{
  "id": 4412,
  "label": "protein S deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002304",
  "properties": {
    "xrefs": [
      "DOID:2451",
      "HGNC:9456",
      "ICD9:289.81",
      "MEDGEN:69229",
      "MESH:D018455",
      "NANDO:1201081",
      "NANDO:2100198",
      "NANDO:2200690",
      "NCIT:C99026",
      "SCTID:1563006",
      "UMLS:C0242666"
    ],
    "synonyms": [
      "Protein S deficiency",
      "Protein S deficiency disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding. Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulatednormally and affected individuals have an increased risk of forming a blood clot called a thrombosis. People at risk to haveprotein S deficiency are those with an individual or family history of multiple blood clots in the veins. Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4413,
      "label": "thrombophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2452",
          "EFO:0009315",
          "GARD:0023114",
          "ICD9:286.9",
          "MEDGEN:98306",
          "MESH:D019851",
          "NCIT:C84479",
          "Orphanet:64738",
          "SCTID:234467004",
          "UMLS:C0398623",
          "icd11.foundation:1733531851"
        ],
        "synonyms": [
          "excessive blood clotting",
          "hypercoagulability",
          "hypercoagulability state",
          "hypercoagulable"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002305"
    }
  ],
  "children": [
    {
      "id": 19022,
      "label": "hereditary thrombophilia due to congenital protein S deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4412,
        23980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111905",
          "GARD:0016543",
          "MEDGEN:748876",
          "Orphanet:743",
          "UMLS:C2584611",
          "icd11.foundation:1305244529"
        ],
        "synonyms": [
          "autosomal recessive thrombophilia due to congenital protein S deficiency",
          "hereditary thrombophilia due to congenital protein S deficiency",
          "severe hereditary thrombophilia due to congenital protein S deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Congenital protein S deficiency is an inherited coagulation disorder characterized by recurrent venous thrombosis symptoms due to reduced synthesis and/or activity levels of protein S."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019144"
    }
  ],
  "roots": [
    {
      "id": 4413,
      "label": "thrombophilia"
    }
  ]
}