{
  "id": 4547,
  "label": "inner ear disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002467",
  "properties": {
    "xrefs": [
      "DOID:2952",
      "EFO:0009672",
      "ICD10CM:H80-H83",
      "MEDGEN:141671",
      "MESH:D007759",
      "NCIT:C27166",
      "SCTID:232297009",
      "UMLS:C0494559"
    ],
    "synonyms": [
      "disease of internal ear",
      "disease or disorder of internal ear",
      "disorder of internal ear",
      "inner Ear disorder",
      "internal Ear disorder",
      "internal ear disease",
      "internal ear disease or disorder",
      "vestibular disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0002409",
        "name": "auditory system disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 15,
  "parents": [
    {
      "id": 4499,
      "label": "auditory system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2742",
          "EFO:1001455",
          "ICD10CM:H60-H95",
          "MEDGEN:1846617",
          "SCTID:362966006",
          "UMLS:C5848260"
        ],
        "synonyms": [
          "auditory disease",
          "auditory system disease",
          "auditory system disease or disorder",
          "disease of auditory system",
          "disease or disorder of auditory system",
          "disorder of auditory system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          }
        ],
        "definition": "A disease involving the auditory system."
      },
      "child_count": 11,
      "reference_id": "MONDO:0002409"
    },
    {
      "id": 20423,
      "label": "disorder of ear",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:388.8",
          "ICD9:388.9",
          "MEDGEN:3946",
          "NCIT:C26757",
          "SCTID:25906001",
          "UMLS:C0013447"
        ],
        "synonyms": [
          "Ear disease",
          "Ear disorder",
          "disease of ear",
          "disease or disorder of ear",
          "disorder of ear",
          "ear disease",
          "ear disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A disease that involves the ear."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021205"
    }
  ],
  "children": [
    {
      "id": 4071,
      "label": "bilateral hyperactive labyrinth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14165",
          "ICD9:386.52",
          "MEDGEN:510002",
          "SCTID:194373002",
          "UMLS:C0155516"
        ],
        "synonyms": [
          "hyperactive labyrinth, bilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001897"
    },
    {
      "id": 4125,
      "label": "labyrinthine bilateral reactive loss",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14413",
          "ICD9:386.56",
          "MEDGEN:510006",
          "SCTID:194377001",
          "UMLS:C0155520"
        ],
        "synonyms": [
          "loss of labyrinthine reactivity, bilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001959"
    },
    {
      "id": 4163,
      "label": "labyrinthitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1468",
          "DOID:3930",
          "EFO:0009604",
          "ICD10CM:H83.0",
          "ICD9:386.3",
          "ICD9:386.30",
          "MEDGEN:5991",
          "MESH:D007762",
          "NCIT:C128369",
          "SCTID:23919004",
          "UMLS:C0022893",
          "icd11.foundation:901550793"
        ],
        "synonyms": [
          "inflammation of internal ear",
          "internal ear inflammation",
          "otitis interna",
          "inner ear infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002008"
    },
    {
      "id": 4243,
      "label": "labyrinthine unilateral reactive loss",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1776",
          "ICD9:386.55",
          "MEDGEN:510005",
          "UMLS:C0155519"
        ],
        "synonyms": [
          "loss of labyrinthine reactivity, unilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002106"
    },
    {
      "id": 4244,
      "label": "unilateral hyperactive labyrinth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1777",
          "ICD9:386.51",
          "MEDGEN:510001",
          "UMLS:C0155515"
        ],
        "synonyms": [
          "hyperactive labyrinth, unilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002107"
    },
    {
      "id": 4694,
      "label": "vestibular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        18957,
        21402
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3426",
          "EFO:0009691",
          "MEDGEN:12079",
          "MESH:D015837",
          "UMLS:C0042594"
        ],
        "synonyms": [
          "disease of vestibular labyrinth",
          "disease of vestibular system",
          "disease or disorder of vestibular labyrinth",
          "disorder of vestibular labyrinth",
          "vestibular labyrinth disease",
          "vestibular labyrinth disease or disorder",
          "vestibular system disease",
          "disorder of vestibular system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002643"
    },
    {
      "id": 5376,
      "label": "cochlear disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547,
        21562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5463",
          "MEDGEN:1023",
          "MESH:D015834",
          "UMLS:C0009197"
        ],
        "synonyms": [
          "cochlea disease",
          "cochlea disease or disorder",
          "disease of cochlea",
          "disease or disorder of cochlea",
          "disorder of cochlea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Pathological processes of the snail-like structure (cochlea) of the inner ear (labyrinth) which can involve its nervous tissue, blood vessels, or fluid (endolymph)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003452"
    },
    {
      "id": 5467,
      "label": "bilateral hypoactive labyrinth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:565",
          "ICD9:386.54",
          "MEDGEN:510004",
          "SCTID:194375009",
          "UMLS:C0155518"
        ],
        "synonyms": [
          "hypoactive labyrinth, bilateral"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0003567"
    },
    {
      "id": 6565,
      "label": "unilateral hypoactive labyrinth",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9496",
          "ICD9:386.53",
          "MEDGEN:510003",
          "UMLS:C0155517"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004801"
    },
    {
      "id": 7034,
      "label": "otosclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12185",
          "EFO:0004213",
          "GARD:0027719",
          "HP:0000362",
          "ICD10CM:H80",
          "ICD10WHO:H80",
          "ICD9:387",
          "ICD9:387.8",
          "ICD9:387.9",
          "MEDGEN:10508",
          "MESH:D010040",
          "NCIT:C185242",
          "OMIMPS:166800",
          "Orphanet:2794",
          "SCTID:11543004",
          "UMLS:C0029899",
          "icd11.foundation:1242649410"
        ],
        "synonyms": [
          "otosclerosis",
          "otosclerosis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs."
      },
      "child_count": 33,
      "reference_id": "MONDO:0005349"
    },
    {
      "id": 9341,
      "label": "motion sickness",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        18718,
        22991
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2951",
          "ICD10CM:T75.3",
          "ICD9:994.6",
          "MEDGEN:44503",
          "MESH:D009041",
          "OMIM:158280",
          "UMLS:C0026603",
          "icd11.foundation:1078108554"
        ],
        "synonyms": [
          "motion sickness",
          "travel sickness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A sensation of discomfort that results from a discordant relationship between visualized movement and any movement sensed by the vestibular system, which is characterized by dizziness, nausea, and vomiting."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008015"
    },
    {
      "id": 11730,
      "label": "X-linked mixed hearing loss with perilymphatic gusher",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4547,
        16853,
        18718,
        19391
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111737",
          "GARD:0004504",
          "ICD9:389.1",
          "ICD9:389.10",
          "ICD9:389.14",
          "MEDGEN:336750",
          "MedDRA:10040016",
          "OMIM:304400",
          "Orphanet:383",
          "UMLS:C1844678"
        ],
        "synonyms": [
          "central hearing loss",
          "high frequency deafness",
          "high frequency hearing loss",
          "high-frequency hearing loss",
          "perceptive deafness",
          "perceptive hearing loss",
          "perceptive hearing loss or deafness",
          "sensorineural deafness",
          "sensorineural hearing loss",
          "sensory hearing loss",
          "DFNX2",
          "X-linked mixed hearing loss with perilymphatic gusher",
          "Nance deafness",
          "X-linked deafness type 2",
          "X-linked mixed conductive and neurosensory deafness",
          "X-linked mixed conductive and sensorineural deafness",
          "X-linked mixed deafness with perilymphatic gusher",
          "conductive deafness with stapes fixation",
          "deafness mixed with perilymphatic gusher, X-linked",
          "deafness, X-linked 2, X-linked recessive",
          "deafness, X-linked type 2",
          "DFN 3 nonsyndromic hearing loss and deafness",
          "DFN3",
          "deafness 3 conductive with stapes fixation",
          "deafness 3, conductive, with stapes fixation",
          "deafness conductive with stapes fixation",
          "deafness mixed with perilymphatic gusher",
          "deafness, X-linked 2",
          "deafness, conductive, with stapes fixation",
          "deafness, mixed, with perilymphatic gusher",
          "gusher syndrome",
          "perilymphatic gusher-deafness syndrome",
          "sensorineural deafness, profound, with or without a conductive component, associated with a unique developmental Abnormality of the Ear"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "X-linked mixed deafness with perilymphatic gusher, also known as X-linked deafness type 2, is a rare form of non-syndromic genetic deafnesss affecting males and characterized by pathognomonic inner ear anomalies and conductive and profound sensorineural hearing loss. The inner ear anomalies are described as dilatation of the internal auditory meatus and fistulous connection between the cochlear basal turn and internal auditory canal resulting in perilympatic gusher on attempted mobilization of a fixed stapes. Obligate female carriers may suffer from mild to moderate hearing loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010576"
    },
    {
      "id": 20878,
      "label": "autoimmune inner ear disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3003,
        4547
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:583162",
          "UMLS:C0395947",
          "icd11.foundation:1392879169"
        ],
        "synonyms": [
          "AIED"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A syndrome characterized by rapidly progressive sensorineural hearing loss (SNHL), that is often bilateral, and is potentially reversible."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022518"
    },
    {
      "id": 21122,
      "label": "enlarged vestibular aqueduct syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        4547,
        21562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050332",
          "MEDGEN:355050",
          "UMLS:C1863752"
        ],
        "synonyms": [
          "enlarged vestibular aqueduct syndrome",
          "enlarged vestibular aqueduct",
          "large vestibular aqueduct syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023069"
    },
    {
      "id": 21352,
      "label": "inner ear neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4547,
        20443
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:268582",
          "NCIT:C39784",
          "UMLS:C1512779"
        ],
        "synonyms": [
          "inner Ear neoplasm",
          "internal Ear neoplasm",
          "internal ear neoplasm",
          "internal ear neoplasm (disease)",
          "internal ear tumor",
          "internal ear tumour",
          "neoplasm of internal ear",
          "tumor of internal ear",
          "tumour of internal ear"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare neoplasm that arises from the inner ear. Representative examples include lipoma and acoustic schwannoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024320"
    }
  ],
  "roots": [
    {
      "id": 4499,
      "label": "auditory system disorder"
    },
    {
      "id": 20423,
      "label": "disorder of ear"
    }
  ]
}