{
  "id": 4552,
  "label": "carcinoma ex pleomorphic adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002472",
  "properties": {
    "xrefs": [
      "ICDO:8941/3",
      "MEDGEN:87486",
      "NCIT:C4397",
      "UMLS:C0344460"
    ],
    "synonyms": [
      "carcinoma ex pleomorphic adenoma",
      "carcinoma ex pleomorphic adenoma (morphologic abnormality)",
      "carcinoma in pleomorphic adenoma"
    ],
    "definition": "A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs in the parotid gland and less often in the submandibular gland and minor salivary gland. Patients usually present with a history of a long-standing mass which recently had undergone rapid growth. The prognosis depends on the invasiveness of the malignant component. Patients with non-invasive or minimally invasive tumors usually have a good prognosis following surgical resection. Invasive tumors are usually aggressive and are associated with recurrences and metastases."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4477,
      "label": "myoepithelial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2661",
          "ICDO:8982/0",
          "ICDO:8982/1",
          "MEDGEN:10235",
          "MESH:D009208",
          "NCIT:C40392",
          "UMLS:C0027070"
        ],
        "synonyms": [
          "myoepithelial neoplasm",
          "myoepithelial tumor",
          "myoepithelioma",
          "benign myoepithelioma"
        ],
        "definition": "A benign or malignant tumor characterized by the presence of cells that show myoepithelial differentiation. Based on its morphologic features, it is classified as benign or malignant. A representative example of benign myoepithelioma is benign salivary gland myoepithelioma. Representative examples of malignant myoepithelioma or myoepithelial carcinoma are malignant breast myoepithelioma and salivary gland myoepithelial carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002380"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:154",
          "EFO:1000356",
          "ICDO:8940/3",
          "MEDGEN:64618",
          "MESH:D018198",
          "NCIT:C3729",
          "UMLS:C0206625"
        ],
        "synonyms": [
          "mixed cell type cancer",
          "mixed neoplasm",
          "mixed tumor",
          "mixed tumour",
          "malignant mixed neoplasm",
          "malignant mixed tumor",
          "malignant mixed tumour",
          "mixed neoplasm, malignant",
          "mixed tumor, malignant (morphologic abnormality)",
          "mixed tumor, malignant, NOS (morphologic abnormality)",
          "tumor, mixed, malignant",
          "malignant mixed tumors",
          "malignant mixed tumours",
          "mixed tumors, malignant",
          "tumor, malignant mixed",
          "tumors, malignant mixed"
        ],
        "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005853"
    }
  ],
  "children": [
    {
      "id": 4549,
      "label": "lacrimal gland carcinoma ex pleomorphic adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4543,
        4552
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:296",
          "MEDGEN:138058",
          "NCIT:C6804",
          "SCTID:254989000",
          "UMLS:C0346342"
        ],
        "synonyms": [
          "carcinoma Ex pleomorphic adenoma of the lacrimal gland",
          "carcinoma ex pleomorphic adenoma of lacrimal gland",
          "carcinoma ex pleomorphic adenoma of the lacrimal gland",
          "lacrimal gland carcinoma ex pleomorphic adenoma",
          "lacrimal gland malignant mixed neoplasm",
          "lacrimal gland malignant mixed tumor",
          "lacrimal gland malignant mixed tumour",
          "malignant mixed neoplasm of lacrimal gland",
          "malignant mixed neoplasm of the lacrimal gland",
          "malignant mixed tumor of lacrimal gland",
          "malignant mixed tumor of the lacrimal gland",
          "malignant mixed tumour of lacrimal gland",
          "malignant mixed tumour of the lacrimal gland",
          "mixed lacrimal gland cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A carcinoma arising in a pre-existing pleomorphic adenoma in the lacrimal gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002469"
    },
    {
      "id": 7922,
      "label": "salivary gland carcinoma ex pleomorphic adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2972,
        4552
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:297",
          "EFO:1000516",
          "GARD:0027752",
          "MEDGEN:274190",
          "NCIT:C40410",
          "UMLS:C1519172"
        ],
        "synonyms": [
          "saliva-secreting gland carcinoma ex pleomorphic adenoma",
          "salivary gland carcinoma ex pleomorphic adenoma",
          "pleomorphic adenoma carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A carcinoma that arises from a pleomorphic adenoma in the salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006403"
    }
  ],
  "roots": [
    {
      "id": 4477,
      "label": "myoepithelial tumor"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm"
    }
  ]
}