{
  "id": 4492,
  "label": "malignant giant cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002402",
  "properties": {
    "xrefs": [
      "DOID:2705",
      "ICDO:8003/3",
      "MEDGEN:90745",
      "NCIT:C4090",
      "UMLS:C0334229"
    ],
    "synonyms": [
      "giant cell tumor, malignant",
      "malignant giant cell neoplasm",
      "malignant giant cell tumor",
      "malignant tumor, giant cell type",
      "malignant tumor, giant cell type (morphologic abnormality)"
    ],
    "definition": "A malignant neoplasm characterized by then presence of atypical giant cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4297,
      "label": "giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:200",
          "MEDGEN:6598",
          "MESH:D005870",
          "NCIT:C3055",
          "SCTID:443790001",
          "UMLS:C0017525"
        ],
        "synonyms": [
          "giant cell neoplasm",
          "giant cell tumor",
          "giant cell tumor (morphologic abnormality)",
          "giant cell tumor (qualifier value)",
          "giant cell tumor NOS (morphologic abnormality)",
          "giant cell tumors (morphologic abnormality)",
          "giant cell tumour (morphologic abnormality)",
          "giant cell tumour (qualifier value)",
          "giant cell tumour NOS (morphologic abnormality)",
          "giant cell tumours (morphologic abnormality)",
          "tumor of the giant cell",
          "tumour of the giant cell",
          "giant cell tumors",
          "giant cell tumours"
        ],
        "definition": "A benign, intermediate, or malignant tumor that arises from the bone or soft tissue. It is characterized by the presence of multinucleated osteoclast-like giant cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002171"
    },
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    }
  ],
  "children": [
    {
      "id": 4491,
      "label": "malignant tenosynovial giant cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4492,
        4493,
        4592
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2704",
          "GARD:0027606",
          "ICDO:9252/3",
          "MEDGEN:226849",
          "NCIT:C6535",
          "UMLS:C1266168"
        ],
        "synonyms": [
          "giant cell tumor of tendon sheath, malignant",
          "malignant giant cell neoplasm of tendon sheath",
          "malignant giant cell neoplasm of the tendon sheath",
          "malignant giant cell tumor of tendon sheath",
          "malignant giant cell tumor of the tendon sheath",
          "malignant giant cell tumour of tendon sheath",
          "malignant giant cell tumour of the tendon sheath",
          "malignant tendon sheath giant cell neoplasm",
          "malignant tendon sheath giant cell tumor",
          "malignant tendon sheath giant cell tumour",
          "malignant tenosynovial giant cell tumor",
          "tenosynovial giant cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An uncommon malignant tumor arising from the tendon sheath. Morphologically, it is characterized by the presence of a cellular infiltrate reminiscent of a giant cell tumor with prominent malignant characteristics. Recurrent giant cell tumors with a sarcomatous dedifferentiation are included in this category as well."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002401"
    },
    {
      "id": 5462,
      "label": "malignant giant cell tumor of soft parts",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4275,
        4492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5638",
          "GARD:0023564",
          "ICDO:9251/3",
          "MEDGEN:90807",
          "NCIT:C8380",
          "UMLS:C0334554"
        ],
        "synonyms": [
          "giant cell fibrous histiocytoma",
          "giant cell malignant fibrous histiocytoma",
          "malignant Osteoclastoma",
          "malignant giant cell neoplasm of soft parts",
          "malignant giant cell tumor of soft parts",
          "malignant giant cell tumor of soft parts (morphologic abnormality)",
          "malignant giant cell tumour of soft parts (morphologic abnormality)",
          "undifferentiated pleomorphic sarcoma with osteoclast-like giant cells"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like giant cells and cellular pleomorphism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003561"
    },
    {
      "id": 7785,
      "label": "giant cell tumor of soft tissue",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4492,
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000281",
          "ICDO:9251/1",
          "MEDGEN:87264",
          "NCIT:C49107",
          "UMLS:C0334553"
        ],
        "synonyms": [
          "GCT-ST",
          "Osteoclastoma of soft tissue",
          "giant cell tumor of soft tissue"
        ],
        "definition": "A painless, well circumscribed tumor arising in soft tissue, usually of the upper and lower extremities. Morphologically, it is characterized by a multinodular growth pattern. The cellular infiltrate is composed of mononuclear round or oval cells and multinucleated osteoclast-like giant cells, in a rich vascular stroma. It rarely metastasizes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006232"
    },
    {
      "id": 7830,
      "label": "malignancy in giant cell tumor of bone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4492,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4719",
          "EFO:1000347",
          "GARD:0024361",
          "ICDO:9250/3",
          "MEDGEN:87263",
          "NANDO:2200052",
          "NCIT:C4304",
          "UMLS:C0334552"
        ],
        "synonyms": [
          "Dedifferentiated giant cell tumor",
          "Dedifferentiated giant cell tumour",
          "OSTEOCLASTOMA, malignant",
          "bone giant cell sarcoma",
          "giant cell bone sarcoma",
          "giant cell sarcoma of bone",
          "giant cell sarcoma of the bone",
          "giant cell tumor of bone, malignant",
          "giant cell tumor of bone, malignant (morphologic abnormality)",
          "giant cell tumour of bone, malignant",
          "giant cell tumour of bone, malignant (morphologic abnormality)",
          "malignancy in giant cell tumor of bone",
          "malignancy in giant cell tumor of the bone",
          "malignancy in giant cell tumour of the bone",
          "malignant giant cell tumor of bone",
          "malignant giant cell tumour of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant tumor that arises from the bone. It is characterized by the presence of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing giant cell tumor may or may not be apparent (secondary malignancy in giant cell tumor)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006287"
    }
  ],
  "roots": [
    {
      "id": 4297,
      "label": "giant cell tumor"
    },
    {
      "id": 6733,
      "label": "cancer"
    }
  ]
}