{ "id": 4457, "label": "laryngeal carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0002358", "properties": { "xrefs": [ "DOID:2600", "GARD:0006862", "MEDGEN:108889", "NCIT:C4855", "SCTID:276975007", "UMLS:C0595989" ], "synonyms": [ "cancer of larynx", "cancer of the larynx", "laryngeal cancer", "laryngeal throat cancer", "carcinoma of larynx", "carcinoma of the larynx", "laryngeal carcinoma", "larynx carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation." }, "isLeaf": false, "isRoot": false, "child_count": 8, "parents": [ { "id": 4451, "label": "larynx cancer", "isLeaf": false, "isRoot": false, "parents": [ 2875, 20312 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2596", "EFO:1000354", "GARD:0027604", "ICD10CM:C32", "ICD9:161", "ICD9:161.8", "ICD9:161.9", "MEDGEN:2868", "NCIT:C7484", "SCTID:363429002", "UMLS:C0007107", "icd11.foundation:75194057" ], "synonyms": [ "cancer of larynx", "larynx cancer", "malignant laryngeal neoplasm", "malignant laryngeal tumor", "malignant laryngeal tumour", "malignant larynx neoplasm", "malignant larynx tumor", "malignant larynx tumour", "malignant neoplasm of larynx", "malignant neoplasm of the larynx", "malignant tumor of larynx", "malignant tumor of the larynx", "malignant tumour of larynx", "malignant tumour of the larynx" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas." }, "child_count": 14, "reference_id": "MONDO:0002352" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" } ], "children": [ { "id": 4454, "label": "glottis carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4450, 4457 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2599", "GARD:0027605", "MEDGEN:152820", "NCIT:C4923", "SCTID:372103002", "UMLS:C0740083" ], "synonyms": [ "cancer of glottis", "cancer of the glottis", "glottic throat cancer", "glottis cancer", "carcinoma of glottis", "carcinoma of the glottis", "glottic carcinoma", "glottis carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the glottis." }, "child_count": 4, "reference_id": "MONDO:0002355" }, { "id": 5080, "label": "laryngeal mucoepidermoid carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4457, 5029 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4688", "GARD:0023367", "MEDGEN:272792", "NCIT:C9463", "UMLS:C1334373" ], "synonyms": [ "laryngeal mucoepidermoid carcinoma", "laryngeal throat mucoepidermoid cancer", "larynx mucoepidermoid carcinoma", "mucoepidermoid carcinoma of larynx", "mucoepidermoid carcinoma of the larynx" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A rare mucoepidermoid carcinoma of the larynx. It usually arises from the supraglottic area. Hoarseness and dysphagia are the presenting symptoms." }, "child_count": 0, "reference_id": "MONDO:0003095" }, { "id": 6171, "label": "carcinoma of supraglottis", "isLeaf": false, "isRoot": false, "parents": [ 3912, 4457 ], "type_id": 0, "properties": { "xrefs": [ "DOID:7763", "GARD:0009478", "MEDGEN:266243", "NCIT:C5973", "SCTID:372105009", "UMLS:C1299240" ], "synonyms": [ "cancer of supraglottis", "cancer of the supraglottis", "carcinoma of supraglottic part of larynx", "carcinoma of supraglottis", "carcinoma of the supraglottis", "supraglottic cancer", "supraglottic carcinoma", "supraglottic part of larynx carcinoma", "supraglottic throat cancer", "supraglottis carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A carcinoma of the larynx that arises from the supraglottic area." }, "child_count": 4, "reference_id": "MONDO:0004357" }, { "id": 6172, "label": "subglottis carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3526, 4457 ], "type_id": 0, "properties": { "xrefs": [ "DOID:7764", "GARD:0027678", "MEDGEN:226968", "NCIT:C5972", "SCTID:372104008", "UMLS:C1299239" ], "synonyms": [ "cancer of subglottis", "cancer of the subglottis", "subglottic cancer", "subglottic throat cancer", "carcinoma of subglottis", "carcinoma of the subglottis", "subglottic carcinoma", "subglottis carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A carcinoma of the larynx that arises from the subglottic area." }, "child_count": 2, "reference_id": "MONDO:0004358" }, { "id": 6476, "label": "larynx carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 4457, 6433 ], "type_id": 0, "properties": { "xrefs": [ "DOID:9011", "GARD:0027702", "ICD10CM:D02.0", "ICD9:231.0", "MEDGEN:56336", "NCIT:C9100", "SCTID:92634009", "UMLS:C0154069" ], "synonyms": [ "carcinoma in situ of larynx", "carcinoma in situ of the larynx", "laryngeal cancer stage 0", "laryngeal carcinoma in situ", "laryngeal carcinoma stage 0", "larynx carcinoma in situ", "larynx in situ carcinoma", "stage 0 carcinoma of larynx", "stage 0 carcinoma of the larynx", "stage 0 laryngeal cancer", "stage 0 laryngeal cancer aJCC v6", "stage 0 laryngeal cancer aJCC v6, v7, and V8", "stage 0 laryngeal cancer aJCC v7", "stage 0 laryngeal cancer aJCC v8", "stage 0 laryngeal carcinoma", "stage 0 laryngeal carcinoma in situ", "stage 0 laryngeal throat cancer", "stage 0 larynx carcinoma" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A in situ carcinoma that involves the larynx." }, "child_count": 2, "reference_id": "MONDO:0004696" }, { "id": 7239, "label": "laryngeal squamous cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4457, 11332 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2876", "EFO:0006352", "GARD:0017908", "MEDGEN:83630", "NCIT:C4044", "ONCOTREE:LXSC", "Orphanet:494550", "SCTID:405822008", "UMLS:C0280324" ], "synonyms": [ "epidermoid carcinoma of larynx", "epidermoid carcinoma of the larynx", "laryngeal epidermoid carcinoma", "laryngeal squamous cell carcinoma", "laryngeal throat squamous cell cancer", "larynx epidermoid carcinoma", "larynx squamous cell carcinoma", "squamous cell carcinoma of larynx", "squamous cell carcinoma of the larynx", "LXSC" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx." }, "child_count": 8, "reference_id": "MONDO:0005595" }, { "id": 7808, "label": "laryngeal adenoid cystic carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4457, 6713 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4869", "EFO:1000319", "GARD:0024351", "MEDGEN:232690", "NCIT:C9462", "UMLS:C1334368" ], "synonyms": [ "adenoid cystic carcinoma of larynx", "adenoid cystic carcinoma of the larynx", "laryngeal adenoid cystic carcinoma", "laryngeal throat adenoid cystic cancer" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" } ], "definition": "A rare adenoid cystic carcinoma of the larynx. It usually arises from the supraglottic or subglottic area. It is characterized by slow progression and late distant metastases." }, "child_count": 0, "reference_id": "MONDO:0006264" }, { "id": 7809, "label": "laryngeal small cell carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2894, 4185, 4457, 16044 ], "type_id": 0, "properties": { "xrefs": [ "DOID:7144", "EFO:1000320", "GARD:0024352", "MEDGEN:233611", "NCIT:C6025", "UMLS:C1334378" ], "synonyms": [ "laryngeal small cell carcinoma", "laryngeal throat small cell cancer", "larynx small cell carcinoma", "small cell carcinoma of larynx", "small cell carcinoma of the larynx" ], "categories": [ { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A rare carcinoma that arises from the larynx. It is characterized by the presence of small neuroendocrine cells. It metastasizes early and has an aggressive clinical course." }, "child_count": 0, "reference_id": "MONDO:0006265" } ], "roots": [ { "id": 4451, "label": "larynx cancer" }, { "id": 6734, "label": "carcinoma" } ] }