          "UMLS:C1856883",
          "icd11.foundation:184219764"
        ],
        "synonyms": [
          "F5F8D",
          "FV and FVIII combined deficiency",
          "combined deficiency of factor V and factor type VIII",
          "familial multiple coagulation factor deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Combined deficiency of factor V and factor VIII is an inherited bleeding disorder due to the reduction in activity and antigen levels of both factor V (FV) and factor VIII (FVIII) and characterized by mild-to-moderate bleeding symptoms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018175"
    },
    {
      "id": 18652,
      "label": "hemophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061030",
          "GARD:0010418",
          "MEDGEN:146334",
          "MedDRA:10061992",
          "NCIT:C3093",
          "Orphanet:448",
          "SCTID:90935002",
          "UMLS:C0684275"
        ],
        "synonyms": [
          "hemophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemophilia is a genetic disorder characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII or IX deficiency."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018660"
    },
    {
      "id": 20023,
      "label": "factor V deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025179",
          "MEDGEN:1369551",
          "MESH:D005166",
          "NANDO:2200674",
          "NCIT:C131738",
          "SCTID:4320005",
          "UMLS:C4317320"
        ],
        "synonyms": [
          "factor V deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A coagulation disorder characterized by the partial or complete absence of factor V activity in the blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020586"
    },
    {
      "id": 20034,
      "label": "acquired coagulation factor deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025183",
          "ICD10CM:D68.4",
          "MEDGEN:98",
          "NANDO:1200896",
          "NCIT:C34347",
          "SCTID:25904003",
          "UMLS:C0001169"
        ],
        "synonyms": [
          "acquired coagulation factor deficiency",
          "acquired coagulation protein disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Deficiency of a coagulation factor that is not caused by genetic alterations. Causes include vitamin K deficiency, amyloidosis, and severe liver disease."
      },
      "child_count": 6,
      "reference_id": "MONDO:0020599"
    },
    {
      "id": 21519,
      "label": "von Willebrand disease (hereditary or acquired)",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025434",
          "ICD10CM:D68.0",
          "ICD9:286.4",
          "MEDGEN:22686",
          "MESH:D014842",
          "NANDO:2200682",
          "NCIT:C68677",
          "SCTID:128105004",
          "UMLS:C0042974"
        ],
        "synonyms": [
          "VWD",
          "Von Willebrand Disease",
          "von Willebrand disorder",
          "von Willebrand's disease",
          "von Willebrand disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hereditary or acquired coagulation disorder characterized by a qualitative or quantitative deficiency of the von Willebrand factor. The latter plays an important role in platelet adhesion. Signs and symptoms include bruises, nose bleeding, gum bleeding following a dental procedure, heavy menstrual bleeding, and gastrointestinal bleeding."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024574"
    },
    {
      "id": 22902,
      "label": "factor V short isoforms-related bleeding disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022413",
          "MEDGEN:1843125",
          "Orphanet:599519",
          "UMLS:C5680279"
        ],
        "synonyms": [
          "FV short isoforms-related bleeding disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035742"
    },
    {
      "id": 22903,
      "label": "factor V amsterdam bleeding disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022414",
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          "Orphanet:599579",
          "UMLS:C5681605"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035743"
    },
    {
      "id": 22904,
      "label": "factor V atlanta bleeding disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022415",
          "MEDGEN:1842929",
          "Orphanet:600194",
          "UMLS:C5681543"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035759"
    },
    {
      "id": 22908,
      "label": "combined deficiency of factor VII and factor X",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022418",
          "MEDGEN:1843297",
          "Orphanet:600691",
          "UMLS:C5681529"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035776"
    },
    {
      "id": 24262,
      "label": "plasminogen deficiency, type II",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026269",
          "MEDGEN:904685",
          "UMLS:C4225445"
        ],
        "synonyms": [
          "plasminogen deficiency, type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100537"
    },
    {
      "id": 24263,
      "label": "dysplasminogenemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4359,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026270"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100538"
    }
  ],
  "roots": [
    {
      "id": 3738,
      "label": "blood coagulation disease"
    }
  ]
}