{
  "id": 4699,
  "label": "mammary Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002648",
  "properties": {
    "xrefs": [
      "DOID:3443",
      "ICDO:8540/3",
      "MEDGEN:18263",
      "MESH:D010144",
      "NCIT:C47857",
      "UMLS:C0030185"
    ],
    "synonyms": [
      "Paget disease of the breast",
      "Paget's disease of breast",
      "Paget's disease of the breast",
      "breast Paget disease",
      "mammary Paget disease",
      "mammary Paget's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A malignant neoplasm in which there is infiltration of the skin overlying the breast by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It is almost always associated with an intraductal or invasive ductal carcinoma of the breast. The clinical features include focal skin reddening, and eczema. Retraction of the nipple may sometimes occur."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    },
    {
      "id": 20398,
      "label": "Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:277958",
          "NCIT:C7073",
          "UMLS:C1368019"
        ],
        "synonyms": [
          "Paget cell neoplasm",
          "Paget disease",
          "Paget's cell neoplasm",
          "Paget's disease"
        ],
        "definition": "A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells). Paget cell neoplasms include Paget disease of the nipple and extramammary Paget disease which may affect the vulva, penis, anus, skin and scrotum."
      },
      "child_count": 5,
      "reference_id": "MONDO:0021165"
    }
  ],
  "children": [
    {
      "id": 16599,
      "label": "Paget disease of the nipple",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4699,
        5808
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007303",
          "MEDGEN:352830",
          "MedDRA:10033367",
          "NCIT:C3301",
          "NORD:1544",
          "ONCOTREE:PD",
          "Orphanet:180275",
          "SCTID:403946000",
          "UMLS:C1704323",
          "icd11.foundation:1295910447"
        ],
        "synonyms": [
          "Paget disease of the breast",
          "mammary Paget disease",
          "Paget disease of the nipple",
          "Paget's Disease of the Breast",
          "Paget's disease of nipple",
          "Paget's disease of the nipple",
          "nipple Paget's disease",
          "PD",
          "Paget's disease, mammary"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015873"
    }
  ],
  "roots": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma"
    },
    {
      "id": 20398,
      "label": "Paget disease"
    }
  ]
}