{
  "id": 4491,
  "label": "malignant tenosynovial giant cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002401",
  "properties": {
    "xrefs": [
      "DOID:2704",
      "GARD:0027606",
      "ICDO:9252/3",
      "MEDGEN:226849",
      "NCIT:C6535",
      "UMLS:C1266168"
    ],
    "synonyms": [
      "giant cell tumor of tendon sheath, malignant",
      "malignant giant cell neoplasm of tendon sheath",
      "malignant giant cell neoplasm of the tendon sheath",
      "malignant giant cell tumor of tendon sheath",
      "malignant giant cell tumor of the tendon sheath",
      "malignant giant cell tumour of tendon sheath",
      "malignant giant cell tumour of the tendon sheath",
      "malignant tendon sheath giant cell neoplasm",
      "malignant tendon sheath giant cell tumor",
      "malignant tendon sheath giant cell tumour",
      "malignant tenosynovial giant cell tumor",
      "tenosynovial giant cell tumor, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "An uncommon malignant tumor arising from the tendon sheath. Morphologically, it is characterized by the presence of a cellular infiltrate reminiscent of a giant cell tumor with prominent malignant characteristics. Recurrent giant cell tumors with a sarcomatous dedifferentiation are included in this category as well."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4492,
      "label": "malignant giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4297,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2705",
          "ICDO:8003/3",
          "MEDGEN:90745",
          "NCIT:C4090",
          "UMLS:C0334229"
        ],
        "synonyms": [
          "giant cell tumor, malignant",
          "malignant giant cell neoplasm",
          "malignant giant cell tumor",
          "malignant tumor, giant cell type",
          "malignant tumor, giant cell type (morphologic abnormality)"
        ],
        "definition": "A malignant neoplasm characterized by then presence of atypical giant cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002402"
    },
    {
      "id": 4493,
      "label": "synovium cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3041,
        4597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2706",
          "GARD:0027607",
          "MEDGEN:277340",
          "NCIT:C6531",
          "UMLS:C1334624"
        ],
        "synonyms": [
          "cancer of layer of synovial tissue",
          "cancer of synovial membrane of synovial joint",
          "layer of synovial tissue cancer",
          "malignant layer of synovial tissue neoplasm",
          "malignant neoplasm of layer of synovial tissue",
          "malignant neoplasm of synovial membrane of synovial joint",
          "malignant neoplasm of synovium",
          "malignant neoplasm of the synovium",
          "malignant synovial membrane of synovial joint neoplasm",
          "malignant synovial neoplasm",
          "malignant synovial tumor",
          "malignant synovial tumour",
          "malignant tumor of synovium",
          "malignant tumor of the synovium",
          "malignant tumour of synovium",
          "malignant tumour of the synovium",
          "synovial membrane of synovial joint cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A cancer that involves the layer of synovial tissue."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002403"
    },
    {
      "id": 4592,
      "label": "tenosynovial giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4297,
        4597,
        20678,
        21600
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:314",
          "EFO:1000562",
          "ICD9:727.89",
          "ICDO:9252/0",
          "MEDGEN:232927",
          "NCIT:C3402",
          "SCTID:310605004",
          "UMLS:C1318543"
        ],
        "synonyms": [
          "fibrous histiocytoma of tendon sheath",
          "giant cell neoplasm of Tenosynovium",
          "giant cell neoplasm of tendon sheath",
          "giant cell neoplasm of the Tenosynovium",
          "giant cell tumor of Tenosynovium",
          "giant cell tumor of tendon sheath",
          "giant cell tumor of the Tenosynovium",
          "giant cell tumour of the Tenosynovium",
          "tendon sheath giant cell neoplasm",
          "tendon sheath giant cell tumor",
          "tendon sheath giant cell tumour",
          "tenosynovial giant cell neoplasm",
          "tenosynovial giant cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002522"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4492,
      "label": "malignant giant cell tumor"
    },
    {
      "id": 4493,
      "label": "synovium cancer"
    },
    {
      "id": 4592,
      "label": "tenosynovial giant cell tumor"
    }
  ]
}