{
  "id": 4682,
  "label": "conventional osteosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002631",
  "properties": {
    "xrefs": [
      "DOID:3378",
      "DOID:7602",
      "GARD:0023198",
      "ICDO:9186/3",
      "ICDO:9195/3",
      "MEDGEN:1843980",
      "NCIT:C35870",
      "UMLS:C5848244"
    ],
    "synonyms": [
      "central osteosarcoma",
      "conventional central osteosarcoma",
      "conventional osteosarcoma",
      "intracortical osteogenic sarcoma",
      "intracortical osteosarcoma",
      "intracortical osteosarcoma (morphologic abnormality)",
      "medullary osteosarcoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A high grade malignant bone-forming mesenchymal neoplasm producing osteoid. The tumor arises from the medullary portion of the bone. It affects the long bones and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4680,
      "label": "bone osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3376",
          "GARD:0007284",
          "ICD9:170.9",
          "MEDGEN:108437",
          "MedDRA:10031291",
          "NCIT:C53707",
          "OMIM:259500",
          "Orphanet:668",
          "SCTID:307576001",
          "UMLS:C0585442"
        ],
        "synonyms": [
          "bone osteosarcoma",
          "osteosarcoma of bone",
          "osteosarcoma, somatic",
          "osteosarcoma, somatic mutation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002629"
    }
  ],
  "children": [
    {
      "id": 4678,
      "label": "chondroblastic osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3372",
          "GARD:0023195",
          "ICDO:9181/3",
          "MEDGEN:79013",
          "NCIT:C4021",
          "ONCOTREE:CHOS",
          "UMLS:C0279603"
        ],
        "synonyms": [
          "chondroblastic osteogenic sarcoma",
          "chondroblastic osteosarcoma",
          "chondroblastic osteosarcoma (morphologic abnormality)",
          "CHOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An osteosarcoma characterized by the presence of atypical cartilage of variable cellularity. It may or may not be associated with the presence of myxoid areas or focal bone formation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002627"
    },
    {
      "id": 6117,
      "label": "fibrosarcomatous osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7603",
          "GARD:0023921",
          "ICDO:9182/3",
          "MEDGEN:79012",
          "NCIT:C4020",
          "ONCOTREE:FIOS",
          "UMLS:C0279602"
        ],
        "synonyms": [
          "fibroblastic osteogenic sarcoma",
          "fibroblastic osteosarcoma",
          "fibroblastic osteosarcoma (morphologic abnormality)",
          "fibrosarcomatous osteogenic sarcoma",
          "fibrosarcomatous osteosarcoma",
          "FIOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A conventional osteosarcoma characterized by the presence of spindle shaped cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004301"
    },
    {
      "id": 6122,
      "label": "childhood intracortical osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4674,
        4682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7612",
          "GARD:0023922",
          "MEDGEN:232350",
          "NCIT:C6590",
          "UMLS:C1332974"
        ],
        "synonyms": [
          "childhood conventional osteosarcoma",
          "childhood intracortical osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A high grade malignant bone-forming mesenchymal neoplasm that produces osteoid and occurs in childhood. It arises from the medullary portion of the bone. It affects the long bones, and most commonly, the distal femur, proximal tibia, and proximal humerus. Pain with or without a palpable mass is the most common clinical presentation. It usually has an aggressive growth and may metastasize through the hematogenous route. The lung is the most frequent site of metastasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004306"
    },
    {
      "id": 20073,
      "label": "osteoblastic osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025203",
          "MEDGEN:312376",
          "NCIT:C53953",
          "UMLS:C1704328"
        ],
        "synonyms": [
          "osteoblastic osteosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A conventional osteosarcoma characterized by the predominance of osteoid matrix."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020660"
    }
  ],
  "roots": [
    {
      "id": 4680,
      "label": "bone osteosarcoma"
    }
  ]
}