{
  "id": 4465,
  "label": "kidney cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002367",
  "properties": {
    "xrefs": [
      "DOID:263",
      "ICD9:189.0",
      "MEDGEN:149263",
      "MESH:D007680",
      "NCIT:C7548",
      "SCTID:363518003",
      "UMLS:C0740457"
    ],
    "synonyms": [
      "cancer of kidney",
      "kidney cancer",
      "malignant kidney neoplasm",
      "malignant kidney tumor",
      "malignant kidney tumour",
      "malignant neoplasm of kidney",
      "malignant neoplasm of the kidney",
      "malignant renal neoplasm",
      "malignant renal tumor",
      "malignant renal tumour",
      "malignant tumor of kidney",
      "malignant tumor of the kidney",
      "malignant tumour of the kidney"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Primary or metastatic malignant neoplasm involving the kidney."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 7836,
      "label": "malignant urinary system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20307
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3996",
          "EFO:1000363",
          "ICD10CM:C64-C68",
          "ICD9:189.9",
          "MEDGEN:738719",
          "NCIT:C192668",
          "NCIT:C9297",
          "SCTID:448233000",
          "UMLS:C1644719"
        ],
        "synonyms": [
          "cancer of renal system",
          "malignant neoplasm of renal system",
          "malignant renal system neoplasm",
          "malignant urinary system neoplasm",
          "malignant urinary tract neoplasm",
          "renal system cancer",
          "urinary system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant tumor involving the urinary system. Common tumor types include carcinomas, lymphomas, and sarcomas."
      },
      "child_count": 20,
      "reference_id": "MONDO:0006295"
    },
    {
      "id": 20396,
      "label": "kidney neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6948,
        20307
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003865",
          "ICD9:239.5",
          "MEDGEN:5967",
          "NCIT:C3150",
          "ONCOTREE:KIDNEY",
          "SCTID:126880001",
          "UMLS:C0022665"
        ],
        "synonyms": [
          "kidney neoplasm",
          "kidney neoplasm (disease)",
          "kidney tumor",
          "kidney tumour",
          "neoplasm of kidney",
          "neoplasm of the kidney",
          "renal neoplasm",
          "renal tumor",
          "renal tumors",
          "renal tumour",
          "renal tumours",
          "tumor of kidney",
          "tumor of the kidney",
          "tumour of kidney",
          "tumour of the kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021163"
    }
  ],
  "children": [
    {
      "id": 4936,
      "label": "kidney sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4242",
          "GARD:0023305",
          "ICD9:189.0",
          "MEDGEN:87548",
          "NCIT:C4525",
          "SCTID:254918001",
          "UMLS:C0346251"
        ],
        "synonyms": [
          "kidney sarcoma",
          "renal sarcoma",
          "sarcoma of kidney",
          "sarcoma of the kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A sarcoma involving a kidney."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002930"
    },
    {
      "id": 5106,
      "label": "mesoblastic nephroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4772",
          "EFO:0007365",
          "ICD9:236.99",
          "MEDGEN:64620",
          "MESH:D018201",
          "SCTID:307604008",
          "UMLS:C0206628"
        ],
        "synonyms": [
          "mesoblastic nephroma",
          "mesoblastic nephroma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A solid, unencapsulated tumor of the kidney composed of spindle mesenchymal cells that resemble fibroblasts or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003130"
    },
    {
      "id": 6923,
      "label": "renal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4451",
          "EFO:0002890",
          "MEDGEN:235133",
          "NCIT:C9384",
          "UMLS:C1378703",
          "icd11.foundation:1075394530"
        ],
        "synonyms": [
          "kidney (including renal cell) cancer",
          "kidney (renal) cancer",
          "kidney cancer",
          "renal cancer",
          "carcinoma of kidney",
          "kidney carcinoma",
          "renal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005206"
    },
    {
      "id": 18919,
      "label": "kidney Wilms tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        7641
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2154",
          "DOID:5176",
          "GARD:0007892",
          "ICDO:8960/3",
          "MedDRA:10029145",
          "NANDO:2200043",
          "NCIT:C40407",
          "NORD:1855",
          "ONCOTREE:WT",
          "Orphanet:654",
          "SCTID:302849000"
        ],
        "synonyms": [
          "Wilms tumor",
          "Wilms tumour",
          "Wilms' tumor",
          "Wilms' tumour",
          "Wilms tumor of the kidney",
          "Wilms tumour of the kidney",
          "Wilms' Tumor",
          "Wilms' tumor of the kidney",
          "Wilms' tumour of the kidney",
          "kidney Wilms tumor",
          "nephroblastoma",
          "nephroblastoma, malignant",
          "renal Wilms tumor",
          "renal Wilms tumour",
          "renal Wilms' tumor",
          "renal embryonic tumor",
          "renal embryonic tumour",
          "adult nephroblastoma",
          "adult renal Wilms' tumour",
          "childhood renal Wilms tumor",
          "childhood renal Wilms tumour",
          "childhood renal Wilms' cancer",
          "embryonal nephroma",
          "nonanaplastic renal Wilm's tumor",
          "nonanaplastic renal Wilm's tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver."
      },
      "child_count": 16,
      "reference_id": "MONDO:0019004"
    },
    {
      "id": 21204,
      "label": "Graham-Boyle-Troxell syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4465,
        10167,
        20656
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002557",
          "ICD9:759.6",
          "MEDGEN:444062",
          "MESH:C537292",
          "Orphanet:2111",
          "SCTID:707530009",
          "UMLS:C2931468"
        ],
        "synonyms": [
          "Graham-Boyle-Troxell syndrome",
          "cystic hamartoma of lung and kidney",
          "graham Boyle Troxell syndrome",
          "cystic hamartomata of lung and kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Cystic hamartoma of lung and kidney is a rare developmental malformation reported in 3 patients characterized by the presence of benign hamartomatous cysts in kidney and lung, clinically presenting as abdominal mass. Others associated features include hyperplastic nephromegaly, medullary dysplasia and mesoblastic nephroma. There have been no further descriptions in the literature since 1987."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023275"
    },
    {
      "id": 21581,
      "label": "malignant mixed epithelial stromal tumor of the kidney",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4465,
        4482,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:233156",
          "NCIT:C37265",
          "UMLS:C1334602"
        ],
        "synonyms": [
          "malignant MEST",
          "malignant mixed epithelial stromal tumor of the kidney",
          "mixed epithelial stromal tumor of the kidney, malignant",
          "mixed epithelial stromal tumour of the kidney, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A mixed epithelial stromal tumor of the kidney with malignant stromal features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024711"
    },
    {
      "id": 22942,
      "label": "childhood malignant kidney neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        4767,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:904186",
          "NCIT:C123907",
          "UMLS:C4086162"
        ],
        "synonyms": [
          "childhood kidney cancer",
          "childhood malignant kidney neoplasm",
          "childhood malignant kidney tumor",
          "childhood malignant kidney tumour",
          "childhood malignant renal neoplasm",
          "childhood malignant renal tumor",
          "childhood malignant renal tumour",
          "kidney cancer of childhood",
          "paediatric kidney cancer",
          "pediatric kidney cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A malignant neoplasm that affects the kidney and occurs in childhood."
      },
      "child_count": 9,
      "reference_id": "MONDO:0036511"
    },
    {
      "id": 23480,
      "label": "malignant renal pelvis neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        5600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:57793",
          "NCIT:C7525",
          "UMLS:C0153618"
        ],
        "synonyms": [
          "cancer of renal pelvis",
          "malignant neoplasm of renal pelvis",
          "malignant neoplasm of the renal pelvis",
          "malignant renal pelvis neoplasm",
          "malignant renal pelvis tumor",
          "malignant renal pelvis tumour",
          "malignant tumor of renal pelvis",
          "malignant tumor of the renal pelvis",
          "malignant tumour of renal pelvis",
          "malignant tumour of the renal pelvis",
          "renal pelvis cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the renal pelvis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0044919"
    }
  ],
  "roots": [
    {
      "id": 7836,
      "label": "malignant urinary system neoplasm"
    },
    {
      "id": 20396,
      "label": "kidney neoplasm"
    }
  ]
}