{
  "id": 4713,
  "label": "extrahepatic bile duct signet ring cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002664",
  "properties": {
    "xrefs": [
      "DOID:3494",
      "GARD:0023204",
      "MEDGEN:163667",
      "NCIT:C5776",
      "UMLS:C0861859"
    ],
    "synonyms": [
      "bile duct signet Ring cell carcinoma",
      "bile duct signet ring cell carcinoma",
      "extrahepatic bile duct signet Ring cell carcinoma",
      "signet Ring cell bile duct carcinoma",
      "signet Ring cell carcinoma of bile duct",
      "signet Ring cell carcinoma of the bile duct"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of signet ring malignant epithelial cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5152
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3495",
          "GARD:0023205",
          "MEDGEN:124642",
          "NCIT:C7975",
          "UMLS:C0279659"
        ],
        "synonyms": [
          "adenocarcinoma of extrahepatic bile duct",
          "adenocarcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct"
      },
      "child_count": 14,
      "reference_id": "MONDO:0002665"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3493",
          "EFO:0000698",
          "ICDO:8490/3",
          "MEDGEN:61663",
          "MESH:D018279",
          "NCIT:C3774",
          "UMLS:C0206696"
        ],
        "synonyms": [
          "signet ring carcinoma NOS (morphologic abnormality)",
          "signet ring cell adenocarcinoma",
          "signet ring cell carcinoma",
          "signet ring cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005092"
    }
  ],
  "children": [
    {
      "id": 4717,
      "label": "ampullary signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4713,
        4718
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3501",
          "GARD:0023207",
          "MEDGEN:231057",
          "NCIT:C6656",
          "UMLS:C1332249"
        ],
        "synonyms": [
          "ampulla of Vater signet Ring cell carcinoma",
          "ampullary signet Ring cell carcinoma",
          "ampullary signet ring cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the ampulla of Vater. Morphologically, it is characterized by the presence of mucin-containing signet-ring cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002669"
    },
    {
      "id": 6161,
      "label": "signet ring cell intrahepatic cholangiocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4713,
        5166
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7733",
          "GARD:0023949",
          "MEDGEN:276815",
          "NCIT:C41619",
          "UMLS:C1519321"
        ],
        "synonyms": [
          "signet Ring cell intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An intrahepatic cholangiocarcinoma characterized by the presence of signet ring adenocarcinoma cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004346"
    }
  ],
  "roots": [
    {
      "id": 4714,
      "label": "extrahepatic bile duct adenocarcinoma"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma"
    }
  ]
}