{
  "id": 4409,
  "label": "dermis tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002300",
  "properties": {
    "xrefs": [
      "DOID:2438",
      "GARD:0023112",
      "MEDGEN:91075",
      "NCIT:C4475",
      "UMLS:C0346041"
    ],
    "synonyms": [
      "dermal neoplasm",
      "dermal tumor",
      "dermal tumour",
      "dermis neoplasm",
      "dermis neoplasm (disease)",
      "dermis tumor",
      "neoplasm of dermis",
      "neoplasm of the dermis",
      "tumor of dermis",
      "tumor of the dermis",
      "tumour of the dermis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A benign, intermediate, or malignant neoplasm that arises from the dermis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4599,
      "label": "skin neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3165",
          "EFO:0004198",
          "ICD9:239.2",
          "MEDGEN:19993",
          "MESH:D012878",
          "NCIT:C3372",
          "ONCOTREE:SKIN",
          "SCTID:126488004",
          "UMLS:C0037286"
        ],
        "synonyms": [
          "neoplasm of skin",
          "neoplasm of the skin",
          "neoplasm of zone of skin",
          "skin neoplasm",
          "skin neoplasms",
          "skin tumor",
          "skin tumour",
          "tumor of skin",
          "tumor of the skin",
          "tumor of zone of skin",
          "tumour of skin",
          "tumour of the skin",
          "tumour of zone of skin",
          "zone of skin neoplasm",
          "zone of skin neoplasm (disease)",
          "zone of skin tumor",
          "zone of skin tumour",
          "skin",
          "skin benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma."
      },
      "child_count": 34,
      "reference_id": "MONDO:0002531"
    },
    {
      "id": 20387,
      "label": "dermis disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843083",
          "Orphanet:79381",
          "UMLS:C5681483"
        ],
        "synonyms": [
          "dermis disease",
          "dermis disease or disorder",
          "disease of dermis",
          "disease or disorder of dermis",
          "disorder of dermis",
          "other dermis disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease that involves the dermis."
      },
      "child_count": 28,
      "reference_id": "MONDO:0021154"
    }
  ],
  "children": [
    {
      "id": 4403,
      "label": "cutaneous granular cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        7788
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2410",
          "GARD:0023107",
          "ICD9:215.9",
          "MEDGEN:138035",
          "NCIT:C5617",
          "SCTID:254763007",
          "UMLS:C0346060"
        ],
        "synonyms": [
          "cutaneous granular cell neoplasm",
          "cutaneous granular cell tumor",
          "granular cell neoplasm of skin",
          "granular cell neoplasm of the skin",
          "granular cell skin tumor",
          "granular cell skin tumour",
          "granular cell tumor of skin",
          "granular cell tumor of the skin",
          "granular cell tumor of zone of skin",
          "granular cell tumour of the skin",
          "granular cell tumour of zone of skin",
          "skin granular cell neoplasm",
          "zone of skin granular cell tumor",
          "zone of skin granular cell tumour",
          "skin granular cell tumor",
          "skin granular cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A granular cell tumor that involves the zone of skin."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002291"
    },
    {
      "id": 4405,
      "label": "skin glomus tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        18422
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2430",
          "GARD:0023109",
          "MEDGEN:87537",
          "NCIT:C4491",
          "SCTID:254795008",
          "UMLS:C0346083"
        ],
        "synonyms": [
          "glomus neoplasm of skin",
          "glomus neoplasm of the skin",
          "glomus skin neoplasm",
          "glomus skin tumor",
          "glomus skin tumour",
          "glomus tumor of skin",
          "glomus tumor of the skin",
          "glomus tumour of the skin",
          "skin glomus neoplasm",
          "zone of skin glomus tumor",
          "zone of skin glomus tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A glomus tumor arising from the skin. It usually presents as a small red-blue nodule and it often associated with pain at the site."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002295"
    },
    {
      "id": 5232,
      "label": "leiomyoma cutis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3776,
        4409,
        20564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5132",
          "GARD:0023435",
          "MEDGEN:87533",
          "NCIT:C4482",
          "SCTID:254767008",
          "UMLS:C0346064"
        ],
        "synonyms": [
          "cutaneous (skin) leiomyoma",
          "cutaneous leiomyoma",
          "leiomyoma cutis",
          "leiomyoma of skin",
          "leiomyoma of the skin",
          "leiomyoma of zone of skin",
          "skin leiomyoma",
          "zone of skin leiomyoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A benign smooth muscle neoplasm arising from the arrector pili muscle, tunica media of blood vessels, and dartos muscle of the genitalia. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003291"
    },
    {
      "id": 5298,
      "label": "malignant dermis tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        4907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5274",
          "GARD:0023477",
          "MEDGEN:87564",
          "NCIT:C4574",
          "SCTID:255096006",
          "UMLS:C0346811"
        ],
        "synonyms": [
          "cancer of dermis",
          "dermis cancer",
          "malignant dermal neoplasm",
          "malignant dermis neoplasm",
          "malignant dermis tumor",
          "malignant neoplasm of dermis",
          "malignant neoplasm of the dermis",
          "malignant tumor of dermis",
          "malignant tumor of the dermis",
          "malignant tumour of the dermis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the dermis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003363"
    },
    {
      "id": 8178,
      "label": "cutaneous fibrous histiocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4409,
        4989
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4418",
          "EFO:1000885",
          "GARD:0024461",
          "ICDO:8832/0",
          "MEDGEN:1930",
          "NCIT:C6801",
          "ONCOTREE:DF",
          "SCTID:448015002",
          "UMLS:C0002991"
        ],
        "synonyms": [
          "benign cutaneous fibrous histiocytoma",
          "benign fibrous cutaneous histiocytoma",
          "benign fibrous histiocytoma of skin",
          "benign fibrous histiocytoma of the skin",
          "benign skin fibrous histiocytoma",
          "cutaneous fibrous histiocytoma",
          "dermatofibroma",
          "dermatofibroma, no ICD-O subtype",
          "dermatofibroma, no ICD-O subtype (morphologic abnormality)",
          "fibrohistiocytic neoplasm",
          "fibrous histiocytoma of skin",
          "fibrous histiocytoma of the skin",
          "sclerosing angioma (morphologic abnormality)",
          "DF",
          "fibrohistiocytic tumor",
          "fibrohistiocytic tumour",
          "pleomorphic fibroma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006717"
    },
    {
      "id": 16703,
      "label": "juvenile hyaline fibromatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4409,
        7941,
        10472,
        18958,
        21247,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016583",
          "ICD9:733.29",
          "MEDGEN:411197",
          "NCIT:C98297",
          "Orphanet:2028",
          "SCTID:238861002",
          "UMLS:C2745948",
          "icd11.foundation:1890146024"
        ],
        "synonyms": [
          "Molluscum fibrosum",
          "Murray-Puretic-Drescher syndrome",
          "Puretic syndrome",
          "mesenchymal dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Juvenile hyaline fibromatosis (JHF) is a rare soft tissue tumor, characterized by papulo-nodular skin lesions (especially around the head and neck), soft tissue masses, gingival hypertrophy, joint contractures, and osteolytic bone lesions in variable degrees. Joint contractures may cripple patients and delay normal motor development if occurring in infancy. Severe gingival hyperplasia can interfere with eating and delay dentition. Histopathology analysis of involved tissues reveals cords of spindle-shaped cells embedded in an amorphous, hyaline material. JHF is a mild form of infantile systemic hyalinosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016071"
    },
    {
      "id": 18936,
      "label": "cutaneous mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        7148,
        9280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3663",
          "EFO:1000886",
          "GARD:0007842",
          "HP:0200151",
          "ICD10CM:D47.01",
          "ICDO:9740/1",
          "MEDGEN:210143",
          "MESH:D034701",
          "NCIT:C7137",
          "OMIM:154800",
          "ONCOTREE:CMCD",
          "Orphanet:66646",
          "SCTID:397012002",
          "UMLS:C1136033",
          "icd11.foundation:1300710062"
        ],
        "synonyms": [
          "CM",
          "cutaneous (skin) mastocytosis",
          "cutaneous mastocytosis",
          "cutaneous mastocytosis (disease)",
          "mastocytosis, cutaneous",
          "mastocytosis, systemic, somatic",
          "CMCD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cutaneous mastocytosis is a term referring to a group of diseases characterized by abnormal accumulation and proliferation of skin mastocytes. In some cases (most commonly in adults), cutaneous mastocytosis may occur in association with mast cell infiltration of various extracutaneous organs, in which case the disorder is referred to as systemic mastocytosis."
      },
      "child_count": 9,
      "reference_id": "MONDO:0019023"
    },
    {
      "id": 19544,
      "label": "angioma serpiginosum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        5091,
        16809,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4028",
          "GARD:0015021",
          "MEDGEN:75528",
          "NCIT:C3926",
          "Orphanet:95429",
          "SCTID:49465005",
          "UMLS:C0263637",
          "icd11.foundation:1724787481"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Angioma serpiginosum (AS) is a benign congenital skin disease characterized by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019803"
    }
  ],
  "roots": [
    {
      "id": 4599,
      "label": "skin neoplasm"
    },
    {
      "id": 20387,
      "label": "dermis disorder"
    }
  ]
}