{
  "id": 4702,
  "label": "anal Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002651",
  "properties": {
    "xrefs": [
      "DOID:3446",
      "GARD:0023203",
      "MEDGEN:233981",
      "NCIT:C5598",
      "UMLS:C1332274"
    ],
    "synonyms": [
      "Paget disease of the anus",
      "Paget's disease of anus",
      "Paget's disease of the anus",
      "anal Paget disease",
      "anal Paget's disease",
      "anus Paget disease",
      "anus mammary Paget's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A slowly spreading, erythematous eczematoid plaque in the anal region. Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei. Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma. The other half of the cases, have a high local recurrence rate and they may become invasive (WHO)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4295,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3447",
          "GARD:0027609",
          "MEDGEN:233976",
          "NCIT:C5600",
          "SCTID:423607006",
          "UMLS:C1332257"
        ],
        "synonyms": [
          "adenocarcinoma of anus",
          "adenocarcinoma of the anus",
          "anal adenocarcinoma",
          "anus adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002652"
    },
    {
      "id": 9488,
      "label": "extramammary Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000249",
          "GARD:0004192",
          "ICDO:8542/3",
          "MEDGEN:45280",
          "MESH:D010145",
          "MedDRA:10033366",
          "MedDRA:10068223",
          "NCIT:C3302",
          "OMIM:167300",
          "ONCOTREE:EMPD",
          "Orphanet:2800",
          "UMLS:C0030186",
          "icd11.foundation:1796624917"
        ],
        "synonyms": [
          "Extramammary Paget's disease",
          "Paget disease Extramammary",
          "Paget's disease of skin",
          "Paget's disease of the skin",
          "Paget's skin disease",
          "extramammary Paget disease",
          "EMPD",
          "Paget disease, EXTRAMAMMARY",
          "cutaneous Paget's disease"
        ],
        "definition": "A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells). It may affect the anus, penis, scrotum, and vulva."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008177"
    }
  ],
  "children": [
    {
      "id": 6153,
      "label": "perianal skin Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4702,
        4706,
        4946
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7708",
          "GARD:0023944",
          "MEDGEN:231372",
          "NCIT:C7476",
          "UMLS:C1332270"
        ],
        "synonyms": [
          "Paget disease of the anal margin",
          "Paget's disease of the anal margin",
          "anal margin Paget's disease",
          "perianal skin Paget disease",
          "perianal skin Paget's disease",
          "perianal skin mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Paget disease involving the perianal skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004337"
    },
    {
      "id": 6274,
      "label": "anal canal Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4702,
        4771
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8119",
          "GARD:0024022",
          "MEDGEN:231062",
          "NCIT:C7477",
          "SCTID:236811000119101",
          "UMLS:C1332261"
        ],
        "synonyms": [
          "Paget disease of the anal canal",
          "Paget's disease of anal canal",
          "Paget's disease of the anal canal",
          "anal canal Paget disease",
          "anal canal Paget's disease",
          "anal canal mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Paget disease involving the squamous epithelium of the anal canal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004468"
    }
  ],
  "roots": [
    {
      "id": 4703,
      "label": "anus adenocarcinoma"
    },
    {
      "id": 9488,
      "label": "extramammary Paget disease"
    }
  ]
}