{
  "id": 4530,
  "label": "endometrial carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002447",
  "properties": {
    "xrefs": [
      "DOID:2871",
      "EFO:1001512",
      "HP:0012114",
      "MEDGEN:96903",
      "NCIT:C7558",
      "ONCOTREE:UCEC",
      "SCTID:254878006",
      "UMLS:C0476089",
      "icd11.foundation:1123821211"
    ],
    "synonyms": [
      "endometrial cancer",
      "carcinoma of endometrium",
      "carcinoma of the endometrium",
      "carcinoma, endometrial, malignant",
      "endometrial carcinoma",
      "endometrial carcinoma (disease)",
      "endometrium carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6929,
      "label": "uterine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002919",
          "MEDGEN:755620",
          "SCTID:446022000",
          "UMLS:C2960452"
        ],
        "synonyms": [
          "carcinoma of uterus",
          "uterus carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma involving a uterus."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005213"
    },
    {
      "id": 13033,
      "label": "endometrial cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        20459
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1380",
          "ICD10CM:C54.1",
          "MEDGEN:2840",
          "NCIT:C27815",
          "OMIM:608089",
          "UMLS:C0007103"
        ],
        "synonyms": [
          "endometrial neoplasm",
          "neoplasm of endometrium",
          "tumor of endometrium",
          "tumour of endometrium",
          "cancer of endometrium",
          "endometrial cancer",
          "endometrial cancer, familial, autosomal dominant, somatic mutation",
          "endometrial cancer, susceptibility to, autosomal dominant, somatic mutation",
          "endometrial carcinoma, somatic",
          "endometrium cancer",
          "malignant endometrial neoplasm",
          "malignant endometrium neoplasm",
          "malignant neoplasm of endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0011962"
    }
  ],
  "children": [
    {
      "id": 2992,
      "label": "uterine corpus endometrial carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050939"
        ],
        "synonyms": [
          "body of uterus endometrial carcinoma (disease)",
          "endometrial carcinoma (disease) of body of uterus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A endometrial carcinoma (disease) that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000553"
    },
    {
      "id": 4850,
      "label": "endometrial transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4005",
          "GARD:0023259",
          "MEDGEN:273232",
          "NCIT:C40154",
          "UMLS:C1516864"
        ],
        "synonyms": [
          "endometrial transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare primary carcinoma of the endometrium characterized by the presence of malignant epithelial cells resembling urothelial transitional cells. The malignant transitional cells constitute at least 90% of the tumor cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002832"
    },
    {
      "id": 5255,
      "label": "endometrium carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        6489
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5172",
          "ICD10CM:D07.0",
          "ICD9:233.2",
          "MEDGEN:87545",
          "SCTID:92582009",
          "UMLS:C0346191"
        ],
        "synonyms": [
          "carcinoma in situ of endometrium",
          "endometrium in situ carcinoma",
          "stage 0 endometrium carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma in situ involving a endometrium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003315"
    },
    {
      "id": 7120,
      "label": "endometrium adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4530,
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2870",
          "EFO:0005232",
          "MEDGEN:218862",
          "NCIT:C7359",
          "UMLS:C1153706"
        ],
        "synonyms": [
          "endometrioid carcinoma of endometrium",
          "adenocarcinoma of endometrium",
          "adenocarcinoma of the endometrium",
          "adenocarcinoma, endometrial, malignant",
          "endometrial adenocarcinoma",
          "endometrioid adenoma or carcinoma NOS (morphologic abnormality)",
          "endometrioid adenomas and carcinomas (morphologic abnormality)",
          "endometrium adenocarcinoma",
          "endometrial endometrioid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005461"
    },
    {
      "id": 7752,
      "label": "endometrial small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        4530
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7139",
          "EFO:1000239",
          "GARD:0024324",
          "MEDGEN:309057",
          "NCIT:C40155",
          "UMLS:C1516858",
          "icd11.foundation:845680139"
        ],
        "synonyms": [
          "endometrial small cell carcinoma",
          "endometrium small cell carcinoma",
          "small cell carcinoma of endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary carcinoma of the endometrium that is similar to the small cell carcinoma of the lung, histologically."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006197"
    },
    {
      "id": 7753,
      "label": "endometrial squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4530,
        6823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5533",
          "EFO:1000240",
          "MEDGEN:234217",
          "NCIT:C8719",
          "UMLS:C1333396",
          "icd11.foundation:1130568776"
        ],
        "synonyms": [
          "endometrial squamous cell carcinoma",
          "endometrium squamous cell carcinoma",
          "squamous cell carcinoma of endometrium",
          "squamous cell carcinoma of the endometrium"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary carcinoma of the endometrium characterized by the presence of malignant squamous cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006198"
    },
    {
      "id": 7754,
      "label": "endometrial undifferentiated carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4530,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000242",
          "MEDGEN:274013",
          "NCIT:C40156",
          "UMLS:C1516865",
          "icd11.foundation:130578959"
        ],
        "synonyms": [
          "endometrial undifferentiated carcinoma",
          "undifferentiated endometrial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary carcinoma of the endometrium characterized by the presence of malignant cells that lack evidence of differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006199"
    }
  ],
  "roots": [
    {
      "id": 6929,
      "label": "uterine carcinoma"
    },
    {
      "id": 13033,
      "label": "endometrial cancer"
    }
  ]
}