{
  "id": 4679,
  "label": "peripheral osteosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002628",
  "properties": {
    "xrefs": [
      "DOID:3374",
      "GARD:0023196",
      "MEDGEN:272379",
      "NCIT:C7134",
      "UMLS:C1332591"
    ],
    "synonyms": [
      "bone surface (peripheral) osteosarcoma",
      "peripheral osteosarcoma",
      "surface osteosarcoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the surface of the bone."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4680,
      "label": "bone osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3376",
          "GARD:0007284",
          "ICD9:170.9",
          "MEDGEN:108437",
          "MedDRA:10031291",
          "NCIT:C53707",
          "OMIM:259500",
          "Orphanet:668",
          "SCTID:307576001",
          "UMLS:C0585442"
        ],
        "synonyms": [
          "bone osteosarcoma",
          "osteosarcoma of bone",
          "osteosarcoma, somatic",
          "osteosarcoma, somatic mutation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002629"
    }
  ],
  "children": [
    {
      "id": 5757,
      "label": "periosteal osteogenic sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6489",
          "GARD:0023719",
          "ICDO:9193/3",
          "MEDGEN:234607",
          "NCIT:C8970",
          "ONCOTREE:PEOS",
          "UMLS:C1377843"
        ],
        "synonyms": [
          "juxtacortical chondroblastic osteosarcoma",
          "periosteal osteosarcoma",
          "periosteal osteosarcoma (morphologic abnormality)",
          "PEOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An intermediate grade malignant bone-forming mesenchymal neoplasm with chondroblastic differentiation. It arises from the surface of the bone and affects the diaphysis or diaphyseal- metaphyseal portion of the long bones. A painless mass or swelling is the most common clinical sign. It is associated with a better prognosis than conventional osteosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003895"
    },
    {
      "id": 7796,
      "label": "high grade surface osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000296",
          "GARD:0024346",
          "ICDO:9194/3",
          "MEDGEN:220428",
          "NCIT:C53958",
          "ONCOTREE:HGSOS",
          "UMLS:C1266165"
        ],
        "synonyms": [
          "high grade surface osteosarcoma",
          "high-grade surface osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive high grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006246"
    },
    {
      "id": 8265,
      "label": "juxtacortical osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4679
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3373",
          "EFO:1001000",
          "GARD:0024479",
          "ICDO:9192/3",
          "MEDGEN:60197",
          "MESH:D018217",
          "NCIT:C8969",
          "ONCOTREE:PAOS",
          "UMLS:C0206642"
        ],
        "synonyms": [
          "juxtacortical osteogenic sarcoma",
          "juxtacortical osteosarcoma",
          "parosteal osteogenic sarcoma",
          "parosteal osteosarcoma",
          "PAOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A low grade malignant bone-forming mesenchymal neoplasm arising from the surface of the bone. It usually affects the distal posterior femur, the proximal tibia, and proximal humerus. Painless swelling is the usual clinical sign. Most patients are young adults and the prognosis is usually excellent."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006817"
    }
  ],
  "roots": [
    {
      "id": 4680,
      "label": "bone osteosarcoma"
    }
  ]
}