{
  "id": 4634,
  "label": "primary central nervous system lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002571",
  "properties": {
    "xrefs": [
      "DOID:3234",
      "EFO:1000157",
      "GARD:0009318",
      "ICD9:200.5",
      "MEDGEN:79187",
      "MedDRA:10036685",
      "NCIT:C9301",
      "NORD:2002",
      "ONCOTREE:PCNSL",
      "Orphanet:46135",
      "SCTID:307649006",
      "UMLS:C0280803",
      "icd11.foundation:1133193893"
    ],
    "synonyms": [
      "CNS lymphoma",
      "PCNSL",
      "central nervous system lymphoma",
      "lymphoma of central nervous system",
      "malignant lymphomas of CNS",
      "malignant lymphomas of the CNS",
      "microglioma",
      "primary CNS lymphoma",
      "primary brain lymphoma",
      "primary central nervous system lymphoma",
      "primary lymphoma, CNS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3028,
      "label": "immune system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060083"
        ],
        "synonyms": [
          "cancer of immune system",
          "immune system cancer",
          "malignant immune system neoplasm",
          "malignant neoplasm of immune system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the immune system"
      },
      "child_count": 50,
      "reference_id": "MONDO:0000621"
    },
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 5530,
      "label": "central nervous system hematopoietic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7694,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5772",
          "GARD:0023597",
          "MEDGEN:234101",
          "NCIT:C5503",
          "UMLS:C1332882"
        ],
        "synonyms": [
          "CNS haematopoietic neoplasm",
          "CNS haematopoietic tumour",
          "CNS hematopoietic neoplasm",
          "CNS hematopoietic tumor",
          "central nervous system haematopoietic and lymphoid system neoplasm",
          "central nervous system haematopoietic neoplasms",
          "central nervous system haematopoietic tumour",
          "central nervous system hematopoietic and lymphoid system neoplasm",
          "central nervous system hematopoietic neoplasm",
          "central nervous system hematopoietic neoplasms",
          "central nervous system hematopoietic tumor",
          "haematopoietic and lymphoid system neoplasm of central nervous system",
          "haematopoietic neoplasm of CNS",
          "haematopoietic neoplasm of central nervous system",
          "haematopoietic neoplasm of the CNS",
          "haematopoietic neoplasm of the central nervous system",
          "haematopoietic tumour of central nervous system",
          "haematopoietic tumour of the central nervous system",
          "hematopoietic and lymphoid system neoplasm of central nervous system",
          "hematopoietic neoplasm of CNS",
          "hematopoietic neoplasm of central nervous system",
          "hematopoietic neoplasm of the CNS",
          "hematopoietic neoplasm of the central nervous system",
          "hematopoietic tumor of central nervous system",
          "hematopoietic tumor of the central nervous system",
          "lymphomas and hemopoietic neoplasms of CNS",
          "lymphomas and hemopoietic neoplasms of the CNS",
          "central nervous system hematologic cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A primary or metastatic neoplasm of hematopoietic origin that affects the brain, meninges, or spinal cord. Representative examples include Hodgkin and non-Hodgkin lymphomas, histiocytic tumors, and leukemias."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003641"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:706",
          "EFO:0000096",
          "GARD:0024136",
          "ICD9:202.0",
          "MEDGEN:235305",
          "NCIT:C27910",
          "ONCOTREE:MBN",
          "SCTID:269476000",
          "UMLS:C1334633"
        ],
        "synonyms": [
          "mature B-cell lymphocytic neoplasm",
          "mature B-cell neoplasm",
          "mature B-cell neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004949"
    },
    {
      "id": 17548,
      "label": "primary organ-specific lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6792
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021064",
          "MEDGEN:1826175",
          "NCIT:C7185",
          "Orphanet:279911",
          "UMLS:C5680788"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0017207"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021147",
          "MEDGEN:797800",
          "MedDRA:10068349",
          "Orphanet:289644",
          "UMLS:C2363744"
        ],
        "synonyms": [
          "EBV-associated lymphoproliferative disorder",
          "Epstein-Barr virus-associated malignant lymphoproliferative disorder"
        ],
        "definition": "A range of lymphoproliferative diseases characterized by uncontrolled proliferation of B cells, T cells, or NK cells infected with Epstein-Barr virus. Depending on host immunity and viral factors, viral persistence in host cells can induce lymphoproliferation with a diverse clinical spectrum ranging from simple reactive hyperplasia to aggressive lymphoma/leukemia with unique clinical and pathological presentations."
      },
      "child_count": 11,
      "reference_id": "MONDO:0017343"
    }
  ],
  "children": [
    {
      "id": 4066,
      "label": "spinal cord lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4634,
        5449
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14150",
          "GARD:0023030",
          "MEDGEN:236836",
          "NCIT:C5157",
          "UMLS:C1336044"
        ],
        "synonyms": [
          "lymphoma of spinal cord",
          "lymphoma of the spinal cord",
          "primary spinal cord lymphoma",
          "spinal cord lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the spinal cord as a primary lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001892"
    },
    {
      "id": 5543,
      "label": "cerebral lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4634,
        4768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5815",
          "GARD:0023605",
          "MEDGEN:116109",
          "NCIT:C7611",
          "SCTID:276836002",
          "UMLS:C0240803"
        ],
        "synonyms": [
          "cerebral lymphoma",
          "primary lymphoma of the cerebrum",
          "primary lymphoma, brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the cerebral hemispheres as a primary lesion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003655"
    },
    {
      "id": 23470,
      "label": "central nervous system non-hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4634,
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025918",
          "MEDGEN:745669",
          "NCIT:C114779",
          "SCTID:448254007",
          "UMLS:C2213246"
        ],
        "synonyms": [
          "Central nervous system non-Hodgkin lymphoma",
          "Primary Central nervous system non-Hodgkin lymphoma",
          "central nervous system non-Hodgkin lymphoma",
          "non-Hodgkin lymphoma of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin lymphoma that arises from the central nervous system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044887"
    }
  ],
  "roots": [
    {
      "id": 3028,
      "label": "immune system cancer"
    },
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 5530,
      "label": "central nervous system hematopoietic neoplasm"
    },
    {
      "id": 6694,
      "label": "neoplasm of mature B-cells"
    },
    {
      "id": 17548,
      "label": "primary organ-specific lymphoma"
    },
    {
      "id": 17660,
      "label": "Epstein-Barr virus-associated lymphoproliferative disorder"
    }
  ]
}