{
  "id": 4564,
  "label": "breast neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002485",
  "properties": {
    "xrefs": [
      "DOID:3009",
      "GARD:0023146",
      "MEDGEN:231969",
      "NCIT:C5169",
      "UMLS:C1332635"
    ],
    "synonyms": [
      "breast NET",
      "breast endocrine neoplasm",
      "breast neuroendocrine neoplasm",
      "breast neuroendocrine tumor",
      "breast neuroendocrine tumor, well differentiated, low or intermediate grade",
      "breast neuroendocrine tumour",
      "neuroendocrine neoplasm of breast",
      "neuroendocrine neoplasm of the breast",
      "neuroendocrine tumour of the breast"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm that arises from the breast and is composed of cells of neuroendocrine origin. Most cases are neuroendocrine carcinomas. Primary carcinoid tumors of the breast are very rare."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    },
    {
      "id": 20340,
      "label": "breast neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708,
        20518
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003869",
          "ICD9:239.3",
          "MEDGEN:264172",
          "MESH:D001943",
          "NCIT:C2910",
          "ONCOTREE:BREAST",
          "SCTID:126926005",
          "UMLS:C1458155"
        ],
        "synonyms": [
          "breast neoplasm",
          "breast neoplasm (disease)",
          "breast tumor",
          "breast tumour",
          "neoplasm of breast",
          "neoplasm of the breast",
          "neoplasm, breast",
          "tumor of breast",
          "tumor of the breast",
          "tumour of breast",
          "tumour of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021100"
    }
  ],
  "children": [
    {
      "id": 5817,
      "label": "breast large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4564,
        6787,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6657",
          "GARD:0023753",
          "MEDGEN:307310",
          "NCIT:C40356",
          "UMLS:C1511316"
        ],
        "synonyms": [
          "breast large cell neuroendocrine carcinoma",
          "large cell neuroendocrine carcinoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A poorly differentiated neuroendocrine carcinoma that arises from the breast. It is characterized by the presence of large neuroendocrine cells and high mitotic activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003959"
    }
  ],
  "roots": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    },
    {
      "id": 20340,
      "label": "breast neoplasm"
    }
  ]
}