{
  "id": 4703,
  "label": "anus adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002652",
  "properties": {
    "xrefs": [
      "DOID:3447",
      "GARD:0027609",
      "MEDGEN:233976",
      "NCIT:C5600",
      "SCTID:423607006",
      "UMLS:C1332257"
    ],
    "synonyms": [
      "adenocarcinoma of anus",
      "adenocarcinoma of the anus",
      "anal adenocarcinoma",
      "anus adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts. The prognosis is related to the stage at diagnosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1996",
          "EFO:0005631",
          "MEDGEN:56214",
          "NCIT:C9383",
          "ONCOTREE:READ",
          "SCTID:254582000",
          "UMLS:C0149978",
          "icd11.foundation:1316028436"
        ],
        "synonyms": [
          "adenocarcinoma - rectum",
          "adenocarcinoma of rectum",
          "adenocarcinoma of the rectum",
          "rectal adenocarcinoma",
          "rectum adenocarcinoma",
          "read"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002169"
    },
    {
      "id": 5158,
      "label": "anal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4054,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4908",
          "GARD:0027634",
          "MEDGEN:76006",
          "NCIT:C9291",
          "SCTID:448315008",
          "UMLS:C0279637"
        ],
        "synonyms": [
          "Ca anus",
          "anal cancer",
          "cancer of anus",
          "cancer of the anus",
          "anal carcinoma",
          "anus carcinoma",
          "carcinoma of anus",
          "carcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anus"
      },
      "child_count": 8,
      "reference_id": "MONDO:0003199"
    }
  ],
  "children": [
    {
      "id": 4702,
      "label": "anal Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4703,
        9488
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3446",
          "GARD:0023203",
          "MEDGEN:233981",
          "NCIT:C5598",
          "UMLS:C1332274"
        ],
        "synonyms": [
          "Paget disease of the anus",
          "Paget's disease of anus",
          "Paget's disease of the anus",
          "anal Paget disease",
          "anal Paget's disease",
          "anus Paget disease",
          "anus mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A slowly spreading, erythematous eczematoid plaque in the anal region. Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei. Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma. The other half of the cases, have a high local recurrence rate and they may become invasive (WHO)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002651"
    },
    {
      "id": 4770,
      "label": "anal mucinous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4703,
        4783
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3691",
          "GARD:0027616",
          "MEDGEN:233980",
          "NCIT:C5606",
          "UMLS:C1332272"
        ],
        "synonyms": [
          "anal colloid adenocarcinoma",
          "anal colloidal adenocarcinoma",
          "anal mucinous adenocarcinoma",
          "anus mucinous adenocarcinoma",
          "colloid adenocarcinoma of anus",
          "colloid adenocarcinoma of the anus",
          "colloidal adenocarcinoma of anus",
          "colloidal adenocarcinoma of the anus",
          "mucinous adenocarcinoma of anus",
          "mucinous adenocarcinoma of the anus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal adenocarcinoma characterized by the presence of mucoid stroma formation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002734"
    },
    {
      "id": 4771,
      "label": "anal canal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4703,
        8521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3692",
          "GARD:0021773",
          "HP:0030439",
          "MEDGEN:233977",
          "NCIT:C7471",
          "Orphanet:424016",
          "SCTID:764845008",
          "UMLS:C1332259",
          "icd11.foundation:168138050"
        ],
        "synonyms": [
          "adenocarcinoma arising in anal mucosa",
          "adenocarcinoma arising in the anal mucosa",
          "adenocarcinoma of anal canal",
          "adenocarcinoma of the anal canal",
          "anal canal adenocarcinoma",
          "anal canal adenocarcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal adenocarcinoma arising from the anal canal mucosa. Morphologically, it resembles the adenocarcinoma which arises from the colorectal glandular epithelium. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002735"
    },
    {
      "id": 6086,
      "label": "anal gland adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4703
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7531",
          "GARD:0027672",
          "ICDO:8215/3",
          "MEDGEN:220409",
          "NCIT:C5609",
          "ONCOTREE:AGA",
          "UMLS:C1266027"
        ],
        "synonyms": [
          "adenocarcinoma of the anal gland",
          "anal glands adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An anal adenocarcinoma arising from the epithelium of the anal glands. The overlying anal mucosa does not show evidence of neoplastic changes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004266"
    }
  ],
  "roots": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma"
    },
    {
      "id": 5158,
      "label": "anal carcinoma"
    }
  ]
}