{
  "id": 4546,
  "label": "eye carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002466",
  "properties": {
    "xrefs": [
      "DOID:295",
      "MEDGEN:208855",
      "NCIT:C6079",
      "UMLS:C0848866"
    ],
    "synonyms": [
      "carcinoma of eye",
      "carcinoma of eyeball of camera-type eye",
      "carcinoma of the eye",
      "eye carcinoma",
      "eyeball of camera-type eye carcinoma",
      "ocular carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the eye"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4185,
      "label": "head and neck carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        7266
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1542",
          "MEDGEN:854345",
          "NCIT:C35850",
          "UMLS:C3887461"
        ],
        "synonyms": [
          "carcinoma of craniocervical region",
          "carcinoma of head and neck",
          "carcinoma of neck",
          "carcinoma of the head and neck",
          "craniocervical region carcinoma",
          "head and neck carcinoma",
          "neck carcinoma",
          "carcinoma of the neck",
          "head and neck cancer"
        ],
        "definition": "A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0002038"
    },
    {
      "id": 4353,
      "label": "ocular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3050,
        7266,
        20431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2174",
          "ICD9:190.8",
          "ICD9:239.89",
          "MEDGEN:105418",
          "MESH:D005134",
          "NCIT:C4767",
          "SCTID:371486001",
          "UMLS:C0496836"
        ],
        "synonyms": [
          "eye neoplasm",
          "neoplasm of eye",
          "ocular tumor",
          "ocular tumour",
          "cancer of eye",
          "cancer of eyeball of camera-type eye",
          "cancer of the eye",
          "eye cancer",
          "eye neoplasm, malignant",
          "eyeball of camera-type eye cancer",
          "malignant eye neoplasm",
          "malignant eye tumor",
          "malignant eye tumour",
          "malignant eyeball of camera-type eye neoplasm",
          "malignant neoplasm of eye",
          "malignant neoplasm of eyeball of camera-type eye",
          "malignant neoplasm of the eye",
          "malignant ocular neoplasm",
          "malignant ocular tumor",
          "malignant ocular tumour",
          "malignant tumor of eye",
          "malignant tumor of the eye",
          "malignant tumour of eye",
          "malignant tumour of the eye",
          "neoplasm of eye proper"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the structures of the eye."
      },
      "child_count": 30,
      "reference_id": "MONDO:0002236"
    }
  ],
  "children": [
    {
      "id": 3926,
      "label": "cornea squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        5677,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13538",
          "GARD:0022999",
          "MEDGEN:91102",
          "NCIT:C4552",
          "SCTID:255008003",
          "UMLS:C0346366"
        ],
        "synonyms": [
          "cornea epidermoid carcinoma",
          "cornea squamous cell carcinoma",
          "corneal epidermoid carcinoma",
          "corneal squamous cell carcinoma",
          "epidermoid carcinoma of cornea",
          "epidermoid carcinoma of the cornea",
          "squamous cell carcinoma of cornea",
          "squamous cell carcinoma of the cornea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare squamous cell carcinoma that arises from the cornea."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001740"
    },
    {
      "id": 4543,
      "label": "lacrimal gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4544,
        4546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:293",
          "MEDGEN:233606",
          "NCIT:C6129",
          "UMLS:C1334358"
        ],
        "synonyms": [
          "carcinoma of lacrimal gland",
          "carcinoma of the lacrimal gland",
          "lacrimal gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the lacrimal gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002463"
    },
    {
      "id": 5740,
      "label": "eyelid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4546,
        4707,
        20495
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6425",
          "MEDGEN:182526",
          "NCIT:C6078",
          "UMLS:C0920196"
        ],
        "synonyms": [
          "carcinoma of eyelid",
          "carcinoma of the eyelid",
          "eyelid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the eyelid."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003876"
    },
    {
      "id": 6443,
      "label": "eye carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        6433
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8792",
          "ICD10CM:D09.2",
          "ICD9:234.0",
          "MEDGEN:509519",
          "SCTID:92590009",
          "UMLS:C0154094"
        ],
        "synonyms": [
          "carcinoma in situ of eye",
          "carcinoma in situ of eyeball of camera-type eye",
          "eye in situ carcinoma",
          "eyeball of camera-type eye carcinoma in situ",
          "stage 0 eye carcinoma",
          "stage 0 eyeball of camera-type eye carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A carcinoma in situ involving a eye."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004659"
    },
    {
      "id": 7732,
      "label": "conjunctival squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        5378,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1748",
          "EFO:1000206",
          "GARD:0024318",
          "MEDGEN:87558",
          "NCIT:C4549",
          "SCTID:255003007",
          "UMLS:C0346359"
        ],
        "synonyms": [
          "ocular surface squamous neoplasia",
          "conjunctiva epidermoid carcinoma",
          "conjunctiva squamous cell carcinoma",
          "conjunctival epidermoid carcinoma",
          "conjunctival squamous cell cancer",
          "conjunctival squamous cell carcinoma",
          "epidermoid carcinoma of conjunctiva",
          "epidermoid carcinoma of the conjunctiva",
          "squamous cell carcinoma of conjunctiva",
          "squamous cell carcinoma of the conjunctiva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A low-grade squamous cell carcinoma that arises from the conjunctiva. It is the most common primary malignant tumor that arises from the conjunctiva. It usually affects older white males. Excessive exposure to sunlight is a risk factor. Patients may present with a mass, red eye, or pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006173"
    },
    {
      "id": 7860,
      "label": "ocular sebaceous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4546,
        8388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000405",
          "MEDGEN:317974",
          "NCIT:C43340",
          "UMLS:C1709308"
        ],
        "synonyms": [
          "eye sebaceous carcinoma",
          "ocular sebaceous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Ocular sebaceous carcinoma is a rare condition and accounts for 1% to 5.5% of eyelid malignancies and is the third most common eyelid malignancy after basal cell and squamous cell carcinoma. It usually affects elderly women, has a high rate of local recurrence, and a tendency to regional and distant metastases."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006327"
    },
    {
      "id": 15916,
      "label": "aniridia 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        4709,
        5006,
        8531,
        24259,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016200",
          "MEDGEN:138010",
          "MESH:C536372",
          "OMIM:617141",
          "SCTID:253232000",
          "UMLS:C0344543"
        ],
        "synonyms": [
          "AN2",
          "aniridia 2",
          "aniridia type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014937"
    },
    {
      "id": 15917,
      "label": "aniridia 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        4709,
        5006,
        8531,
        24259,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016201",
          "MEDGEN:934662",
          "OMIM:617142",
          "UMLS:C4310695"
        ],
        "synonyms": [
          "AN3",
          "TRIM44 isolated aniridia",
          "aniridia 3",
          "aniridia 3; AN3",
          "aniridia type 3",
          "isolated aniridia caused by mutation in TRIM44"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Any isolated aniridia in which the cause of the disease is a mutation in the TRIM44 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014938"
    },
    {
      "id": 24875,
      "label": "PAX6-related ocular dysgenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4546,
        5006,
        24259,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026474"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Any eye disorder in which the cause of the disease is a mutation in the PAX6 gene."
      },
      "child_count": 8,
      "reference_id": "MONDO:0800183"
    }
  ],
  "roots": [
    {
      "id": 4185,
      "label": "head and neck carcinoma"
    },
    {
      "id": 4353,
      "label": "ocular cancer"
    }
  ]
}