{
  "id": 4688,
  "label": "histiocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002637",
  "properties": {
    "xrefs": [
      "DOID:3405",
      "MEDGEN:6845",
      "MESH:D015614",
      "NANDO:2100005",
      "NCIT:C3106",
      "ONCOTREE:HDCN",
      "UMLS:C0019618"
    ],
    "synonyms": [
      "histiocytic infiltrate",
      "histiocytic syndrome",
      "histiocytic and dendritic cell neoplasms"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7447,
      "label": "lymphatic system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23494
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:75",
          "EFO:0007352",
          "MEDGEN:892707",
          "MESH:D008206",
          "NCIT:C50764",
          "SCTID:362971004",
          "UMLS:C4021976"
        ],
        "synonyms": [
          "disease of lymphatic part of lymphoid system",
          "disease or disorder of lymphatic part of lymphoid system",
          "disorder of lymphatic part of lymphoid system",
          "glands, swollen",
          "lymphatic disease",
          "lymphatic part of lymphoid system disease",
          "lymphatic part of lymphoid system disease or disorder",
          "swollen gland",
          "swollen glands",
          "lymphadenopathy",
          "lymphangiopathy",
          "adenopathy",
          "disease of lympoid system",
          "disorder of lymphoid system",
          "lympoid system disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease involving the lymphatic part of lymphoid system."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005833"
    }
  ],
  "children": [
    {
      "id": 4986,
      "label": "reticulohistiocytic granuloma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4688
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4394",
          "GARD:0012967",
          "ICD9:277.89",
          "MEDGEN:48431",
          "NCIT:C3356",
          "SCTID:404162004",
          "UMLS:C0035290"
        ],
        "synonyms": [
          "reticulohistiocytic granuloma (morphologic abnormality)",
          "solitary Reticulohistiocytoma",
          "solitary reticulohistiocytoma",
          "solitary histiocytoma",
          "solitary reticulohistiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare cutaneous lesion composed of eosinophilic histiocytes, which are often multinucleated. The lesions are yellow-brown papules affecting any part of the body. Patients are usually adult men. The prognosis is excellent. -- 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002984"
    },
    {
      "id": 6401,
      "label": "malignant histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4688
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2570",
          "DOID:8580",
          "ICD9:202.3",
          "ICDO:9750/3",
          "MEDGEN:5569",
          "MESH:D015620",
          "NCIT:C7202",
          "SCTID:118612006",
          "UMLS:C0019623"
        ],
        "synonyms": [
          "Stewart's granuloma",
          "histiocytic medullary reticulosis",
          "malignant histiocytic disease",
          "malignant midline reticulosis",
          "malignant reticulosis",
          "disorders, malignant histiocytic",
          "histiocytic disorder, malignant",
          "malignant histiocytic disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of macrophages and dendritic cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004612"
    },
    {
      "id": 16345,
      "label": "non-Langerhans cell histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4688
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4330",
          "GARD:0008231",
          "ICD9:288.4",
          "MEDGEN:9265",
          "MESH:D015616",
          "Orphanet:157987",
          "SCTID:127069007",
          "UMLS:C0019624"
        ],
        "synonyms": [
          "non-Langerhans-cell histiocytosis",
          "histiocytosis, non-Langerhans-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; juvenile XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES)."
      },
      "child_count": 15,
      "reference_id": "MONDO:0015531"
    },
    {
      "id": 18407,
      "label": "Langerhans cell histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4688,
        6569,
        19729,
        21541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2571",
          "EFO:1000318",
          "GARD:0006858",
          "ICD9:202.5",
          "ICD9:277.89",
          "ICDO:9751/1",
          "ICDO:9751/3",
          "ICDO:9752/1",
          "ICDO:9753/1",
          "ICDO:9754/3",
          "MEDGEN:5568",
          "MedDRA:10069698",
          "NANDO:2200031",
          "NCIT:C3107",
          "NORD:1348",
          "OMIM:604856",
          "ONCOTREE:LCH",
          "Orphanet:389",
          "SCTID:65399007",
          "UMLS:C0019621",
          "icd11.foundation:1388720498",
          "icd11.foundation:216625985"
        ],
        "synonyms": [
          "LCH",
          "Langerhans cell granulomatosis",
          "Langerhans cell histiocytosis",
          "Langerhans cell histiocytosis, NOS",
          "Langerhans cell histiocytosis, Not otherwise specified",
          "histiocytosis X",
          "Langerhans-cell histiocytosis",
          "Lch"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues."
      },
      "child_count": 32,
      "reference_id": "MONDO:0018310"
    },
    {
      "id": 20843,
      "label": "ALK+ histiocytosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4688
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "anaplastic lymphoma kinase positive histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0022338"
    }
  ],
  "roots": [
    {
      "id": 7447,
      "label": "lymphatic system disorder"
    }
  ]
}