{
  "id": 4395,
  "label": "macrocytic anemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002281",
  "properties": {
    "xrefs": [
      "DOID:2361",
      "HP:0001972",
      "MEDGEN:1920",
      "MESH:D000748",
      "NCIT:C34381",
      "SCTID:83414005",
      "UMLS:C0002886"
    ],
    "synonyms": [
      "D22S676",
      "D22S750",
      "anaemia macrocytic",
      "anemia macrocytic",
      "macrocytic Anemia",
      "macrocytic anaemia (disease)",
      "macrocytic anaemia of unspecified cause",
      "macrocytic anemia",
      "macrocytic anemia (disease)",
      "macrocytic anemia of unspecified cause"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Anemia that is characterized by increased red blood cell volume."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4394,
      "label": "anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2355",
          "HP:0001903",
          "ICD9:285.8",
          "ICD9:285.9",
          "MEDGEN:1526",
          "MESH:D000740",
          "NCIT:C2869",
          "SCTID:271737000",
          "UMLS:C0002871"
        ],
        "synonyms": [
          "anaemia (disease)",
          "anemia",
          "anemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002280"
    }
  ],
  "children": [
    {
      "id": 3888,
      "label": "megaloblastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4395
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13382",
          "HP:0001889",
          "ICD9:281.3",
          "MEDGEN:1527",
          "NANDO:2100176",
          "NANDO:2200612",
          "NCIT:C34382",
          "SCTID:53165003",
          "UMLS:C0002888"
        ],
        "synonyms": [
          "megaloblastic anaemia (disease)",
          "megaloblastic anemia",
          "megaloblastic anemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin B12 or folic acid deficiency. Other causes include toxins and drugs."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001700"
    },
    {
      "id": 9258,
      "label": "myelodysplastic syndrome associated with isolated del(5q)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4395,
        5714,
        17323,
        18812
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0090016",
          "GARD:0008723",
          "ICD10CM:D46.C",
          "ICDO:9986/3",
          "MEDGEN:226950",
          "MESH:C535323",
          "NCIT:C6867",
          "OMIM:153550",
          "Orphanet:86841",
          "SCTID:277597005",
          "UMLS:C1292779",
          "icd11.foundation:420472577"
        ],
        "synonyms": [
          "5Q minus syndrome",
          "5Q- syndrome",
          "5q- syndrome",
          "5q- syndrome, refractory macrocytic anaemia due to 5q deletion",
          "chromosome 5q deletion syndrome",
          "macrocytic anemia, refractory, due to 5q deletion, somatic",
          "myelodysplastic syndrome associated with isolated del (5q) chromosome Abnormality",
          "myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality",
          "myelodysplastic syndrome with 5q deletion",
          "myelodysplastic syndrome with isolated del(5q)",
          "5q deletion syndrome",
          "5q syndrome",
          "MAR",
          "macrocytic Anemia, refractory, due to 5Q deletion",
          "megakaryocytes, unilobular nucleated",
          "refractory macrocytic anaemia due to 5q deletion",
          "refractory macrocytic anemia due to 5q deletion"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5. The number of blasts in the bone marrow and blood is <5%. The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes. The peripheral blood shows macrocytic anemia. This syndrome occurs predominantly but not exclusively in middle age to older women. The prognosis is good and transformation to acute leukemia is rare. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0007925"
    }
  ],
  "roots": [
    {
      "id": 4394,
      "label": "anemia"
    }
  ]
}