{
  "id": 4565,
  "label": "lobular neoplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002486",
  "properties": {
    "xrefs": [
      "DOID:3010",
      "MEDGEN:167824",
      "NCIT:C27939",
      "UMLS:C0861352"
    ],
    "synonyms": [
      "LIN",
      "LN",
      "lobular intraepithelial neoplasia",
      "lobular neoplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A spectrum of non-invasive neoplastic lesions that arise from the terminal ductal lobular units of the breast. There is atypical small epithelial cell proliferation. Pagetoid involvement of the terminal ducts may or may not be present. In the minority of cases, there is a risk for subsequent development of invasive ductal or invasive lobular carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6442,
      "label": "breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8791",
          "ICD10CM:D05",
          "ICD9:233.0",
          "MEDGEN:57817",
          "MESH:D000071960",
          "NCIT:C3641",
          "SCTID:189336000",
          "UMLS:C0154084",
          "icd11.foundation:1264360394"
        ],
        "synonyms": [
          "breast cancer in situ",
          "breast cancer stage 0",
          "breast carcinoma in situ",
          "breast in situ carcinoma",
          "carcinoma in situ of breast",
          "carcinoma in situ of the breast",
          "in situ breast cancer",
          "non-infiltrating breast carcinoma",
          "non-infiltrating carcinoma of breast",
          "non-infiltrating carcinoma of the breast",
          "non-invasive breast carcinoma",
          "non-invasive carcinoma of breast",
          "non-invasive carcinoma of the breast",
          "stage 0 breast cancer",
          "stage 0 breast cancer aJCC v6",
          "stage 0 breast cancer aJCC v6 and v7",
          "stage 0 breast cancer aJCC v7",
          "stage 0 breast carcinoma",
          "stage 0 breast carcinoma in situ",
          "stage 0 carcinoma of breast",
          "stage 0 carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A in situ carcinoma that involves the breast."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004658"
    }
  ],
  "children": [
    {
      "id": 7672,
      "label": "atypical lobular breast hyperplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3053,
        4565,
        6775
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000100",
          "ICD9:610.8",
          "MEDGEN:277968",
          "NCIT:C4730",
          "SCTID:450697004",
          "UMLS:C1368920"
        ],
        "synonyms": [
          "ALH",
          "atypical breast lobular hyperplasia",
          "atypical lobular breast hyperplasia",
          "atypical lobular hyperplasia",
          "atypical lobular hyperplasia of breast",
          "atypical lobular hyperplasia of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Lobular neoplasia characterized by lobular epithelial proliferation that does not completely fill the lobular unit of the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006098"
    },
    {
      "id": 7813,
      "label": "lobular breast carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4565,
        5172,
        6729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000326",
          "ICD10CM:D05.0",
          "ICDO:8520/2",
          "MEDGEN:79007",
          "NCIT:C4018",
          "ONCOTREE:LCIS",
          "SCTID:109888004",
          "UMLS:C0279563"
        ],
        "synonyms": [
          "LCIS",
          "lobular Ca in situ of breast",
          "lobular Ca in situ of the breast",
          "lobular breast carcinoma in situ",
          "lobular carcinoma in situ",
          "lobular carcinoma in situ (LCIS)",
          "lobular carcinoma in situ of breast",
          "lobular carcinoma in situ of the breast",
          "lobular carcinoma in situ of the breast (LCIS)",
          "non-infiltrating lobular breast carcinoma",
          "non-infiltrating lobular carcinoma",
          "non-infiltrating lobular carcinoma of breast",
          "non-infiltrating lobular carcinoma of the breast",
          "non-invasive lobular breast carcinoma",
          "non-invasive lobular carcinoma of breast",
          "non-invasive lobular carcinoma of the breast",
          "breast lobular carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006270"
    }
  ],
  "roots": [
    {
      "id": 6442,
      "label": "breast carcinoma in situ"
    }
  ]
}