{
  "id": 4413,
  "label": "thrombophilia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002305",
  "properties": {
    "xrefs": [
      "DOID:2452",
      "EFO:0009315",
      "GARD:0023114",
      "ICD9:286.9",
      "MEDGEN:98306",
      "MESH:D019851",
      "NCIT:C84479",
      "Orphanet:64738",
      "SCTID:234467004",
      "UMLS:C0398623",
      "icd11.foundation:1733531851"
    ],
    "synonyms": [
      "excessive blood clotting",
      "hypercoagulability",
      "hypercoagulability state",
      "hypercoagulable"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 3738,
      "label": "blood coagulation disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1247",
          "EFO:0009314",
          "ICD9:286",
          "ICD9:286.9",
          "ICD9:287.8",
          "MEDGEN:604",
          "MESH:D001778",
          "NCIT:C2902",
          "SCTID:64779008",
          "UMLS:C0005779"
        ],
        "synonyms": [
          "blood coagulation disorder",
          "coagulation defect",
          "coagulation disorder",
          "coagulation disorder, blood",
          "coagulation disorders, blood",
          "coagulopathy",
          "disorder, blood coagulation",
          "disorders, blood coagulation"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001531"
    }
  ],
  "children": [
    {
      "id": 3483,
      "label": "disseminated intravascular coagulation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4413
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11247",
          "GARD:0022908",
          "ICD10CM:D65",
          "ICD9:286.6",
          "MEDGEN:41620",
          "MESH:D004211",
          "NANDO:2200639",
          "NCIT:C2992",
          "SCTID:67406007",
          "UMLS:C0012739",
          "icd11.foundation:1622289887"
        ],
        "synonyms": [
          "DIC",
          "DIC, disseminated intravascular coagulation",
          "coagulation (DIC), disseminated intravascular",
          "consumptive coagulopathy",
          "defibrination syndrome",
          "diffuse or disseminated intravascular coagulation",
          "disseminated intravascular coagulation",
          "disseminated intravascular coagulation (DIC)",
          "intravascular coagulation (DIC), disseminated"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001243"
    },
    {
      "id": 4412,
      "label": "protein S deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4413
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2451",
          "HGNC:9456",
          "ICD9:289.81",
          "MEDGEN:69229",
          "MESH:D018455",
          "NANDO:1201081",
          "NANDO:2100198",
          "NANDO:2200690",
          "NCIT:C99026",
          "SCTID:1563006",
          "UMLS:C0242666"
        ],
        "synonyms": [
          "Protein S deficiency",
          "Protein S deficiency disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Protein S deficiency is a disorder that causes abnormal blood clotting. When someone bleeds, the blood begins a complicated series of rapid chemical reactions involving proteins called blood coagulation factors to stop the bleeding. Other proteins in the blood, such as protein S, usually regulate these chemical reactions to prevent excessive clotting. When protein S is missing (deficient), clotting may not be regulatednormally and affected individuals have an increased risk of forming a blood clot called a thrombosis. People at risk to haveprotein S deficiency are those with an individual or family history of multiple blood clots in the veins. Treatment may include taking medication known as blood thinners to decrease the chance of developing a blood clot."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002304"
    },
    {
      "id": 18824,
      "label": "thrombotic thrombocytopenic purpura",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4413,
        23244
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10772",
          "GARD:0016659",
          "MEDGEN:48266",
          "MESH:D011697",
          "MedDRA:10043648",
          "NANDO:1200316",
          "NANDO:2100189",
          "NANDO:2200649",
          "NCIT:C78797",
          "NORD:1769",
          "Orphanet:54057",
          "SCTID:78129009",
          "UMLS:C0034155",
          "icd11.foundation:1708277768"
        ],
        "synonyms": [
          "Moschcowitz disease",
          "Moschowitz disease",
          "TTP"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018896"
    },
    {
      "id": 23980,
      "label": "inherited thrombophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4413,
        20411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026094",
          "MEDGEN:391721",
          "OMIMPS:188050",
          "UMLS:C2584620"
        ],
        "synonyms": [
          "hereditary hypercoagulable disorder",
          "hereditary thrombophilia",
          "thrombophilia, hereditary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of thrombophilia that is inherited."
      },
      "child_count": 24,
      "reference_id": "MONDO:0100240"
    }
  ],
  "roots": [
    {
      "id": 3738,
      "label": "blood coagulation disease"
    }
  ]
}