{
  "id": 4708,
  "label": "breast disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002657",
  "properties": {
    "xrefs": [
      "DOID:3463",
      "EFO:0009483",
      "ICD10CM:N60-N65",
      "ICD9:610-612",
      "ICD9:611.8",
      "ICD9:611.9",
      "MEDGEN:652",
      "MESH:D001941",
      "NCIT:C26709",
      "SCTID:79604008",
      "UMLS:C0006145"
    ],
    "synonyms": [
      "breast disease",
      "breast disease or disorder",
      "breast diseases",
      "breast disorder",
      "disease of breast",
      "disease or disorder of breast",
      "disorder of breast"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A disease involving the breast."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 15,
  "parents": [
    {
      "id": 29379,
      "label": "disease by body system or component",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "definition": "A grouping class for human diseases classified by the body system or anatomical component primarily affected."
      },
      "child_count": 19,
      "reference_id": "MONDO:7770006"
    }
  ],
  "children": [
    {
      "id": 3120,
      "label": "breast abscess",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4708,
        6939
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060323",
          "MEDGEN:508760",
          "SCTID:28432003",
          "UMLS:C0151463",
          "icd11.foundation:1033306788"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast disease characterized by a collection of pus in the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000749"
    },
    {
      "id": 3351,
      "label": "hypertrophy of breast",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10688",
          "ICD10CM:N62",
          "ICD10WHO:N62",
          "ICD9:611.1",
          "MEDGEN:43789",
          "NCIT:C3125",
          "SCTID:372281005",
          "UMLS:C0020565",
          "icd11.foundation:2078176266"
        ],
        "synonyms": [
          "breast Hypertrophy",
          "gigantomastia",
          "hypertrophy of the breast",
          "macromastia",
          "drug-induced gigantomastia (subtype)",
          "gestational gigantomastia (subtype)",
          "idiopathic gigantomastia (subtype)",
          "juvenile gigantomastia (subtype)",
          "medication-induced gigantomastia (subtype)",
          "pregnancy-induced gigantomastia (subtype)",
          "puberty-induced gigantomastia (subtype)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Excessive enlargement of one or both breasts. Causes include pregnancy, obesity, and penicillamine therapy. It may result in neck, back, and shoulder pain."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001100"
    },
    {
      "id": 3352,
      "label": "fat necrosis of breast",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10691",
          "ICD10CM:N64.1",
          "ICD9:611.3",
          "MEDGEN:57847",
          "NCIT:C3661",
          "SCTID:21381006",
          "UMLS:C0156321",
          "icd11.foundation:149925294"
        ],
        "synonyms": [
          "breast fat necrosis",
          "fat Necrosis of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Localized necrosis of the adipose tissue in the breast. Clinically, it may present as a mass. Causes include injury, surgical procedures, and radiation treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001101"
    },
    {
      "id": 4207,
      "label": "breast angiomatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3777,
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1637",
          "MEDGEN:307304",
          "NCIT:C40381",
          "UMLS:C1511284"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A benign diffuse vascular proliferation in the breast. It is characterized by the formation of capillary-sized and cavernous vascular spaces."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002064"
    },
    {
      "id": 5605,
      "label": "breast adenosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5998",
          "EFO:0006891",
          "MEDGEN:39336",
          "NCIT:C3484",
          "UMLS:C0085750"
        ],
        "synonyms": [
          "adenosis",
          "adenosis of breast",
          "adenosis of the breast",
          "breast adenosis",
          "microglandular adenosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A non-neoplastic disorder characterized by epithelial and/or myoepithelial tissue growth in the breast lobules. It may be associated with apocrine changes or sclerosis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003725"
    },
    {
      "id": 6571,
      "label": "benign mammary dysplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4198,
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9504",
          "ICD10CM:N60",
          "ICD10WHO:N60",
          "ICD9:610.8",
          "ICD9:610.9",
          "MEDGEN:726820",
          "SCTID:57993004",
          "UMLS:C1305934"
        ],
        "synonyms": [
          "benign mammary dysplasia",
          "benign dysplasia of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004808"
    },
    {
      "id": 6934,
      "label": "breast fibrocystic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10354",
          "EFO:0003014",
          "ICD10CM:N60.1",
          "ICD9:610.1",
          "MEDGEN:42015",
          "MESH:D005348",
          "NCIT:C3039",
          "UMLS:C0016034"
        ],
        "synonyms": [
          "benign breast disease",
          "breast fibrocystic change",
          "cystic disease of breast",
          "cystic disease of the breast",
          "diffuse cystic mastopathy",
          "fibrocystic breast",
          "fibrocystic breast changes",
          "fibrocystic breast disease",
          "fibrocystic change of breast",
          "fibrocystic change of the breast",
          "fibrocystic disease",
          "fibrocystic disease of breast",
          "fibrocystic disease of the breast",
          "fibrocystic mastopathy",
          "mammary dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Fibrosis associated with cyst formation in the breast parenchyma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005219"
    },
    {
      "id": 8293,
      "label": "mastitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10690",
          "EFO:1001034",
          "MEDGEN:9901",
          "MESH:D008413",
          "MedDRA:10026883",
          "NCIT:C53662",
          "SCTID:45198002",
          "UMLS:C0024894"
        ],
        "synonyms": [
          "breast infection",
          "breast inflammation",
          "inflammation of breast",
          "inflammatory disease of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection. Mastitis can also occur in non-breastfeeding women, and rarely in men."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006849"
    },
    {
      "id": 8642,
      "label": "familial juvenile hypertrophy of the breast",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4708,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009450",
          "MEDGEN:140798",
          "MESH:C536821",
          "OMIM:113670",
          "Orphanet:180176",
          "UMLS:C0405471"
        ],
        "synonyms": [
          "familial juvenile gigantomastia",
          "juvenile gigantomastia",
          "juvenile macromastia",
          "virginal breast hypertrophy",
          "virginal mammary hypertrophy",
          "JHB",
          "gigantomastia, juvenile",
          "hypertrophy of the breast, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Familial juvenile hypertrophy of the breast is a rare breast malformation disorder characterized by unilateral or bilateral, symmetrical or asymmetrical, uncontrolled, rapid and massive enlargement of the breast(s) in peripubertal females, occurring in various members of a family. Additional associated manifestations may include skin hyperemia, dilated subcutaneous veins, skin necrosis, kyphosis, lordosis and anonychia. Growth and development are otherwise normal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007237"
    },
    {
      "id": 16592,
      "label": "supernumerary breasts",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020195",
          "MEDGEN:78583",
          "MedDRA:10049786",
          "Orphanet:180182",
          "UMLS:C0266010",
          "icd11.foundation:1458532658"
        ],
        "synonyms": [
          "accessory breasts",
          "polymastia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0015854"
    },
    {
      "id": 16593,
      "label": "isolated congenital breast hypoplasia/aplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009489",
          "MEDGEN:98489",
          "OMIMPS:113700",
          "Orphanet:180188",
          "UMLS:C0432357"
        ],
        "synonyms": [
          "breasts and/or nipples, aplasia or hypoplasia of",
          "isolated congenital amastia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0015855"
    },
    {
      "id": 16594,
      "label": "syndromic breast hypoplasia/aplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020196",
          "MEDGEN:1842220",
          "Orphanet:180193",
          "UMLS:C5680482"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0015856"
    },
    {
      "id": 20340,
      "label": "breast neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708,
        20518
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003869",
          "ICD9:239.3",
          "MEDGEN:264172",
          "MESH:D001943",
          "NCIT:C2910",
          "ONCOTREE:BREAST",
          "SCTID:126926005",
          "UMLS:C1458155"
        ],
        "synonyms": [
          "breast neoplasm",
          "breast neoplasm (disease)",
          "breast tumor",
          "breast tumour",
          "neoplasm of breast",
          "neoplasm of the breast",
          "neoplasm, breast",
          "tumor of breast",
          "tumor of the breast",
          "tumour of breast",
          "tumour of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males."
      },
      "child_count": 22,
      "reference_id": "MONDO:0021100"
    },
    {
      "id": 23515,
      "label": "lactation disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4708,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:5997",
          "SCTID:35046003",
          "UMLS:C0022927"
        ],
        "synonyms": [
          "disorder of lactation",
          "lactation disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0045019"
    },
    {
      "id": 25264,
      "label": "breast implant illness",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        4708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081323"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A syndrome that is characterized by fatigue, problems with memory or concentration, joint and muscle pain, hair loss, weight changes and anxiety/depression. This syndrome may be related to breast implants"
      },
      "child_count": 0,
      "reference_id": "MONDO:0858974"
    }
  ],
  "roots": [
    {
      "id": 29379,
      "label": "disease by body system or component"
    }
  ]
}