{
  "id": 4386,
  "label": "colon adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002271",
  "properties": {
    "xrefs": [
      "DOID:234",
      "EFO:1001949",
      "MEDGEN:137834",
      "NCIT:C4349",
      "ONCOTREE:COAD",
      "UMLS:C0338106",
      "icd11.foundation:773139368"
    ],
    "synonyms": [
      "adenocarcinoma - colon",
      "adenocarcinoma of colon",
      "adenocarcinoma of the colon",
      "colon adenocarcinoma",
      "colonic adenocarcinoma",
      "COAD"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the colon"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4179,
      "label": "colon carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20304,
        21360,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1520",
          "EFO:1001950",
          "MEDGEN:147065",
          "NCIT:C4910",
          "SCTID:269533000",
          "UMLS:C0699790",
          "icd11.foundation:865099988"
        ],
        "synonyms": [
          "colon cancer",
          "carcinoma of colon",
          "carcinoma of the colon",
          "colon carcinoma",
          "colonic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the colon"
      },
      "child_count": 18,
      "reference_id": "MONDO:0002032"
    },
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        21360
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050861",
          "DOID:0050913",
          "EFO:0000365",
          "MEDGEN:230816",
          "NCIT:C5105",
          "ONCOTREE:COADREAD",
          "SCTID:408645001",
          "UMLS:C1319315"
        ],
        "synonyms": [
          "adenocarcinoma of large bowel",
          "adenocarcinoma of large intestine",
          "adenocarcinoma of the large bowel",
          "adenocarcinoma of the large intestine",
          "colorectal (colon or rectal) adenocarcinoma",
          "colorectal adenocarcinoma",
          "colorectum adenocarcinoma",
          "large bowel adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005008"
    }
  ],
  "children": [
    {
      "id": 3172,
      "label": "colon medullary carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4386,
        20193
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080183",
          "MEDGEN:363630",
          "NCIT:C60641",
          "ONCOTREE:CMC",
          "UMLS:C1880119"
        ],
        "synonyms": [
          "colon medullary carcinoma",
          "medullary carcinoma of the colon",
          "medullary colon carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare, invasive colon adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000892"
    },
    {
      "id": 4574,
      "label": "colon signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4386,
        23338
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3033",
          "MEDGEN:313039",
          "NCIT:C7967",
          "UMLS:C1707436"
        ],
        "synonyms": [
          "colon signet Ring cell adenocarcinoma",
          "colonic signet Ring cell adenocarcinoma",
          "signet Ring cell adenocarcinoma of colon",
          "signet Ring cell adenocarcinoma of the colon",
          "signet Ring cell colon adenocarcinoma",
          "colon signet ring adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the colon characterized by the presence of malignant glandular epithelial cells which contain prominent intracytoplasmic mucin (signet ring cells). The signet ring cells constitute more than 50% of the malignant cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002495"
    },
    {
      "id": 4575,
      "label": "submucosal invasive colon adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4386,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3038",
          "MEDGEN:271523",
          "NCIT:C38760",
          "UMLS:C1515024"
        ],
        "synonyms": [
          "submucosal invasive colon adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma of the colon that has invaded into the submucosa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002496"
    },
    {
      "id": 6745,
      "label": "colon mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4386,
        6700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3029",
          "EFO:0000364",
          "MEDGEN:76007",
          "NCIT:C7966",
          "UMLS:C0279639"
        ],
        "synonyms": [
          "colloid adenocarcinoma of colon",
          "colloid adenocarcinoma of the colon",
          "colloid colon adenocarcinoma",
          "colloidal adenocarcinoma of colon",
          "colloidal adenocarcinoma of the colon",
          "colloidal colon adenocarcinoma",
          "colon colloid adenocarcinoma",
          "colon colloidal adenocarcinoma",
          "colon mucinous adenocarcinoma",
          "colonic colloid adenocarcinoma",
          "colonic colloidal adenocarcinoma",
          "colonic mucinous adenocarcinoma",
          "mucinous adenocarcinoma of colon",
          "mucinous adenocarcinoma of the colon",
          "mucinous colon adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive adenocarcinoma of the colon characterized by the presence of pools of extracellular mucin. Malignant glandular epithelial cells are present in the mucin collections. Mucin constitutes more than 50% of the lesion."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005007"
    },
    {
      "id": 7614,
      "label": "cecum adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4386,
        7615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3039",
          "EFO:1000020",
          "MEDGEN:234098",
          "NCIT:C5543",
          "SCTID:413446001",
          "UMLS:C1332866"
        ],
        "synonyms": [
          "adenocarcinoma of cecum",
          "adenocarcinoma of the cecum",
          "caecum adenocarcinoma",
          "cecal adenocarcinoma",
          "cecum adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the caecum"
      },
      "child_count": 2,
      "reference_id": "MONDO:0006028"
    }
  ],
  "roots": [
    {
      "id": 4179,
      "label": "colon carcinoma"
    },
    {
      "id": 6746,
      "label": "colorectal adenocarcinoma"
    }
  ]
}