{
  "id": 4545,
  "label": "bronchiolitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002465",
  "properties": {
    "xrefs": [
      "DOID:2942",
      "HP:0011950",
      "ICD9:466.19",
      "MEDGEN:14235",
      "MESH:D001988",
      "NCIT:C39658",
      "SCTID:4120002",
      "UMLS:C0006271"
    ],
    "synonyms": [
      "bronchiolitis",
      "bronchiolitis (disease)",
      "wheezy bronchitis",
      "RSV bronchiolitis",
      "viral bronchiolitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Inflammation of the bronchioles characterized by swelling of the bronchioles and mucus accumulation. It is usually caused by the respiratory syncytial virus and affects children. Signs and symptoms include coughing, wheezing, and shortness of breath."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6971,
      "label": "lung disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:850",
          "EFO:0003818",
          "ICD9:518.89",
          "MEDGEN:7399",
          "MESH:D008171",
          "NCIT:C3198",
          "SCTID:19829001",
          "UMLS:C0024115"
        ],
        "synonyms": [
          "disease of lung",
          "disease or disorder of lung",
          "disorder of lung",
          "lung disease",
          "lung disease or disorder",
          "lung disorder",
          "lung disorders",
          "pulmonary disease",
          "pulmonary diseases",
          "pulmonary disorder",
          "pulmonary disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A disease involving the lung."
      },
      "child_count": 33,
      "reference_id": "MONDO:0005275"
    }
  ],
  "children": [
    {
      "id": 16149,
      "label": "bronchiolitis obliterans syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4545,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2799",
          "EFO:0007183",
          "GARD:0005961",
          "HP:0011946",
          "ICD9:466.19",
          "ICD9:491.8",
          "MEDGEN:665",
          "NANDO:1200745",
          "NANDO:2100039",
          "NANDO:2200209",
          "Orphanet:1303",
          "SCTID:40100001",
          "UMLS:C0006272",
          "icd11.foundation:592711730"
        ],
        "synonyms": [
          "BOOP",
          "constrictive bronchiolitis",
          "organised pneumonia",
          "organized pneumonia",
          "bronchiolitis obliterans with obstructive pulmonary disease",
          "BO",
          "bronchiolitis exudativa",
          "bronchiolitis obliterans",
          "obliterative bronchiolitis",
          "organising pneumonia",
          "organizing pneumonia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung disorder that is mainly associated with chronic allograft dysfunction after lung transplantation and that is characterized by inflammation and fibrosis of bronchiolar walls that reduce the diameter of the bronchioles and result in progressive and irreversible airflow obstruction."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015265"
    },
    {
      "id": 20089,
      "label": "acute bronchiolitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4545,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:J21",
          "ICD10WHO:J21",
          "ICD9:466.1",
          "ICD9:466.19",
          "MEDGEN:113",
          "NCIT:C39659",
          "SCTID:5505005",
          "UMLS:C0001311",
          "icd11.foundation:1310075986"
        ],
        "synonyms": [
          "acute bronchiolitis",
          "Capillary pneumonia",
          "acute Bronchiolitis",
          "acute capillary bronchiolitis",
          "capillary pneumonia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Acute inflammation of the bronchioles usually caused by the respiratory syncytial virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020680"
    },
    {
      "id": 23872,
      "label": "toxic bronchiolitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4545
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Bronchiolitis as a response to a toxic exposure."
      },
      "child_count": 1,
      "reference_id": "MONDO:0100123"
    },
    {
      "id": 24023,
      "label": "respiratory syncytial virus bronchiolitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3780,
        4545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:547277",
          "UMLS:C0276340"
        ],
        "synonyms": [
          "RSV bronchiolitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Bronciolitis caused by infection with respiratory syncytial virus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100286"
    },
    {
      "id": 24826,
      "label": "postinfectious bronchiolitis obliterans",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1840786",
          "UMLS:C5830150"
        ],
        "synonyms": [
          "PIBO"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images. However, lung function tests using spirometry are not feasible in young children, and most cases of PIBO develop during early childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800119"
    },
    {
      "id": 24827,
      "label": "Mac-Leod-Swyer-James-Syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008324"
        ],
        "synonyms": [
          "SJS",
          "Swyer-James-(Macleod)-Syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare lung condition characterized by often predominantly unilateral lung hyperlucency and air trapping. The condition is a post-infectious form of bronchiolitis obliterans and typically follows a viral respiratory infection in infancy and childhood. Adenovirus infection is considered the most usual epidemiology. In SJS, the involved lung or portion of the lung does not grow normally and is slightly smaller than the opposite lung: in particular, peripheral branches of the pulmonary vessels do not develop, and vasculature is arreseted at the stage at which the infection occurred. Patients respond well to management with bronchodilators, even though this is not primarily a bronchial abnormality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800120"
    }
  ],
  "roots": [
    {
      "id": 6971,
      "label": "lung disorder"
    }
  ]
}