{
  "id": 4583,
  "label": "papillary adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002512",
  "properties": {
    "xrefs": [
      "DOID:3112",
      "ICDO:8260/3",
      "MEDGEN:123",
      "MESH:D000231",
      "NCIT:C2853",
      "UMLS:C0001420"
    ],
    "synonyms": [
      "adenocarcinoma, papillary, malignant",
      "papillary adenocarcinoma",
      "papillary adenocarcinoma (morphologic abnormality)",
      "papillary adenocarcinoma NOS (morphologic abnormality)",
      "infiltrating and papillary adenocarcinoma",
      "infiltrating papillary adenocarcinoma"
    ],
    "definition": "A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 8000,
      "label": "papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        20336
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3113",
          "EFO:1000646",
          "ICDO:8050/3",
          "MEDGEN:40105",
          "MESH:D002291",
          "NCIT:C2927",
          "UMLS:C0007133"
        ],
        "synonyms": [
          "papillary carcinoma",
          "papillary carcinoma (morphologic abnormality)",
          "papillary carcinoma NOS (morphologic abnormality)"
        ],
        "definition": "A malignant epithelial neoplasm characterized by a papillary growth pattern. A papillary carcinoma may be composed of glandular cells (papillary adenocarcinoma), squamous cells (papillary squamous cell carcinoma), or transitional cells (papillary transitional cell carcinoma). Bladder carcinoma is a representative example of papillary transitional cell carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0006509"
    }
  ],
  "children": [
    {
      "id": 5439,
      "label": "papillary eccrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        21295
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5591",
          "NCIT:C27254",
          "SCTID:254709009"
        ],
        "synonyms": [
          "papillary apocrine fibroadenoma",
          "papillary eccrine adenoma",
          "papillary eccrine carcinoma",
          "tubular apocrine adenoma",
          "digital papillary adenocarcinoma",
          "eccrine papillary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0003531"
    },
    {
      "id": 5440,
      "label": "breast papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5592",
          "MEDGEN:818226",
          "NCIT:C9134",
          "UMLS:C3812899"
        ],
        "synonyms": [
          "Papillary breast cancer",
          "breast papillary carcinoma",
          "papillary breast carcinoma",
          "papillary carcinoma of breast",
          "papillary carcinoma of the breast",
          "breast solid papillary carcinoma",
          "solid papillary carcinoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast carcinoma characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003532"
    },
    {
      "id": 5441,
      "label": "papillary thymic adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        5165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5595",
          "GARD:0023550",
          "MEDGEN:233836",
          "NCIT:C27937",
          "UMLS:C1335327"
        ],
        "synonyms": [
          "Thymus papillary carcinoma",
          "papillary carcinoma of Thymus",
          "papillary carcinoma of the Thymus",
          "thymic papillary adenocarcinoma",
          "thymic papillary carcinoma",
          "thymus papillary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic adenocarcinoma, characterized by a papillary growth pattern. There are only a few published cases, and no good data regarding prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003534"
    },
    {
      "id": 5442,
      "label": "fallopian tube papillary adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        4781
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5597",
          "GARD:0023551",
          "MEDGEN:234261",
          "NCIT:C6267",
          "UMLS:C1333595"
        ],
        "synonyms": [
          "fallopian tube papillary adenocarcinoma",
          "papillary adenocarcinoma of fallopian tube"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the fallopian tube and is characterized by a papillary architectural pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003535"
    },
    {
      "id": 5738,
      "label": "ovarian serous surface papillary adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        5686,
        6927
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6408",
          "GARD:0023708",
          "MEDGEN:233279",
          "NCIT:C6256",
          "UMLS:C1335178"
        ],
        "synonyms": [
          "ovarian serous surface papillary adenocarcinoma",
          "ovary papillary carcinoma",
          "serous surface papillary carcinoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A serous adenocarcinoma that arises from the ovary and is characterized by the presence of a papillary architectural pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003874"
    },
    {
      "id": 5975,
      "label": "gallbladder papillary neoplasm with an associated invasive carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        4589,
        7768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7221",
          "GARD:0023849",
          "ICDO:8503/3",
          "MEDGEN:232226",
          "NCIT:C5743",
          "UMLS:C1333753"
        ],
        "synonyms": [
          "gall bladder papillary carcinoma",
          "gallbladder papillary neoplasm with an associated invasive cancer",
          "gallbladder papillary neoplasm with an associated invasive carcinoma",
          "intracystic papillary neoplasm with an associated invasive carcinoma",
          "papillary carcinoma of gallbladder",
          "papillary carcinoma of the gallbladder",
          "gallbladder papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An intraluminal papillary neoplasm, usually with high grade intraepithelial neoplasia, that arises from the gallbladder. It is associated with the presence of an invasive carcinoma. The carcinomatous component is usually an adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004148"
    },
    {
      "id": 6802,
      "label": "papillary cystadenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7240,
        7875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3110",
          "EFO:0000639",
          "ICDO:8450/3",
          "MEDGEN:64635",
          "MESH:D018283",
          "NCIT:C3777",
          "UMLS:C0206700"
        ],
        "synonyms": [
          "cystadenocarcinoma, papillary, malignant",
          "papillary cystadenocarcinoma",
          "papillary cystadenocarcinoma (morphologic abnormality)",
          "papillary cystadenocarcinoma, NOS (morphologic abnormality)"
        ],
        "definition": "A malignant cystic serous or mucinous epithelial neoplasm characterized by the presence of malignant glandular epithelial cells forming papillary structures. Stromal invasion is present."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005074"
    },
    {
      "id": 6803,
      "label": "thyroid gland papillary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        16290,
        21537
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3969",
          "EFO:0000641",
          "GARD:0024148",
          "HP:0002895",
          "MEDGEN:66773",
          "NCIT:C4035",
          "ONCOTREE:THPA",
          "SCTID:255029007",
          "UMLS:C0238463"
        ],
        "synonyms": [
          "papillary cancer of the thyroid",
          "papillary cancer of the thyroid gland",
          "papillary cancer of thyroid",
          "papillary cancer of thyroid gland",
          "papillary carcinoma of the thyroid",
          "papillary carcinoma of the thyroid gland",
          "papillary carcinoma of thyroid",
          "papillary carcinoma of thyroid gland",
          "papillary thyroid cancer",
          "papillary thyroid carcinoma",
          "papillary thyroid gland carcinoma",
          "thyroid gland papillary cancer",
          "thyroid gland papillary carcinoma",
          "thyroid papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005075"
    },
    {
      "id": 7634,
      "label": "papillary lung adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5588",
          "EFO:1000046",
          "GARD:0024275",
          "ICD9:162.9",
          "MEDGEN:277495",
          "NCIT:C5650",
          "SCTID:707411007",
          "UMLS:C1335325"
        ],
        "synonyms": [
          "lung papillary adenocarcinoma",
          "lung papillary-adenocarcinoma",
          "papillary adenocarcinoma of lung",
          "papillary adenocarcinoma of the lung",
          "papillary lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of papillary structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006049"
    },
    {
      "id": 7781,
      "label": "gastric papillary adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        6770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5593",
          "EFO:1000276",
          "GARD:0027744",
          "MEDGEN:232550",
          "NCIT:C5472",
          "ONCOTREE:PSTAD",
          "UMLS:C1333785"
        ],
        "synonyms": [
          "gastric papillary adenocarcinoma",
          "papillary adenocarcinoma of stomach",
          "papillary adenocarcinoma of the stomach",
          "stomach papillary adenocarcinoma",
          "papillary stomach adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006228"
    },
    {
      "id": 18097,
      "label": "papillary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4465",
          "EFO:0000640",
          "GARD:0009572",
          "MEDGEN:266300",
          "NCIT:C6975",
          "ONCOTREE:PRCC",
          "Orphanet:319298",
          "SCTID:733608000",
          "UMLS:C1306837"
        ],
        "synonyms": [
          "HPRCC",
          "chromophil carcinoma of kidney",
          "chromophil carcinoma of the kidney",
          "chromophil renal cell carcinoma",
          "papillary (chromophil) renal cell carcinoma",
          "papillary renal cell adenocarcinoma",
          "papillary renal cell cancer",
          "papillary renal cell carcinoma",
          "renal cell carcinoma, papillary, type 1",
          "RCCP",
          "RCCP1",
          "chromophil RCC",
          "papillary renal carcinoma, malignant - (subtype)",
          "papillary renal cell carcinoma, bilateral - (subtype)",
          "papillary renal cell carcinoma, familial - (subtype)",
          "papillary renal cell carcinoma, multiple - (subtype)",
          "papillary renal cell carcinoma, sporadic - (subtype)",
          "renal adenocarcinoma",
          "renal cell carcinoma, papillary, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017884"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 8000,
      "label": "papillary carcinoma"
    }
  ]
}