{ "id": 4587, "label": "digestive system cancer", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0002516", "properties": { "xrefs": [ "DOID:3119", "ICD10CM:C15-C26", "ICD9:239.0", "MEDGEN:148231", "NCIT:C4890", "UMLS:C0751075" ], "synonyms": [ "GI tumor", "GI tumour", "cancer of digestive system", "digestive system cancer", "gastrointestinal system cancer", "malignant digestive system neoplasm", "malignant gastrointestinal neoplasm", "malignant gastrointestinal system neoplasm", "malignant neoplasm of digestive system" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving any part of the digestive system." }, "isLeaf": false, "isRoot": false, "child_count": 15, "parents": [ { "id": 6151, "label": "digestive system disorder", "isLeaf": false, "isRoot": false, "parents": [ 29379 ], "type_id": 0, "properties": { "xrefs": [ "DOID:77", "ICD10CM:K00-K95", "ICD9:520-579", "ICD9:V47.3", "MEDGEN:892790", "MESH:D005767", "NANDO:1100013", "NCIT:C2990", "SCTID:53619000", "UMLS:C4023588", "icd11.foundation:1256772020" ], "synonyms": [ "digestive disease", "digestive system disease", "digestive system disease or disorder", "digestive system disorder", "disease of digestive system", "disease or disorder of digestive system", "disorder of digestive system", "gastroenterological system disease", "gastroenterological system disorder", "gastrointestinal disorder", "gastrointestinal system disease", "gastrointestinal system disorder", "stomach or intestinal disorder" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A disease or disorder that involves the digestive system." }, "child_count": 31, "reference_id": "MONDO:0004335" }, { "id": 6733, "label": "cancer", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050686", "DOID:0050687", "DOID:162", "ICD9:195.8", "ICD9:199", "ICD9:199.1", "ICDO:8000/3", "MEDGEN:14297", "NCIT:C9305", "ONCOTREE:MT", "SCTID:363346000", "UMLS:C0006826", "birnlex:406" ], "synonyms": [ "CA", "cancer", "cell type cancer", "malignancy", "malignant growth", "malignant neoplasm", "malignant neoplasm (disease)", "malignant neoplastic disease", "malignant tumor", "malignant tumour", "neoplasm (disease), malignant", "neoplasm, malignant", "MT" ], "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas." }, "child_count": 33, "reference_id": "MONDO:0004992" }, { "id": 20434, "label": "digestive system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 6798 ], "type_id": 0, "properties": { "xrefs": [ "EFO:0008549", "MEDGEN:8398", "MESH:D005770", "NCIT:C3052", "UMLS:C0012243" ], "synonyms": [ "GI neoplasm", "GI system neoplasm", "GI system tumor", "GI system tumour", "GI tumor", "GI tumour", "digestive neoplasm", "digestive system neoplasm (disease)", "digestive system tumor", "digestive system tumour", "digestive tumor", "digestive tumour", "gastrointestinal neoplasm", "gastrointestinal system neoplasm", "gastrointestinal system tumor", "gastrointestinal system tumour", "gastrointestinal tumor", "gastrointestinal tumour", "neoplasm of GI system", "neoplasm of digestive system", "neoplasm of gastrointestinal system", "neoplasm of the GI system", "neoplasm of the digestive system", "neoplasm of the gastrointestinal system", "tumor of GI system", "tumor of digestive system", "tumor of gastrointestinal system", "tumor of the GI system", "tumor of the digestive system", "tumor of the gastrointestinal system", "tumour of GI system", "tumour of digestive system", "tumour of gastrointestinal system", "tumour of the GI system", "tumour of the digestive system", "tumour of the gastrointestinal system" ], "definition": "A neoplasm (disease) that involves the digestive system." }, "child_count": 23, "reference_id": "MONDO:0021223" } ], "children": [ { "id": 3312, "label": "gastric cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20326 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10534", "GARD:0007704", "ICD10CM:C16", "ICD9:151", "ICD9:151.4", "ICD9:151.5", "ICD9:151.6", "ICD9:151.9", "MEDGEN:44264", "NCIT:C9331", "OMIM:613659", "UMLS:C0024623", "icd11.foundation:1397617262" ], "synonyms": [ "gastric neoplasm", "Ca lesser curvature - stomach", "GC", "cancer of stomach", "gastric cancer", "gastric cancer risk after h. pylori infection", "gastric cancer, somatic", "malignant gastric neoplasm", "malignant gastric tumor", "malignant gastric tumour", "malignant neoplasm of lesser curve of stomach", "malignant neoplasm of stomach", "malignant neoplasm of the stomach", "malignant stomach neoplasm", "malignant tumor of body of stomach", "malignant tumor of greater curve of stomach", "malignant tumor of lesser curve of stomach", "malignant tumor of stomach", "malignant tumor of the stomach", "malignant tumour of body of stomach", "malignant tumour of greater curve of stomach", "malignant tumour of lesser curve of stomach", "malignant tumour of stomach", "malignant tumour of the stomach", "stomach cancer", "Ca body - stomach", "ca greater curvature of stomach", "malignant neoplasm of body of stomach", "gastric cancer, intestinal" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the stomach." }, "child_count": 18, "reference_id": "MONDO:0001056" }, { "id": 4264, "label": "jaw cancer", "isLeaf": false, "isRoot": false, "parents": [ 4265, 4587, 20677 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1862", "GARD:0023072", "MEDGEN:155838", "MESH:D007573", "UMLS:C0751255", "icd11.foundation:1535116870" ], "synonyms": [ "jaw neoplasm", "neoplasm of jaw", "cancer of jaw skeleton", "jaw skeleton cancer", "malignant jaw skeleton neoplasm", "malignant neoplasm of jaw skeleton" ], "categories": [ { "ref": "MONDO:0002081", "name": "musculoskeletal system disorder" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A malignant neoplasm involving the jaw skeleton" }, "child_count": 9, "reference_id": "MONDO:0002131" }, { "id": 4735, "label": "liver cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20310, 21432 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3571", "GARD:0027613", "ICD9:155.0", "ICD9:155.2", "MEDGEN:87520", "NCIT:C34803", "SCTID:93870000", "UMLS:C0345904", "icd11.foundation:1605020868" ], "synonyms": [ "cancer of liver", "hepatic cancer", "liver cancer", "malignant liver neoplasm", "malignant neoplasm of liver", "malignant neoplasm of liver, not specified as primary or secondary", "malignant neoplasm of liver, primary", "malignant tumour of liver", "primary liver cancer", "primary malignant liver neoplasm", "primary malignant neoplasm of liver", "primary cancer of liver", "primary tumor of the liver", "primary tumour of the liver" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma." }, "child_count": 15, "reference_id": "MONDO:0002691" }, { "id": 6479, "label": "gastrointestinal lymphoma", "isLeaf": false, "isRoot": false, "parents": [ 4587, 6792 ], "type_id": 0, "properties": { "xrefs": [ "DOID:903", "GARD:0024090", "ICD9:202.80", "MEDGEN:148147", "NCIT:C38162", "SCTID:449072004", "UMLS:C0740372" ], "synonyms": [ "digestive system lymphoma", "gastrointestinal lymphoma", "lymphoma of digestive system", "primary digestive system lymphoma", "primary gastrointestinal lymphoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "A non-Hodgkin or Hodgkin lymphoma that arises from any part of the digestive system, with the bulk of the disease localized to that site." }, "child_count": 20, "reference_id": "MONDO:0004699" }, { "id": 7085, "label": "gallbladder cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20460 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3121", "GARD:0009328", "ICD10CM:C23", "ICD9:156.0", "ICD9:156.8", "MEDGEN:57784", "NCIT:C7481", "ONCOTREE:GBC", "SCTID:363353009", "UMLS:C0153452", "icd11.foundation:922082116" ], "synonyms": [ "gallbladder neoplasm", "tumor of the gallbladder", "tumour of the gallbladder", "cancer of gall bladder", "gall bladder cancer", "malignant gall bladder neoplasm", "malignant gallbladder neoplasm", "malignant gallbladder tumor", "malignant gallbladder tumour", "malignant neoplasm of gall bladder", "malignant neoplasm of gallbladder", "malignant neoplasm of the gallbladder", "malignant tumor of gallbladder", "malignant tumor of the gallbladder", "malignant tumour of gallbladder", "malignant tumour of the gallbladder", "localised malignant gallbladder neoplasm", "localized malignant gallbladder neoplasm" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant neoplasm involving the gall bladder" }, "child_count": 10, "reference_id": "MONDO:0005411" }, { "id": 7170, "label": "oral cavity cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20454 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8618", "EFO:0005570", "ICD9:144", "ICD9:144.0", "ICD9:144.1", "ICD9:145.8", "ICD9:145.9", "ICD9:149.8", "MEDGEN:56298", "NCIT:C9314", "SCTID:363505006", "UMLS:C0153381" ], "synonyms": [ "cancer of oral cavity", "malignant mouth neoplasm", "malignant mouth tumor", "malignant mouth tumour", "malignant neoplasm of mouth", "malignant neoplasm of oral cavity", "malignant neoplasm of the mouth", "malignant oral cavity neoplasm", "malignant oral cavity tumor", "malignant oral cavity tumour", "malignant tumor of anterior floor of mouth", "malignant tumor of lateral floor of mouth", "malignant tumor of mouth", "malignant tumor of oral cavity", "malignant tumor of the mouth", "malignant tumour of anterior floor of mouth", "malignant tumour of lateral floor of mouth", "malignant tumour of mouth", "malignant tumour of oral cavity", "malignant tumour of the mouth", "oral cavity cancer", "malignant neoplasm of anterior portion of floor of mouth", "malignant neoplasm of floor of mouth", "malignant neoplasm of lateral floor of mouth", "malignant neoplasm of lateral portion of floor of mouth", "malignant tumor of the floor of the mouth", "malignant tumour of the floor of the mouth", "mouth cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas." }, "child_count": 22, "reference_id": "MONDO:0005515" }, { "id": 7172, "label": "pharynx cancer", "isLeaf": false, "isRoot": false, "parents": [ 2875, 4587, 20028, 20455, 20492 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0060119", "EFO:0005577", "MEDGEN:57554", "MESH:D010610", "NCIT:C7545", "UMLS:C0153405" ], "synonyms": [ "pharynx neoplasm", "cancer of chordate pharynx", "cancer of pharynx", "chordate pharynx cancer", "malignant chordate pharynx neoplasm", "malignant neoplasm of chordate pharynx", "malignant neoplasm of pharynx", "malignant pharyngeal neoplasm", "malignant pharyngeal tumor", "malignant pharyngeal tumour", "malignant pharynx neoplasm", "malignant pharynx tumor", "malignant pharynx tumour", "malignant tumor of pharynx", "malignant tumor of the pharynx", "malignant tumour of pharynx", "malignant tumour of the pharynx", "pharynx cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005087", "name": "respiratory system disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A primary or metastatic malignant neoplasm that affects the pharynx." }, "child_count": 25, "reference_id": "MONDO:0005517" }, { "id": 7430, "label": "intestinal cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20357 ], "type_id": 0, "properties": { "xrefs": [ "DOID:10155", "EFO:0007330", "ICD9:159.0", "MEDGEN:87562", "MESH:D007414", "NCIT:C4572", "SCTID:363508008", "UMLS:C0346627", "icd11.foundation:150210507" ], "synonyms": [ "bowel cancer", "cancer of intestine", "cancer of the intestine", "intestinal cancer", "intestinal neoplasms, malignant", "intestinal tumors, malignant", "intestine cancer", "malignant intestinal neoplasm", "malignant intestinal neoplasms", "malignant intestinal tumor", "malignant intestinal tumors", "malignant intestinal tumour", "malignant intestinal tumours", "malignant intestine neoplasm", "malignant intestine tumor", "malignant intestine tumour", "malignant neoplasm of intestine", "malignant neoplasm of the intestine", "malignant tumor of intestine", "malignant tumor of the intestine", "malignant tumour of intestine", "malignant tumour of the intestine" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant neoplasm involving the intestine" }, "child_count": 12, "reference_id": "MONDO:0005814" }, { "id": 7558, "label": "spleen cancer", "isLeaf": false, "isRoot": false, "parents": [ 3023, 4587, 22946 ], "type_id": 0, "properties": { "xrefs": [ "DOID:672", "EFO:0007491", "GARD:0024265", "ICD10CM:C26.1", "MEDGEN:102271", "MESH:D013160", "NCIT:C3539", "SCTID:127230005", "UMLS:C0153470", "icd11.foundation:347078862" ], "synonyms": [ "spleen neoplasm", "splenic neoplasm", "cancer of spleen", "cancer of the spleen", "malignant neoplasm of spleen", "malignant neoplasm of the spleen", "malignant spleen neoplasm", "malignant splenic neoplasm", "malignant splenic tumor", "malignant splenic tumour", "malignant tumor of spleen", "malignant tumor of the spleen", "malignant tumour of the spleen", "spleen cancer", "splenic cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "A malignant neoplasm involving the spleen" }, "child_count": 15, "reference_id": "MONDO:0005966" }, { "id": 7738, "label": "digestive system carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4587, 6734 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0050922", "EFO:1000218", "HP:0002672", "MEDGEN:57467", "NCIT:C96963", "UMLS:C0151544" ], "synonyms": [ "carcinoma of digestive system", "carcinoma of the gastrointestinal system", "digestive system carcinoma", "gastrointestinal carcinoma", "gastrointestinal carcinoma (disease)", "gastrointestinal system carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma." }, "child_count": 32, "reference_id": "MONDO:0006181" }, { "id": 8953, "label": "esophageal cancer", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20522 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5041", "GARD:0027778", "ICD10CM:C15", "ICD9:150.3", "ICD9:150.4", "ICD9:150.5", "ICD9:150.8", "ICD9:150.9", "MEDGEN:107792", "NCIT:C7478", "OMIM:133239", "SCTID:363402007", "UMLS:C0546837", "icd11.foundation:669033105" ], "synonyms": [ "cancer of esophagus", "cancer of oesophagus", "esophageal cancer", "esophageal cancer, somatic", "esophageal carcinoma, somatic", "esophageal squamous cell carcinoma, somatic", "esophagus cancer", "malignant esophageal neoplasm", "malignant esophageal tumor", "malignant esophageal tumour", "malignant esophagus neoplasm", "malignant esophagus tumor", "malignant neoplasm of esophagus", "malignant neoplasm of oesophagus", "malignant neoplasm of the esophagus", "malignant neoplasm of the oesophagus", "malignant oesophagus neoplasm", "malignant oesophagus tumour", "malignant tumor of esophagus", "malignant tumor of the esophagus", "malignant tumour of oesophagus", "malignant tumour of the oesophagus", "oesophagus cancer", "Ca lower third esophagus", "Ca lower third oesophagus", "Ca middle third esophagus", "Ca middle third oesophagus", "malignant neoplasm of distal third of esophagus", "malignant neoplasm of distal third of oesophagus", "malignant neoplasm of lower third of esophagus", "malignant neoplasm of lower third of oesophagus", "malignant neoplasm of middle third of esophagus", "malignant neoplasm of middle third of oesophagus", "malignant neoplasm of proximal third of esophagus", "malignant neoplasm of proximal third of oesophagus", "malignant neoplasm of upper third esophagus", "malignant neoplasm of upper third oesophagus", "malignant tumor of abdominal esophagus", "malignant tumor of distal third of esophagus", "malignant tumor of proximal third of esophagus", "malignant tumor of the middle third of the esophagus", "malignant tumour of abdominal oesophagus", "malignant tumour of distal third of oesophagus", "malignant tumour of proximal third of oesophagus", "malignant tumour of the middle third of the oesophagus", "Aerodigestive tract cancer, susceptibility to", "Escc, susceptibility to", "esophageal squamous cell carcinoma, susceptibility to", "gastric cardia adenocarcinoma, susceptibility to" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the esophagus." }, "child_count": 14, "reference_id": "MONDO:0007576" }, { "id": 11035, "label": "malignant pancreatic neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4587, 20285 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1793", "EFO:1000359", "GARD:0027792", "ICD10CM:C25", "ICD9:157.0", "ICD9:157.1", "ICD9:157.2", "ICD9:157.8", "MEDGEN:138068", "NCIT:C9005", "UMLS:C0346647", "icd11.foundation:542147910" ], "synonyms": [ "pancreas neoplasm", "cancer of pancreas", "malignant neoplasm of pancreas", "malignant neoplasm of the pancreas", "malignant pancreas neoplasm", "malignant pancreatic neoplasm", "pancreas cancer", "pancreatic cancer", "pancreatic tumour" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A malignant neoplasm involving the pancreas." }, "child_count": 8, "reference_id": "MONDO:0009831" }, { "id": 20499, "label": "malignant tumor of floor of mouth", "isLeaf": false, "isRoot": false, "parents": [ 4587, 7266, 20540 ], "type_id": 0, "properties": { "xrefs": [ "ICD10CM:C04", "ICD9:144.8", "ICD9:144.9", "MEDGEN:102264", "NCIT:C9318", "SCTID:363385007", "UMLS:C0153368", "icd11.foundation:359540510" ], "synonyms": [ "cancer of mouth floor", "malignant floor of mouth neoplasm", "malignant floor of mouth tumor", "malignant floor of mouth tumour", "malignant floor of the mouth neoplasm", "malignant floor of the mouth tumor", "malignant floor of the mouth tumour", "malignant mouth floor neoplasm", "malignant neoplasm of floor of mouth", "malignant neoplasm of mouth floor", "malignant neoplasm of the floor of the mouth", "malignant tumor of the floor of the mouth", "malignant tumour of the floor of the mouth", "mouth floor cancer" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A cancer that involves the mouth floor." }, "child_count": 3, "reference_id": "MONDO:0021320" }, { "id": 23550, "label": "digestive system melanoma", "isLeaf": false, "isRoot": false, "parents": [ 4587, 7853 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:234305", "NCIT:C7091", "UMLS:C1333798" ], "synonyms": [ "digestive system melanoma", "digestive system melanoma (disease)", "gastrointestinal melanoma", "melanoma (disease) of digestive system" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A melanoma that arises from any part of the digestive system." }, "child_count": 6, "reference_id": "MONDO:0045070" }, { "id": 25157, "label": "gastroesophageal cancer", "isLeaf": true, "isRoot": false, "parents": [ 4587 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080374", "MEDGEN:577508", "UMLS:C0346619" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A gastrointestinal system cancer that is located in the proximal esophagus and the distal stomach." }, "child_count": 0, "reference_id": "MONDO:0850129" } ], "roots": [ { "id": 6151, "label": "digestive system disorder" }, { "id": 6733, "label": "cancer" }, { "id": 20434, "label": "digestive system neoplasm" } ] }