{
  "id": 4613,
  "label": "nerve sheath neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002547",
  "properties": {
    "xrefs": [
      "DOID:3193",
      "GARD:0023161",
      "MEDGEN:64639",
      "MESH:D018317",
      "NCIT:C4972",
      "ONCOTREE:NST",
      "UMLS:C0206727"
    ],
    "synonyms": [
      "neoplasm of nerve sheath",
      "neoplasm of the nerve sheath",
      "nerve sheath neoplasm",
      "nerve sheath tumor",
      "tumor of nerve sheath",
      "tumour of nerve sheath"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 3627,
      "label": "peripheral nervous system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5512,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1192",
          "EFO:0002431",
          "ICD9:239.2",
          "MEDGEN:45817",
          "MESH:D010524",
          "NCIT:C3321",
          "ONCOTREE:PNS",
          "SCTID:126980002",
          "UMLS:C0031118"
        ],
        "synonyms": [
          "PNS neoplasm",
          "PNS neoplasms",
          "PNS tumor",
          "PNS tumour",
          "neoplasm of PNS",
          "neoplasm of peripheral nerve",
          "neoplasm of peripheral nervous system",
          "neoplasm of the PNS",
          "neoplasm of the peripheral nerve",
          "neoplasm of the peripheral nervous system",
          "neoplasms, PNS",
          "neoplasms, peripheral nervous system",
          "peripheral nerve neoplasm",
          "peripheral nerve tumor",
          "peripheral nerve tumour",
          "peripheral nervous system neoplasm",
          "peripheral nervous system neoplasm (disease)",
          "peripheral nervous system tumor",
          "peripheral nervous system tumour",
          "tumor of PNS",
          "tumor of peripheral nerve",
          "tumor of peripheral nervous system",
          "tumor of the PNS",
          "tumor of the peripheral nerve",
          "tumor of the peripheral nervous system",
          "tumour of PNS",
          "tumour of peripheral nerve",
          "tumour of peripheral nervous system",
          "tumour of the PNS",
          "tumour of the peripheral nerve",
          "tumour of the peripheral nervous system",
          "CNS-excluded nervous sys. cancer",
          "nerve sheath neoplasm",
          "nerve sheath tumors",
          "nerve sheath tumours"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001406"
    },
    {
      "id": 20287,
      "label": "glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20418
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005543",
          "GARD:0006513",
          "MEDGEN:9030",
          "MESH:D005910",
          "NCIT:C3059",
          "Orphanet:182067",
          "SCTID:393564001",
          "UMLS:C0017638"
        ],
        "synonyms": [
          "glial neoplasm",
          "glial tumor",
          "glial tumour",
          "glioma",
          "neoplasm of neuroglia",
          "neoplasm of the neuroglia",
          "neuroglial neoplasm",
          "neuroglial tumor",
          "neuroglial tumour",
          "tumor of neuroglia",
          "tumor of the neuroglia",
          "tumour of neuroglia",
          "tumour of the neuroglia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0021042"
    }
  ],
  "children": [
    {
      "id": 4612,
      "label": "schwannoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613,
        17200,
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3192",
          "DOID:955",
          "EFO:0000693",
          "GARD:0004767",
          "ICD9:215.9",
          "ICDO:9560/0",
          "MEDGEN:45053",
          "MedDRA:10029234",
          "MedDRA:10029235",
          "NANDO:2200103",
          "NCIT:C3269",
          "ONCOTREE:SCHW",
          "Orphanet:252164",
          "SCTID:404022001",
          "UMLS:C0027809",
          "icd11.foundation:378766741"
        ],
        "synonyms": [
          "benign neurilemmoma",
          "benign schwannoma",
          "neurilemmoma",
          "neurinoma",
          "peripheral fibroblastoma",
          "schwannoma",
          "schwannoma (WHO grade I)",
          "schwannoma, benign",
          "SCHW",
          "neurolemmoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported."
      },
      "child_count": 30,
      "reference_id": "MONDO:0002546"
    },
    {
      "id": 7788,
      "label": "granular cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2411",
          "EFO:1000284",
          "GARD:0009618",
          "ICD9:215.9",
          "ICDO:9580/0",
          "MEDGEN:88345",
          "MESH:C535558",
          "MESH:D016586",
          "NCIT:C3474",
          "ONCOTREE:GCT",
          "SCTID:404035005",
          "UMLS:C0085167"
        ],
        "synonyms": [
          "Abrikossoff tumor",
          "Abrikossoff tumour",
          "Abrikossoff's tumor",
          "Abrikossoff's tumour",
          "granular cell myoblastoma",
          "granular cell neoplasm",
          "granular cell nerve sheath tumor",
          "granular cell nerve sheath tumour",
          "granular cell schwannoma",
          "granular cell tumor",
          "granular cell tumor (morphologic abnormality)",
          "granular cell tumour (morphologic abnormality)",
          "granular cell tumor NOS (morphologic abnormality)",
          "granular cell tumour NOS (morphologic abnormality)",
          "neoplasm of granular cell",
          "Abrikosoff's granulous cell tumor",
          "Abrikosoff's granulous cell tumour",
          "Abrikosoff's tumor",
          "Abrikosoff's tumour",
          "Abrikosov's tumor",
          "Abrikosov's tumour",
          "Abrikosov’s tumor",
          "Abrikosov’s tumour",
          "GCT",
          "giant granulocellular Abrikosov's tumor",
          "giant granulocellular Abrikosov's tumour",
          "malignant variant of Abrikosov's tumor",
          "malignant variant of Abrikosov's tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006235"
    },
    {
      "id": 7852,
      "label": "neurothekeoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000394",
          "GARD:0024369",
          "ICDO:9562/0",
          "MEDGEN:64641",
          "MESH:D018321",
          "NCIT:C7018",
          "UMLS:C0206730"
        ],
        "synonyms": [
          "nerve sheath Myxoma",
          "neurothekeoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign neoplasm arising from nerve sheaths. It is characterized by the presence of a myxoid stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006317"
    },
    {
      "id": 17201,
      "label": "neurofibroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613,
        17200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:962",
          "GARD:0007191",
          "ICD9:215.9",
          "ICDO:9540/0",
          "MEDGEN:45058",
          "MESH:D009455",
          "MedDRA:10029267",
          "NCIT:C3272",
          "ONCOTREE:NFIB",
          "Orphanet:252183",
          "SCTID:404029005",
          "UMLS:C0027830",
          "icd11.foundation:221014277"
        ],
        "synonyms": [
          "neurofibroma",
          "neurofibroma (WHO grade I)",
          "neurofibroma, benign",
          "NFIB"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Patients with neurofibromatosis type 1 present with multiple masses. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors."
      },
      "child_count": 22,
      "reference_id": "MONDO:0016755"
    },
    {
      "id": 18046,
      "label": "malignant peripheral nerve sheath tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4336,
        4613,
        17197,
        20329,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5940",
          "EFO:0000760",
          "GARD:0010872",
          "ICD9:171.9",
          "ICDO:9540/3",
          "ICDO:9560/3",
          "MEDGEN:155614",
          "MedDRA:10029236",
          "NANDO:2200102",
          "NCIT:C3798",
          "ONCOTREE:MPNST",
          "Orphanet:3148",
          "SCTID:404037002",
          "UMLS:C0751690",
          "icd11.foundation:71413945"
        ],
        "synonyms": [
          "neurofibrosarcoma",
          "MPNST",
          "Malig. periph. nerve sheath tum.",
          "malignant neoplasm of peripheral nerve sheath",
          "malignant neurilemmoma",
          "malignant neurilemoma",
          "malignant neurofibroma",
          "malignant peripheral nerve sheath neoplasm",
          "malignant peripheral nerve sheath tumor",
          "malignant peripheral nerve sheath tumor (morphologic abnormality)",
          "malignant peripheral nerve sheath tumor [dup] (morphologic abnormality)",
          "malignant peripheral nerve sheath tumour (morphologic abnormality)",
          "malignant peripheral nerve sheath tumour [dup] (morphologic abnormality)",
          "malignant schwannoma",
          "malignant tumor of peripheral nerve sheath",
          "malignant tumor of the peripheral nerve sheath",
          "malignant tumour of peripheral nerve sheath",
          "malignant tumour of the peripheral nerve sheath",
          "neurofibrosarcoma, malignant",
          "neurogenic sarcoma",
          "schwannoma, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant peripheral nerve sheath tumor (MPNST) is a rare and often aggressive soft tissue sarcoma occurring in a wide range of anatomical sites."
      },
      "child_count": 35,
      "reference_id": "MONDO:0017827"
    },
    {
      "id": 19233,
      "label": "perineurioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4613,
        17197
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4697",
          "GARD:0012698",
          "ICD9:215.9",
          "ICDO:9571/0",
          "MEDGEN:199712",
          "NCIT:C4973",
          "Orphanet:85102",
          "SCTID:404036006",
          "UMLS:C0751691",
          "icd11.foundation:456459236"
        ],
        "synonyms": [
          "perineurioma",
          "soft tissue perineurioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A usually benign perineurioma not associated with a nerve, arising from the soft tissues."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019404"
    }
  ],
  "roots": [
    {
      "id": 3627,
      "label": "peripheral nervous system neoplasm"
    },
    {
      "id": 20287,
      "label": "glioma"
    }
  ]
}