{
  "id": 4612,
  "label": "schwannoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002546",
  "properties": {
    "xrefs": [
      "DOID:3192",
      "DOID:955",
      "EFO:0000693",
      "GARD:0004767",
      "ICD9:215.9",
      "ICDO:9560/0",
      "MEDGEN:45053",
      "MedDRA:10029234",
      "MedDRA:10029235",
      "NANDO:2200103",
      "NCIT:C3269",
      "ONCOTREE:SCHW",
      "Orphanet:252164",
      "SCTID:404022001",
      "UMLS:C0027809",
      "icd11.foundation:378766741"
    ],
    "synonyms": [
      "benign neurilemmoma",
      "benign schwannoma",
      "neurilemmoma",
      "neurinoma",
      "peripheral fibroblastoma",
      "schwannoma",
      "schwannoma (WHO grade I)",
      "schwannoma, benign",
      "SCHW",
      "neurolemmoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3627,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3193",
          "GARD:0023161",
          "MEDGEN:64639",
          "MESH:D018317",
          "NCIT:C4972",
          "ONCOTREE:NST",
          "UMLS:C0206727"
        ],
        "synonyms": [
          "neoplasm of nerve sheath",
          "neoplasm of the nerve sheath",
          "nerve sheath neoplasm",
          "nerve sheath tumor",
          "tumor of nerve sheath",
          "tumour of nerve sheath"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002547"
    },
    {
      "id": 17200,
      "label": "benign peripheral nerve sheath tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17197
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007180",
          "MEDGEN:1843306",
          "Orphanet:252131",
          "UMLS:C5577926"
        ],
        "synonyms": [
          "BPNST"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0016752"
    },
    {
      "id": 20693,
      "label": "low grade glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060101",
          "DOID:0080829",
          "GARD:0025343",
          "MEDGEN:744283",
          "NCIT:C132067",
          "UMLS:C1997217"
        ],
        "synonyms": [
          "benign glioma",
          "glioma, benign",
          "low grade glioma",
          "low-grade glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021637"
    }
  ],
  "children": [
    {
      "id": 3774,
      "label": "acoustic neuroma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2012-6947",
          "DOID:12689",
          "GARD:0000223",
          "HP:0009588",
          "MEDGEN:45062",
          "MESH:D009464",
          "MedDRA:10000523",
          "NCIT:C3276",
          "NORD:715",
          "Orphanet:252175",
          "SCTID:126949007",
          "UMLS:C0027859",
          "icd11.foundation:480288993"
        ],
        "synonyms": [
          "acoustic tumor",
          "acoustic tumour",
          "acoustic neurilemmoma",
          "acoustic neurilemoma",
          "acoustic neurinoma",
          "acoustic neuroma",
          "acoustic schwannoma",
          "neurilemoma, acoustic",
          "neurinoma of the acoustic nerve",
          "neuroma, acoustic",
          "vestibular neurilemmoma",
          "vestibular schwannoma",
          "vestibular schwannoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A type of benign brain tumor that begins in the Schwann cells, which produce the myelin that protects the acoustic nerve - the nerve of hearing."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001569"
    },
    {
      "id": 4614,
      "label": "cellular schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3196",
          "GARD:0023162",
          "ICD9:215.9",
          "MEDGEN:98124",
          "NCIT:C4724",
          "ONCOTREE:CSCHW",
          "SCTID:404026003",
          "UMLS:C0431124"
        ],
        "synonyms": [
          "cellular neurilemmoma",
          "cellular neurinoma",
          "cellular schwannoma",
          "CSCHW"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A morphologic variant of schwannoma characterized by hypercellularity, Antoni A pattern, and the absence of well-formed Verocay bodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002548"
    },
    {
      "id": 4615,
      "label": "schwannoma of twelfth cranial nerve",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4612,
        4616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3197",
          "GARD:0023163",
          "MEDGEN:235581",
          "NCIT:C5434",
          "UMLS:C1335928"
        ],
        "synonyms": [
          "hypoglossal nerve neurilemmoma",
          "hypoglossal nerve schwannoma",
          "hypoglossal neurilemmoma",
          "hypoglossal schwannoma",
          "neurilemmoma of hypoglossal nerve",
          "neurilemmoma of the hypoglossal nerve",
          "neurilemmoma of the twelfth cranial nerve",
          "neurilemmoma of twelfth cranial nerve",
          "schwannoma of hypoglossal nerve",
          "schwannoma of the hypoglossal nerve",
          "schwannoma of the twelfth cranial nerve",
          "schwannoma of twelfth cranial nerve",
          "twelfth cranial nerve neurilemmoma",
          "twelfth cranial nerve schwannoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schwannoma that involves the hypoglossal nerve."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002549"
    },
    {
      "id": 4620,
      "label": "sympathetic neurilemmoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4464,
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3201",
          "GARD:0023164",
          "MEDGEN:236964",
          "NCIT:C5421",
          "UMLS:C1336543"
        ],
        "synonyms": [
          "sympathetic schwannoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign tumor derived from schwann cells of the peripheral sympathetic nervous system, including the sympathetic plexus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002554"
    },
    {
      "id": 4621,
      "label": "trigeminal schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3641,
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3202",
          "GARD:0023165",
          "ICD9:215.9",
          "MEDGEN:83890",
          "NCIT:C4655",
          "SCTID:277185000",
          "UMLS:C0349582"
        ],
        "synonyms": [
          "fifth cranial nerve neurilemmoma",
          "fifth cranial nerve schwannoma",
          "neurilemmoma of fifth cranial nerve",
          "neurilemmoma of the fifth cranial nerve",
          "neurilemmoma of the trigeminal nerve",
          "neurilemmoma of trigeminal nerve",
          "schwannoma of fifth cranial nerve",
          "schwannoma of the fifth cranial nerve",
          "schwannoma of the trigeminal nerve",
          "schwannoma of trigeminal nerve",
          "trigeminal nerve schwannoma",
          "trigeminal neurilemmoma",
          "trigeminal schwannoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schwannoma that involves the trigeminal nerve."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002555"
    },
    {
      "id": 4622,
      "label": "microcystic/reticular schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023166",
          "MEDGEN:882329",
          "NCIT:C5321",
          "UMLS:C4054526"
        ],
        "synonyms": [
          "microcystic/reticular schwannoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The rarest histopathologic subtype of Schwannoma. The reported cases have been located in the gastrointestinal submucosa or subcutaneous tissue. Morphologically it is characterized by the presence of a microcyst-rich network of spindle cells with minimal amount of cytoplasm and Antoni A tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002556"
    },
    {
      "id": 4623,
      "label": "melanotic neurilemmoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3205",
          "GARD:0023167",
          "ICD9:215.8",
          "MEDGEN:266292",
          "NCIT:C6970",
          "ONCOTREE:MSCHW",
          "SCTID:404024000",
          "UMLS:C1306247"
        ],
        "synonyms": [
          "melanocytic neurilemmoma",
          "melanocytic schwannoma",
          "melanotic neurinoma",
          "melanotic schwannoma",
          "melanotic schwannoma (morphologic abnormality)",
          "pigmented neurilemmoma",
          "pigmented schwannoma",
          "MSCHW"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. It is composed of cells with the immunophenotypic and electron microscopic features of Schwann cells which contain melanosomes and are positive for melanoma markers. It usually involves spinal nerve roots but may occur in other locations. It may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior has been reported in a significant number of patients."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002558"
    },
    {
      "id": 4624,
      "label": "plexiform schwannoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3206",
          "GARD:0023168",
          "ICD9:215.9",
          "MEDGEN:277972",
          "NCIT:C6969",
          "SCTID:404025004",
          "UMLS:C1370659"
        ],
        "synonyms": [
          "plexiform neurilemmoma",
          "plexiform neurinoma",
          "plexiform schwannoma",
          "plexiform schwannoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schwannoma characterized by a plexiform or multinodular growth pattern. It usually arises from the skin or subcutaneous tissues in the extremities, trunk, and head and neck."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002559"
    },
    {
      "id": 6580,
      "label": "peripheral nerve schwannoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4612
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:956",
          "GARD:0024115",
          "MEDGEN:274155",
          "NCIT:C41430",
          "UMLS:C1519001"
        ],
        "synonyms": [
          "peripheral nerve schwannoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign, usually encapsulated slow growing tumor of the peripheral nervous system composed of Schwann cells. It recurs infrequently and only rare cases associated with malignant transformation have been reported."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004820"
    },
    {
      "id": 9396,
      "label": "schwannomatosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4599,
        4612,
        19140,
        19507,
        20303,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3204",
          "GARD:0004768",
          "ICD10CM:Q85.03",
          "ICD9:237.73",
          "ICDO:9560/1",
          "MEDGEN:234775",
          "NCIT:C6557",
          "OMIMPS:162091",
          "Orphanet:93921",
          "UMLS:C1335929"
        ],
        "synonyms": [
          "NF3",
          "Neurinomatosis",
          "Schwannomatosis",
          "neurilemmomatosis",
          "neurofibromatosis type 3",
          "schwannomatosis",
          "schwannomatosis, NEC",
          "schwannomatosis, NOS",
          "congenital cutaneous neurilemmomatosis",
          "neurilemmomatosis congenital cutaneous",
          "neurilemmomatosis, congenital cutaneous",
          "neurinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The least frequent form of the rare genetic disorder neurofibromatosis. It is clinically and genetically distinct from NF1 and NF2 and is characterized by the development of multiple schwannomas (nerve sheath tumors), without involvement of the vestibular nerves. NF3 develops in adulthood and is often associated with chronic pain. Dysesthesia and paresthesia may also be present. Common localizations include the spine, peripheral nerves, and the cranium."
      },
      "child_count": 24,
      "reference_id": "MONDO:0008075"
    }
  ],
  "roots": [
    {
      "id": 4613,
      "label": "nerve sheath neoplasm"
    },
    {
      "id": 17200,
      "label": "benign peripheral nerve sheath tumor"
    },
    {
      "id": 20693,
      "label": "low grade glioma"
    }
  ]
}