{
  "id": 4668,
  "label": "bone angiosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002617",
  "properties": {
    "xrefs": [
      "DOID:3351",
      "GARD:0023189",
      "MEDGEN:231448",
      "NCIT:C6479",
      "UMLS:C1332574"
    ],
    "synonyms": [
      "angiosarcoma (disease) of bone tissue",
      "bone Hemangioendothelial sarcoma",
      "bone angioendothelial sarcoma",
      "bone angiosarcoma",
      "bone hemangiosarcoma",
      "bone tissue angiosarcoma (disease)",
      "osseous angioendothelial sarcoma",
      "osseous angiosarcoma",
      "osseous hemangiosarcoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A high-grade malignant vascular neoplasm that arises from the bone. It is characterized by the presence of neoplastic cells with endothelial differentiation."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17394,
      "label": "angiosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4233,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0001816",
          "EFO:0003968",
          "GARD:0020900",
          "HP:0200058",
          "ICD9:171.9",
          "ICDO:9120/3",
          "MEDGEN:42385",
          "MESH:D006394",
          "MedDRA:10002476",
          "NCIT:C3088",
          "ONCOTREE:ANGS",
          "Orphanet:263413",
          "SCTID:403977003",
          "UMLS:C0018923"
        ],
        "synonyms": [
          "angiosarcoma",
          "angiosarcoma (disease)",
          "blood vessel sarcoma",
          "hemangiosarcoma",
          "hemangiosarcoma, malignant",
          "malignant angioendothelioma",
          "malignant hemangioendothelioma",
          "sarcoma of blood vessel",
          "vascular sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A malignant tumor arising from the endothelial cells of the blood vessels. Microscopically, it is characterized by frequently open vascular anastomosing and branching channels. The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei. Angiosarcomas most frequently occur in the skin and breast. Patients with long-standing lymphedema are at increased risk of developing angiosarcoma."
      },
      "child_count": 38,
      "reference_id": "MONDO:0016982"
    },
    {
      "id": 20297,
      "label": "bone sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080639",
          "GARD:0020547",
          "ICD9:170.9",
          "MEDGEN:352831",
          "MedDRA:10006007",
          "NCIT:C9312",
          "Orphanet:223727",
          "SCTID:448710000",
          "UMLS:C1704327"
        ],
        "synonyms": [
          "bone sarcoma",
          "osseous sarcoma",
          "sarcoma of bone",
          "sarcoma of the bone",
          "skeletal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcoma that arises from the bone. Representative examples are osteosarcoma and chondrosarcoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021054"
    },
    {
      "id": 21452,
      "label": "vascular bone neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18958,
        21330
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025402",
          "MEDGEN:234986",
          "NCIT:C6478",
          "UMLS:C1336946"
        ],
        "synonyms": [
          "bone vascular neoplasm",
          "bone vascular tumor",
          "bone vascular tumour",
          "osseous vascular neoplasm",
          "osseous vascular tumor",
          "osseous vascular tumour",
          "vascular bone neoplasm",
          "vascular neoplasm of bone",
          "vascular neoplasm of the bone",
          "vascular tumor of bone",
          "vascular tumor of the bone",
          "vascular tumour of bone",
          "vascular tumour of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant vascular neoplasm that arises from the bone."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024499"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17394,
      "label": "angiosarcoma"
    },
    {
      "id": 20297,
      "label": "bone sarcoma"
    },
    {
      "id": 21452,
      "label": "vascular bone neoplasm"
    }
  ]
}