{
  "id": 4592,
  "label": "tenosynovial giant cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002522",
  "properties": {
    "xrefs": [
      "DOID:314",
      "EFO:1000562",
      "ICD9:727.89",
      "ICDO:9252/0",
      "MEDGEN:232927",
      "NCIT:C3402",
      "SCTID:310605004",
      "UMLS:C1318543"
    ],
    "synonyms": [
      "fibrous histiocytoma of tendon sheath",
      "giant cell neoplasm of Tenosynovium",
      "giant cell neoplasm of tendon sheath",
      "giant cell neoplasm of the Tenosynovium",
      "giant cell tumor of Tenosynovium",
      "giant cell tumor of tendon sheath",
      "giant cell tumor of the Tenosynovium",
      "giant cell tumour of the Tenosynovium",
      "tendon sheath giant cell neoplasm",
      "tendon sheath giant cell tumor",
      "tendon sheath giant cell tumour",
      "tenosynovial giant cell neoplasm",
      "tenosynovial giant cell tumor"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4297,
      "label": "giant cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:200",
          "MEDGEN:6598",
          "MESH:D005870",
          "NCIT:C3055",
          "SCTID:443790001",
          "UMLS:C0017525"
        ],
        "synonyms": [
          "giant cell neoplasm",
          "giant cell tumor",
          "giant cell tumor (morphologic abnormality)",
          "giant cell tumor (qualifier value)",
          "giant cell tumor NOS (morphologic abnormality)",
          "giant cell tumors (morphologic abnormality)",
          "giant cell tumour (morphologic abnormality)",
          "giant cell tumour (qualifier value)",
          "giant cell tumour NOS (morphologic abnormality)",
          "giant cell tumours (morphologic abnormality)",
          "tumor of the giant cell",
          "tumour of the giant cell",
          "giant cell tumors",
          "giant cell tumours"
        ],
        "definition": "A benign, intermediate, or malignant tumor that arises from the bone or soft tissue. It is characterized by the presence of multinucleated osteoclast-like giant cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002171"
    },
    {
      "id": 4597,
      "label": "synovium neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7941,
        8264,
        23662
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:315",
          "MEDGEN:99197",
          "NCIT:C8964",
          "UMLS:C0476203"
        ],
        "synonyms": [
          "neoplasm of synovial membrane of synovial joint",
          "neoplasm of synovium",
          "neoplasm of the synovium",
          "synovial membrane of synovial joint neoplasm",
          "synovial membrane of synovial joint neoplasm (disease)",
          "synovial membrane of synovial joint tumor",
          "synovial membrane of synovial joint tumour",
          "synovial neoplasm",
          "synovial neoplasm (morphologic abnormality)",
          "synovial neoplasm NOS (morphologic abnormality)",
          "synovial tumor",
          "synovial tumour",
          "tumor of synovial membrane of synovial joint",
          "tumor of synovium",
          "tumor of the synovium",
          "tumour of synovial membrane of synovial joint",
          "tumour of synovium",
          "tumour of the synovium"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A benign or malignant soft tissue neoplasm arising exclusively from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath, localized giant cell tumor of tendon sheath, and malignant giant cell tumor of tendon sheath."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002528"
    },
    {
      "id": 20678,
      "label": "connective tissue neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762,
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.2",
          "MEDGEN:45035",
          "MESH:D009372",
          "SCTID:126598008",
          "UMLS:C0027656"
        ],
        "synonyms": [
          "connective tissue neoplasm",
          "connective tissue neoplasm (disease)",
          "connective tissue tumor",
          "connective tissue tumour",
          "neoplasm of connective tissue",
          "neoplasm of connective tissues",
          "tumor of connective tissue",
          "tumour of connective tissue",
          "connective tissue neoplasms",
          "neoplasm, connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021581"
    },
    {
      "id": 21600,
      "label": "tendon sheath disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:727.9",
          "MEDGEN:675994",
          "SCTID:312381009",
          "UMLS:C0729734"
        ],
        "synonyms": [
          "disease of tendon sheath",
          "disease or disorder of tendon sheath",
          "disorder of tendon sheath",
          "tendon sheath disease",
          "tendon sheath disease or disorder",
          "tendon sheath disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A disease that involves the tendon sheath."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024876"
    }
  ],
  "children": [
    {
      "id": 4489,
      "label": "tenosynovial giant cell tumor, localized type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4592,
        21582
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2701",
          "ICD9:727.02",
          "MEDGEN:154413",
          "NCIT:C6532",
          "SCTID:95413004",
          "UMLS:C0588125"
        ],
        "synonyms": [
          "localised giant cell neoplasm of Tenosynovium",
          "localised giant cell neoplasm of tendon sheath",
          "localised giant cell neoplasm of the Tenosynovium",
          "localised giant cell tumour of Tenosynovium",
          "localised giant cell tumour of tendon sheath",
          "localised giant cell tumour of the Tenosynovium",
          "localised tenosynovial giant cell neoplasm",
          "localised tenosynovial giant cell tumour",
          "localized giant cell neoplasm of Tenosynovium",
          "localized giant cell neoplasm of tendon sheath",
          "localized giant cell neoplasm of the Tenosynovium",
          "localized giant cell tumor of Tenosynovium",
          "localized giant cell tumor of tendon sheath",
          "localized giant cell tumor of the Tenosynovium",
          "localized tenosynovial giant cell neoplasm",
          "localized tenosynovial giant cell tumor",
          "nodular tenosynovitis",
          "synovioma, benign (morphologic abnormality)",
          "tenosynovial giant cell tumor, localized type",
          "benign synovioma",
          "benign tumor of synovium",
          "benign tumour of synovium"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A well-circumscribed, lobulated tumor, completely or partially covered by a fibrous capsule. It usually arises in the fingers. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. The tumor is slow-growing, usually developing over several years. Clinical presentation includes painless edema of the affected site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002399"
    },
    {
      "id": 4491,
      "label": "malignant tenosynovial giant cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4492,
        4493,
        4592
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2704",
          "GARD:0027606",
          "ICDO:9252/3",
          "MEDGEN:226849",
          "NCIT:C6535",
          "UMLS:C1266168"
        ],
        "synonyms": [
          "giant cell tumor of tendon sheath, malignant",
          "malignant giant cell neoplasm of tendon sheath",
          "malignant giant cell neoplasm of the tendon sheath",
          "malignant giant cell tumor of tendon sheath",
          "malignant giant cell tumor of the tendon sheath",
          "malignant giant cell tumour of tendon sheath",
          "malignant giant cell tumour of the tendon sheath",
          "malignant tendon sheath giant cell neoplasm",
          "malignant tendon sheath giant cell tumor",
          "malignant tendon sheath giant cell tumour",
          "malignant tenosynovial giant cell tumor",
          "tenosynovial giant cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An uncommon malignant tumor arising from the tendon sheath. Morphologically, it is characterized by the presence of a cellular infiltrate reminiscent of a giant cell tumor with prominent malignant characteristics. Recurrent giant cell tumors with a sarcomatous dedifferentiation are included in this category as well."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002401"
    },
    {
      "id": 21580,
      "label": "tenosynovial giant cell tumor, diffuse type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4592,
        21582
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2702",
          "DOID:9898",
          "GARD:0007396",
          "ICD10CM:M12.2",
          "ICD9:719.2",
          "ICD9:719.20",
          "ICD9:719.28",
          "ICDO:9251/0",
          "MEDGEN:11691",
          "MESH:D013586",
          "NCIT:C3401",
          "NORD:1916",
          "ONCOTREE:TGCT",
          "Orphanet:66627",
          "SCTID:95412009",
          "UMLS:C0039106"
        ],
        "synonyms": [
          "TGCT",
          "TSGCT",
          "Tenosynovial Giant Cell Tumor",
          "diffuse giant cell neoplasm of Tenosynovium",
          "diffuse giant cell neoplasm of tendon sheath",
          "diffuse giant cell neoplasm of the Tenosynovium",
          "diffuse giant cell tumor of Tenosynovium",
          "diffuse giant cell tumor of tendon sheath",
          "diffuse giant cell tumor of the Tenosynovium",
          "diffuse giant cell tumour of Tenosynovium",
          "diffuse giant cell tumour of tendon sheath",
          "diffuse giant cell tumour of the Tenosynovium",
          "diffuse tenosynovial giant cell neoplasm",
          "diffuse tenosynovial giant cell tumor",
          "diffuse tenosynovial giant cell tumour",
          "pigmented villonodular synovitis",
          "tenosynovial giant cell tumor, diffuse type",
          "diffuse pigmented villonodular synovitis",
          "diffuse-type GCT",
          "diffuse-type giant cell tumor",
          "diffuse-type giant cell tumour",
          "localised pigmented villonodular synovitis",
          "localized pigmented villonodular synovitis",
          "tenosynovial giant cell tumor",
          "tenosynovial giant cell tumor diffuse type",
          "tenosynovial giant cell tumors",
          "tenosynovial giant cell tumour",
          "tenosynovial giant cell tumour diffuse type",
          "tenosynovial giant cell tumours",
          "villonodular synovitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024686"
    }
  ],
  "roots": [
    {
      "id": 4297,
      "label": "giant cell tumor"
    },
    {
      "id": 4597,
      "label": "synovium neoplasm"
    },
    {
      "id": 20678,
      "label": "connective tissue neoplasm"
    },
    {
      "id": 21600,
      "label": "tendon sheath disorder"
    }
  ]
}