{
  "id": 4626,
  "label": "demyelinating disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002562",
  "properties": {
    "xrefs": [
      "DOID:3213",
      "MEDGEN:4189",
      "MESH:D003711",
      "NCIT:C34527",
      "UMLS:C0011303"
    ],
    "synonyms": [
      "demyelinating disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase traveling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 7208,
      "label": "neurodegenerative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1289",
          "EFO:0005772",
          "ICD9:349.89",
          "MEDGEN:17999",
          "MESH:D019636",
          "NCIT:C4802",
          "SCTID:80690008",
          "UMLS:C0027746"
        ],
        "synonyms": [
          "degenerative disease",
          "brain degeneration",
          "central nervous system degenerative disorder",
          "central nervous system neurodegenerative disorder",
          "degenerative disorder of central nervous system",
          "cerebral degeneration disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005559"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 5272,
      "label": "demyelinating polyneuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4005,
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5214",
          "GARD:0023456",
          "ICD9:356.9",
          "MEDGEN:82859",
          "NCIT:C27062",
          "SCTID:23414001",
          "UMLS:C0270922"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Polyneuropathy that is characterized by demyelination of axons."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003334"
    },
    {
      "id": 8157,
      "label": "central pontine myelinolysis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:636",
          "EFO:1000857",
          "ICD10CM:G37.2",
          "ICD9:341.8",
          "MEDGEN:64511",
          "MESH:D017590",
          "MedDRA:10007968",
          "NCIT:C84623",
          "SCTID:6807001",
          "UMLS:C0206083",
          "icd11.foundation:558060012"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A central nervous system disorder caused by demyelination within the central basis pontis of the brain. It is characterized by spastic quadriplegia, pseudobulbar palsy and encephalopathy. It is observed in patients with severe hyponatremia, particularly when the hyponatremia is corrected too rapidly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006692"
    },
    {
      "id": 8348,
      "label": "polyradiculoneuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4005,
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4308",
          "EFO:1001116",
          "GARD:0024500",
          "MEDGEN:46012",
          "MESH:D011129",
          "SCTID:128078004",
          "UMLS:C0032587"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (guillain-barre syndrome) and polyradiculoneuropathy, chronic inflammatory demyelinating. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006915"
    },
    {
      "id": 11273,
      "label": "Schilder disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016661",
          "ICD10CM:G37.0",
          "ICD9:341.1",
          "MEDGEN:3324",
          "OMIM:272100",
          "Orphanet:59298",
          "SCTID:49692006",
          "UMLS:C0007795"
        ],
        "synonyms": [
          "Schilder disease",
          "Schilder's disease",
          "myelinoclastic diffuse sclerosis",
          "sudanophillic cerebral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Schilder's disease is a progressive demyelinating disorder of the central nervous system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010085"
    },
    {
      "id": 16944,
      "label": "Balo concentric sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060215",
          "GARD:0005885",
          "MEDGEN:498",
          "MedDRA:10010252",
          "NANDO:1200028",
          "NORD:835",
          "Orphanet:228165",
          "SCTID:230380005",
          "UMLS:C0004712"
        ],
        "synonyms": [
          "Balo Disease",
          "Balo concentric sclerosis",
          "Balo's concentric sclerosis",
          "concentric demyelination",
          "Balo disease",
          "Balo's disease",
          "Baló concentric sclerosis",
          "Marburg variant",
          "Tumefactive multiple sclerosis",
          "diffuse cerebral sclerosis of Schilder",
          "encephalitis periaxialis concentrica"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Tumefactive multiple sclerosis is characterized by a tumor-like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor. It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures, and weakness. The cause of tumefactive MS is not known. It often develops into the relapsing-remitting form of MS. In other cases there is only one occurrence of the condition. In still others the disease process remains less clear. While there is no cure for tumefactive MS, treatments such as corticosteroids are available to decrease disease activity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016430"
    },
    {
      "id": 19214,
      "label": "acute disseminated encephalomyelitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4626,
        19722
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:639",
          "EFO:0007130",
          "GARD:0008639",
          "ICD9:136.9",
          "MEDGEN:4033",
          "MESH:D004673",
          "NCIT:C34578",
          "NORD:727",
          "Orphanet:83597",
          "SCTID:83942000",
          "UMLS:C0014059",
          "icd11.foundation:1390433308"
        ],
        "synonyms": [
          "ADEM",
          "acute disseminated encephalitis",
          "acute disseminated encephalomyelitis",
          "post-infectious encephalomyelitis",
          "ADE"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute disseminated encephalomyelitis (ADEM) is a demyelinating disorder of the central nervous system."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019383"
    },
    {
      "id": 20199,
      "label": "demyelinating disease of central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:G35-G37",
          "ICD9:341.8",
          "ICD9:341.9",
          "MEDGEN:3719",
          "NCIT:C34526",
          "SCTID:6118003",
          "UMLS:C0011302"
        ],
        "synonyms": [
          "demyelinating CNS disease",
          "demyelinating disease central nervous system (CNS)",
          "demyelinating disease of central nervous system",
          "demyelinating disorder of central nervous system",
          "demyelinating disorders of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any condition in which there is degeneration of the myelin sheath that covers the nerves of the central nervous system."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020800"
    },
    {
      "id": 20806,
      "label": "boylan dew greco syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4626,
        10051,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000954",
          "MEDGEN:419407",
          "MESH:C537083",
          "UMLS:C2931419"
        ],
        "synonyms": [
          "congenital hypomyelination neuropathy with arthrogryposis multiplex congenita"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0022025"
    }
  ],
  "roots": [
    {
      "id": 7208,
      "label": "neurodegenerative disease"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}