{
  "id": 4576,
  "label": "brain glioblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002501",
  "properties": {
    "xrefs": [
      "DOID:3073",
      "EFO:0006545",
      "GARD:0023150",
      "MEDGEN:138100",
      "NCIT:C4642",
      "SCTID:276828006",
      "UMLS:C0349543"
    ],
    "synonyms": [
      "brain glioblastoma",
      "brain glioblastoma (disease)",
      "brain glioblastoma multiforme",
      "brain glioblastoma multiforme (disease)",
      "glioblastoma multiforme of brain",
      "glioblastoma multiforme of the brain",
      "grade IV astrocytic tumour of brain",
      "grade IV brain astrocytic tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7155,
      "label": "brain glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060108",
          "GARD:0024195",
          "MEDGEN:91163",
          "NCIT:C162993",
          "SCTID:254937005",
          "UMLS:C0349661"
        ],
        "synonyms": [
          "brain malignant glioma",
          "malignant glioma of brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant glioma that involves the brain."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005499"
    },
    {
      "id": 18320,
      "label": "glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3068",
          "EFO:0000519",
          "GARD:0002491",
          "HP:0012174",
          "HP:0100843",
          "ICDO:9440/3",
          "MEDGEN:42228",
          "MESH:D005909",
          "MedDRA:10018336",
          "MedDRA:10018337",
          "NANDO:2200087",
          "NCIT:C3058",
          "NORD:1187",
          "ONCOTREE:GB",
          "ONCOTREE:GBM",
          "Orphanet:360",
          "SCTID:393563007",
          "UMLS:C0017636"
        ],
        "synonyms": [
          "GBM",
          "GBM (glioblastoma)",
          "WHO grade IV glioma",
          "glioblastoma",
          "glioblastoma (disease)",
          "glioblastoma multiforme",
          "glioblastoma multiforme (disease)",
          "grade IV astrocytic neoplasm",
          "grade IV astrocytic tumor",
          "grade IV astrocytic tumour",
          "grade IV astrocytoma",
          "spongioblastoma multiforme",
          "grade IV adult astrocytic tumor",
          "grade IV adult astrocytic tumour",
          "giant cell glioblastoma (histologic variant)",
          "gliosarcoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)"
      },
      "child_count": 7,
      "reference_id": "MONDO:0018177"
    }
  ],
  "children": [
    {
      "id": 17145,
      "label": "gliosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4576
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3071",
          "EFO:1001465",
          "GARD:0005653",
          "ICDO:9442/3",
          "MEDGEN:64638",
          "MESH:D018316",
          "MedDRA:10018340",
          "NCIT:C3796",
          "ONCOTREE:GSARC",
          "Orphanet:251576",
          "UMLS:C0206726"
        ],
        "synonyms": [
          "glioblastoma with a sarcomatous component",
          "gliosarcoma",
          "sarcomatous glioblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare histological variant of glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation (WHO)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016681"
    },
    {
      "id": 17146,
      "label": "giant cell glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4576
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3074",
          "GARD:0020705",
          "ICDO:9441/3",
          "MEDGEN:83169",
          "NCIT:C4325",
          "Orphanet:251579",
          "UMLS:C0334588",
          "icd11.foundation:565094124"
        ],
        "synonyms": [
          "Monstrocellular sarcoma [obs]"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016682"
    },
    {
      "id": 29342,
      "label": "brain stem glioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4576,
        4918
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028180",
          "MEDGEN:231460",
          "NCIT:C5097",
          "UMLS:C1332610"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glioblastoma localized in the brain stem."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060180"
    }
  ],
  "roots": [
    {
      "id": 7155,
      "label": "brain glioma"
    },
    {
      "id": 18320,
      "label": "glioblastoma"
    }
  ]
}