{
  "id": 4680,
  "label": "bone osteosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002629",
  "properties": {
    "xrefs": [
      "DOID:3376",
      "GARD:0007284",
      "ICD9:170.9",
      "MEDGEN:108437",
      "MedDRA:10031291",
      "NCIT:C53707",
      "OMIM:259500",
      "Orphanet:668",
      "SCTID:307576001",
      "UMLS:C0585442"
    ],
    "synonyms": [
      "bone osteosarcoma",
      "osteosarcoma of bone",
      "osteosarcoma, somatic",
      "osteosarcoma, somatic mutation"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 11016,
      "label": "osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3347",
          "EFO:0000637",
          "HP:0002669",
          "ICDO:9180/3",
          "MEDGEN:10501",
          "MESH:D012516",
          "NANDO:2200048",
          "NCIT:C9145",
          "ONCOTREE:OS",
          "UMLS:C0029463"
        ],
        "synonyms": [
          "bone tissue neoplasm",
          "osteogenic sarcoma",
          "osteoid sarcoma",
          "osteosarcoma",
          "osteosarcoma (disease)",
          "osteosarcoma, malignant",
          "sarcoma of osteoid"
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 6,
      "reference_id": "MONDO:0009807"
    },
    {
      "id": 20297,
      "label": "bone sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080639",
          "GARD:0020547",
          "ICD9:170.9",
          "MEDGEN:352831",
          "MedDRA:10006007",
          "NCIT:C9312",
          "Orphanet:223727",
          "SCTID:448710000",
          "UMLS:C1704327"
        ],
        "synonyms": [
          "bone sarcoma",
          "osseous sarcoma",
          "sarcoma of bone",
          "sarcoma of the bone",
          "skeletal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcoma that arises from the bone. Representative examples are osteosarcoma and chondrosarcoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021054"
    }
  ],
  "children": [
    {
      "id": 4679,
      "label": "peripheral osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3374",
          "GARD:0023196",
          "MEDGEN:272379",
          "NCIT:C7134",
          "UMLS:C1332591"
        ],
        "synonyms": [
          "bone surface (peripheral) osteosarcoma",
          "peripheral osteosarcoma",
          "surface osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the surface of the bone."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002628"
    },
    {
      "id": 4682,
      "label": "conventional osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3378",
          "DOID:7602",
          "GARD:0023198",
          "ICDO:9186/3",
          "ICDO:9195/3",
          "MEDGEN:1843980",
          "NCIT:C35870",
          "UMLS:C5848244"
        ],
        "synonyms": [
          "central osteosarcoma",
          "conventional central osteosarcoma",
          "conventional osteosarcoma",
          "intracortical osteogenic sarcoma",
          "intracortical osteosarcoma",
          "intracortical osteosarcoma (morphologic abnormality)",
          "medullary osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. The tumor arises from the medullary portion of the bone. It affects the long bones and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002631"
    },
    {
      "id": 4683,
      "label": "metachronous osteosarcoma of the bone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3379",
          "GARD:0023199",
          "MEDGEN:233695",
          "NCIT:C38157",
          "UMLS:C1334704"
        ],
        "synonyms": [
          "metachronous osteosarcoma",
          "metachronous osteosarcoma of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A bone osteosarcoma that has metastasized to skeletal or extraskeletal sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002632"
    },
    {
      "id": 5891,
      "label": "telangiectatic osteogenic sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6951",
          "GARD:0023793",
          "ICDO:9183/3",
          "MEDGEN:78059",
          "NCIT:C3902",
          "ONCOTREE:TEOS",
          "UMLS:C0259782"
        ],
        "synonyms": [
          "malignant bone aneurysm",
          "telangiectatic osteosarcoma",
          "telangiectatic osteosarcoma (morphologic abnormality)",
          "TEOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of a cystic architecture with blood-filled spaces. The prognosis is similar to that of conventional osteosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004050"
    },
    {
      "id": 6094,
      "label": "osteosarcoma arising in bone Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4505,
        4680,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7542",
          "GARD:0023906",
          "ICDO:9184/3",
          "MEDGEN:569679",
          "NCIT:C6469",
          "UMLS:C0334546"
        ],
        "synonyms": [
          "Paget osteosarcoma",
          "Paget's osteosarcoma",
          "osteosarcoma arising in Paget disease of bone",
          "osteosarcoma arising in Paget's disease of bone",
          "osteosarcoma arising in bone Paget's disease",
          "osteosarcoma arising in osseous Paget's disease",
          "osteosarcoma arising in osteitis deformans"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004275"
    }
  ],
  "roots": [
    {
      "id": 11016,
      "label": "osteosarcoma"
    },
    {
      "id": 20297,
      "label": "bone sarcoma"
    }
  ]
}