{
  "id": 4539,
  "label": "type IV hypersensitivity disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002459",
  "properties": {
    "xrefs": [
      "DOID:2916",
      "MEDGEN:9371",
      "NCIT:C3115",
      "UMLS:C0020522"
    ],
    "synonyms": [
      "DTH",
      "delayed hypersensitivity reaction",
      "delayed-type hypersensitivity",
      "delayed-type hypersensitivity response",
      "disorder of type IV hypersensitivity",
      "type 4 hypersensitivity reaction",
      "type IV hypersensitivity",
      "type IV hypersensitivity reaction",
      "hypersensitivity reaction type IV disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A disease that has its basis in the disruption of type IV hypersensitivity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    }
  ],
  "children": [
    {
      "id": 7222,
      "label": "cryoglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4539,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2917",
          "EFO:0005846",
          "ICD10CM:D89.1",
          "ICD9:273.2",
          "MEDGEN:3673",
          "MESH:D003449",
          "NCIT:C26736",
          "SCTID:30911005",
          "UMLS:C0010403"
        ],
        "synonyms": [
          "cryoglobulinemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Cryoglobulinemia is a type of vasculitis that is caused by abnormal proteins (antibodies) in the blood called 'cryoglobulins.' At cold temperatures, these proteins become solid or gel-like, which can block blood vessels and cause a variety of health problems. Many people affected by this condition will not experience any unusual signs or symptoms. When present, symptoms vary but may include breathing problems; fatigue; glomerulonephritis ; joint or muscle pain; purpura ; Raynaud's phenomenon ; skin death; and/or skin ulcers. In some cases, the exact underlying cause is unknown; however, cryoglobulinemia can be associated with a variety of conditions including certain types of infection; chronic inflammatory diseases (such as autoimmune disease); and/or cancers of the blood or immune system. Treatment varies based on the severity of the condition, the symptoms present in each person and the underlying cause."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005576"
    },
    {
      "id": 18157,
      "label": "autoimmune lymphoproliferative syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4539,
        8586,
        17033,
        20301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:1560-5548",
          "DOID:6688",
          "GARD:0008686",
          "ICD10CM:D89.82",
          "MESH:D056735",
          "MedDRA:10069521",
          "NANDO:1200352",
          "NANDO:2200726",
          "NCIT:C37864",
          "Orphanet:3261",
          "icd11.foundation:1072688797"
        ],
        "synonyms": [
          "ALPS",
          "ALPS (autoimmune lymphoproliferative syndrome)",
          "Canale-Smith syndrome",
          "FAS deficiency",
          "autoimmune lymphoproliferative syndrome type 1, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0017979"
    },
    {
      "id": 23250,
      "label": "serum sickness",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4539,
        8426
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:11390",
          "MESH:D012713",
          "NCIT:C79718",
          "SCTID:72284000",
          "UMLS:C0036830",
          "icd11.foundation:715261250"
        ],
        "synonyms": [
          "serum sickness",
          "transfusion reaction due to serum protein reaction",
          "Sicknesses, serum",
          "intoxication by serum",
          "protein sickness",
          "serum Sicknesses",
          "serum reaction",
          "sickness, serum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest pain, and dyspnea. Certain drugs (e.g., antibiotics, anticancer agents, and anti-inflammatory medications) and infectious disorders (e.g., hepatitis B) may also cause serum sickness-like reaction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043789"
    }
  ],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    }
  ]
}