{
  "id": 4676,
  "label": "Ewing sarcoma of bone",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002625",
  "properties": {
    "xrefs": [
      "DOID:3368",
      "GARD:0023194",
      "ICD9:170.9",
      "MEDGEN:108438",
      "NCIT:C4835",
      "SCTID:307608006",
      "UMLS:C0585474"
    ],
    "synonyms": [
      "Ewing sarcoma of bone",
      "Ewing's sarcoma of bone",
      "Ewing's sarcoma, osseous",
      "Ewing's sarcoma/bone peripheral primitive neuroectodermal tumour",
      "bone Ewing's sarcoma",
      "bone localised Ewing sarcoma",
      "bone localised Ewing's sarcoma",
      "bone tissue Ewing sarcoma",
      "localised skeletal Ewing's sarcoma",
      "osseous Ewing's sarcoma",
      "osseous Ewing's tumor",
      "osseous Ewing's tumour",
      "skeletal Ewing's sarcoma",
      "skeletal Ewing's tumor",
      "skeletal Ewing's tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A small round cell bone tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones. Clinical findings include pain and a mass in the involved area. fever, anemia, leukocytosis, and an increased sedimentation rate are often seen. X-ray examination reveals osteolytic lesions. The prognosis depends on the stage, anatomic location, and size of the tumor."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13857,
      "label": "Ewing sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6816,
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3369",
          "EFO:0000174",
          "GARD:0006390",
          "ICDO:9260/3",
          "MEDGEN:107816",
          "MESH:D012512",
          "MedDRA:10015560",
          "NANDO:2200053",
          "NCIT:C4817",
          "OMIM:612219",
          "ONCOTREE:ES",
          "Orphanet:319",
          "UMLS:C0553580",
          "icd11.foundation:458106328"
        ],
        "synonyms": [
          "ES",
          "Ewing sarcoma",
          "Ewing's family localised tumour",
          "Ewing's sarcoma",
          "Ewing's tumor",
          "Ewing's tumour",
          "Ewing tumor",
          "Ewing tumour",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumour",
          "Ewings sarcoma-primitive neuroectodermal tumor",
          "Ewings sarcoma-primitive neuroectodermal tumour",
          "localised Ewing sarcoma",
          "localised Ewing's sarcoma",
          "localised Ewing's sarcoma/peripheral primitive neuroectodermal tumour",
          "localised Ewing's tumour",
          "localised peripheral primitive neuroectodermal tumour",
          "localized Ewing sarcoma",
          "localized Ewing's sarcoma",
          "localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor",
          "localized Ewing's tumor",
          "localized peripheral primitive neuroectodermal tumor",
          "neuroepithelioma",
          "neuroepithelioma, peripheral",
          "peripheral primitive neuroectodermal tumour",
          "sarcoma, Ewing's"
        ],
        "definition": "A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0012817"
    },
    {
      "id": 20297,
      "label": "bone sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080639",
          "GARD:0020547",
          "ICD9:170.9",
          "MEDGEN:352831",
          "MedDRA:10006007",
          "NCIT:C9312",
          "Orphanet:223727",
          "SCTID:448710000",
          "UMLS:C1704327"
        ],
        "synonyms": [
          "bone sarcoma",
          "osseous sarcoma",
          "sarcoma of bone",
          "sarcoma of the bone",
          "skeletal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcoma that arises from the bone. Representative examples are osteosarcoma and chondrosarcoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021054"
    },
    {
      "id": 20361,
      "label": "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18958,
        20283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025291",
          "MEDGEN:272598",
          "NCIT:C35871",
          "UMLS:C1333481"
        ],
        "synonyms": [
          "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumor of bone",
          "Ewing's sarcoma/peripheral primitive neuroectodermal tumour of bone",
          "bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumor",
          "bone tissue Ewing sarcoma/peripheral primitive neuroectodermal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A spectrum of malignant tumors arising from the bone and characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms."
      },
      "child_count": 4,
      "reference_id": "MONDO:0021123"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:473110",
          "NCIT:C97075",
          "SCTID:363045008",
          "UMLS:C0410787"
        ],
        "synonyms": [
          "Mendelian connective tissue disorder",
          "connective tissue hereditary disorder",
          "hereditary connective tissue disorder",
          "Hereditary Connective Tissue Disorder",
          "Inherited disorder of connective tissue",
          "inherited disorder of connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An inherited genetic disorder that affects the connective tissues. Representative examples include Ehlers-Danlos syndrome and Marfan syndrome."
      },
      "child_count": 176,
      "reference_id": "MONDO:0023603"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13857,
      "label": "Ewing sarcoma"
    },
    {
      "id": 20297,
      "label": "bone sarcoma"
    },
    {
      "id": 20361,
      "label": "Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue"
    }
  ]
}