{ "id": 4707, "label": "skin carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0002656", "properties": { "xrefs": [ "DOID:3451", "EFO:0009259", "MEDGEN:195945", "NCIT:C4914", "UMLS:C0699893" ], "synonyms": [ "carcinoma of skin", "carcinoma of the skin", "carcinoma of zone of skin", "non-melanoma cancer of skin", "non-melanoma cancer of the skin", "non-melanoma skin cancer", "nonmelanoma skin cancer", "skin cancer, non-melanoma", "skin carcinoma", "zone of skin carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the zone of skin" }, "isLeaf": false, "isRoot": false, "child_count": 13, "parents": [ { "id": 4907, "label": "skin cancer", "isLeaf": false, "isRoot": false, "parents": [ 3053, 4599 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4159", "ICD10CM:C43-C44", "ICD9:173.8", "ICD9:173.9", "MEDGEN:40101", "NCIT:C2920", "SCTID:372130007", "UMLS:C0007114", "icd11.foundation:1706880799" ], "synonyms": [ "cancer of zone of skin", "malignant neoplasm of skin", "malignant neoplasm of the skin", "malignant neoplasm of zone of skin", "malignant skin neoplasm", "malignant skin tumor", "malignant skin tumour", "malignant tumor of skin", "malignant tumor of the skin", "malignant tumour of skin", "malignant tumour of the skin", "malignant zone of skin neoplasm", "melanoma and non-melanoma skin cancer", "skin cancer", "skin cancer, Including melanoma", "skin neoplasm, malignant", "zone of skin cancer" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A malignant neoplasm involving the zone of skin" }, "child_count": 26, "reference_id": "MONDO:0002898" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" }, { "id": 20690, "label": "epithelial skin neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4599, 7265 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:91063", "NCIT:C7342", "UMLS:C0345976" ], "synonyms": [ "epithelial skin neoplasm", "epithelial skin tumor", "epithelial skin tumour", "skin epithelium neoplasm", "skin epithelium tumor", "skin epithelium tumour", "zone of skin epithelial neoplasm" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A epithelial neoplasm that involves the zone of skin." }, "child_count": 10, "reference_id": "MONDO:0021634" } ], "children": [ { "id": 3800, "label": "labia minora carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3733, 4707, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1293", "GARD:0022971", "MEDGEN:233605", "NCIT:C9364", "UMLS:C1334357" ], "synonyms": [ "labia minora cancer", "carcinoma of labia minora", "carcinoma of labium minora", "carcinoma of the labia minora", "labia minora carcinoma", "labium minora carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the labia minora." }, "child_count": 0, "reference_id": "MONDO:0001602" }, { "id": 3890, "label": "labia majora carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3624, 4707, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13389", "GARD:0022990", "MEDGEN:235247", "NCIT:C9363", "UMLS:C1334356" ], "synonyms": [ "carcinoma of labia majora", "carcinoma of labium majora", "carcinoma of the labia majora", "labia majora cancer", "labia majora carcinoma", "labium majora carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the labia majora." }, "child_count": 0, "reference_id": "MONDO:0001702" }, { "id": 4598, "label": "skin squamous cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4707, 6823 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3151", "MEDGEN:107512", "NCIT:C4819", "ONCOTREE:CSCC", "SCTID:254651007", "UMLS:C0553723", "icd11.foundation:1448983042" ], "synonyms": [ "cutaneous squamous cell carcinoma", "epidermoid carcinoma of skin", "epidermoid carcinoma of the skin", "epidermoid skin carcinoma", "skin squamous cell cancer", "skin squamous cell carcinoma", "squamous cell carcinoma - skin", "squamous cell carcinoma of skin", "squamous cell carcinoma of the skin", "squamous cell skin carcinoma", "zone of skin squamous cell carcinoma", "CSCC" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated." }, "child_count": 18, "reference_id": "MONDO:0002529" }, { "id": 4706, "label": "cutaneous Paget disease", "isLeaf": false, "isRoot": false, "parents": [ 4707, 20398 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3450" ], "synonyms": [ "cutaneous Paget's disease", "zone of skin Paget disease" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A skin carcinoma that is characterized by infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli." }, "child_count": 2, "reference_id": "MONDO:0002655" }, { "id": 4946, "label": "anal margin carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4707, 5158 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4284", "GARD:0027626", "MEDGEN:87604", "NCIT:C7472", "UMLS:C0349534" ], "synonyms": [ "anal margin cancer", "anal margin carcinoma", "carcinoma of anal margin", "carcinoma of perianal skin", "carcinoma of the anal margin", "perianal skin carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the perianal skin" }, "child_count": 6, "reference_id": "MONDO:0002941" }, { "id": 5077, "label": "cutaneous mucoepidermoid carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4707, 5029 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4683", "GARD:0023364", "MEDGEN:91072", "NCIT:C4472", "SCTID:254713002", "UMLS:C0346019" ], "synonyms": [ "zone of skin mucoepidermoid carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A mucoepidermoid carcinoma that involves the zone of skin." }, "child_count": 0, "reference_id": "MONDO:0003091" }, { "id": 5740, "label": "eyelid carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4546, 4707, 20495 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6425", "MEDGEN:182526", "NCIT:C6078", "UMLS:C0920196" ], "synonyms": [ "carcinoma of eyelid", "carcinoma of the eyelid", "eyelid carcinoma" ], "categories": [ { "ref": "MONDO:0002022", "name": "disorder of orbital region" }, { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0024458", "name": "disorder of visual system" } ], "definition": "A carcinoma that arises from epithelial cells of the eyelid." }, "child_count": 3, "reference_id": "MONDO:0003876" }, { "id": 5919, "label": "Borst-Jadassohn intraepidermal carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4707 ], "type_id": 0, "properties": { "xrefs": [ "DOID:7039", "ICDO:8096/0", "MEDGEN:424845", "NCIT:C4110", "SCTID:403886007", "UMLS:C2937231" ], "synonyms": [ "intraepidermal epithelioma of Jadassohn" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A rare cutaneous lesion presenting as a scaly verrucous plaque. Morphologically, the plaque contains nests of basaloid cells." }, "child_count": 0, "reference_id": "MONDO:0004083" }, { "id": 6427, "label": "skin carcinoma in situ", "isLeaf": false, "isRoot": false, "parents": [ 4707, 6433 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8687", "ICD10CM:D04", "ICD9:232", "ICD9:232.0", "ICD9:232.2", "ICD9:232.3", "ICD9:232.4", "ICD9:232.5", "ICD9:232.6", "ICD9:232.7", "ICD9:232.8", "ICD9:232.9", "MEDGEN:102308", "NCIT:C3640", "SCTID:92749008", "UMLS:C0154073" ], "synonyms": [ "carcinoma in situ of skin", "carcinoma in situ of the skin", "carcinoma in situ of zone of skin", "carcinoma of skin stage 0", "carcinoma of the skin stage 0", "cutaneous carcinoma in situ", "nonmelanoma carcinoma in situ", "skin cancer stage 0", "skin carcinoma in situ", "skin carcinoma stage 0", "stage 0 nonmelanoma skin carcinoma in situ", "stage 0 skin cancer", "stage 0 skin cancer aJCC v6", "stage 0 skin cancer aJCC v7", "stage 0 skin carcinoma", "stage 0 zone of skin carcinoma", "zone of skin carcinoma in situ", "zone of skin in situ carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A in situ carcinoma that involves the zone of skin." }, "child_count": 2, "reference_id": "MONDO:0004641" }, { "id": 7027, "label": "skin basal cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4707, 20201 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-2719", "DOID:2513", "HP:0002671", "ICDO:8090/3", "MEDGEN:1648304", "NCIT:C2921", "ONCOTREE:BCC", "SCTID:254701007", "UMLS:C4721806" ], "synonyms": [ "BCC", "basal cell cancer", "basal cell carcinoma", "basal cell tumor", "basal cell tumour", "basal cell tumour (morphologic abnormality)", "malignant basal cell tumour", "malignant basal cell tumour (morphologic abnormality)", "basal cell carcinoma of skin", "basal cell carcinoma of the skin", "basal cell epithelioma", "basal cell skin carcinoma", "skin basal cell cancer", "skin basal cell carcinoma", "epithelioma basal cell" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas." }, "child_count": 50, "reference_id": "MONDO:0005341" }, { "id": 8097, "label": "vulvar seborrheic keratosis", "isLeaf": false, "isRoot": false, "parents": [ 4318, 4707, 6931, 9715 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6944", "GARD:0024446", "MEDGEN:237055", "NCIT:C6375", "UMLS:C1336981" ], "synonyms": [ "mammalian vulva seborrheic keratosis", "seborrheic keratosis of mammalian vulva", "seborrheic keratosis of the vulva", "seborrheic keratosis of vulva" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A benign squamous neoplasm that arises from the vulva. It is characterized by the proliferation of the basal cells in the squamous epithelium, acanthosis, hyperkeratosis, and cysts formation." }, "child_count": 4, "reference_id": "MONDO:0006622" }, { "id": 8398, "label": "skin appendage carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4406, 4707 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1001183", "ICDO:8390/3", "MEDGEN:60209", "MESH:D018280", "MedDRA:10040798", "NCIT:C3775", "ONCOTREE:SKAC", "UMLS:C0206697" ], "synonyms": [ "adnexal carcinoma", "carcinoma of adnexa", "carcinoma of cutaneous appendage", "carcinoma of skin appendage", "carcinoma, adnexal, malignant", "cutaneous appendage carcinoma", "skin appendage carcinoma", "skin adnexal carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" } ], "definition": "A carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma." }, "child_count": 6, "reference_id": "MONDO:0006973" }, { "id": 19079, "label": "cutaneous neuroendocrine carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4255, 4707, 5298, 7479, 17658, 20691 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0009266", "ICD10CM:C4A", "ICD9:209.36", "ICDO:8247/3", "MEDGEN:2843", "MESH:D015266", "NCIT:C9231", "NORD:1947", "ONCOTREE:MCC", "Orphanet:79140", "SCTID:253001006", "UMLS:C0007129", "icd11.foundation:680322043" ], "synonyms": [ "MCC", "Merkel Cell Carcinoma", "Merkel cell cancer", "Merkel cell carcinoma", "Merkel cell tumor", "Merkel cell tumour", "carcinoma of Merkel cell", "cutaneous APUDoma", "cutaneous neuroendocrine carcinoma", "neuroendocrine carcinoma of skin", "neuroendocrine carcinoma of the skin", "neuroendocrine skin carcinoma", "trabecular cancer", "trabecular skin carcinoma", "Merkle tumors", "Merkle tumours", "carcinoma, Merkel cell" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Cutaneous neuroendocrine carcinoma is a primary cutaneous cancer arising from a subset of skin neuroendocrine cells (Merkel cells, giving the name Merkel cell carcinoma (MCC))." }, "child_count": 0, "reference_id": "MONDO:0019210" } ], "roots": [ { "id": 4907, "label": "skin cancer" }, { "id": 6734, "label": "carcinoma" }, { "id": 20690, "label": "epithelial skin neoplasm" } ] }