{
  "id": 4714,
  "label": "extrahepatic bile duct adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002665",
  "properties": {
    "xrefs": [
      "DOID:3495",
      "GARD:0023205",
      "MEDGEN:124642",
      "NCIT:C7975",
      "UMLS:C0279659"
    ],
    "synonyms": [
      "adenocarcinoma of extrahepatic bile duct",
      "adenocarcinoma of the extrahepatic bile duct",
      "extrahepatic bile duct adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the extrahepatic bile duct"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7152,
        20500
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4682",
          "GARD:0023363",
          "MEDGEN:116036",
          "NCIT:C3860",
          "SCTID:372101000",
          "UMLS:C0238019"
        ],
        "synonyms": [
          "carcinoma of extrahepatic bile duct",
          "carcinoma of the extrahepatic bile duct",
          "extrahepatic bile duct cancer",
          "extrahepatic bile duct carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the extrahepatic bile duct."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003090"
    },
    {
      "id": 5152,
      "label": "bile duct adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        7152
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4896",
          "GARD:0023406",
          "MEDGEN:234585",
          "NCIT:C27813",
          "UMLS:C1370800"
        ],
        "synonyms": [
          "bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the bile duct"
      },
      "child_count": 2,
      "reference_id": "MONDO:0003193"
    }
  ],
  "children": [
    {
      "id": 4713,
      "label": "extrahepatic bile duct signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3494",
          "GARD:0023204",
          "MEDGEN:163667",
          "NCIT:C5776",
          "UMLS:C0861859"
        ],
        "synonyms": [
          "bile duct signet Ring cell carcinoma",
          "bile duct signet ring cell carcinoma",
          "extrahepatic bile duct signet Ring cell carcinoma",
          "signet Ring cell bile duct carcinoma",
          "signet Ring cell carcinoma of bile duct",
          "signet Ring cell carcinoma of the bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of signet ring malignant epithelial cells."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002664"
    },
    {
      "id": 4718,
      "label": "ampulla of vater adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        7742,
        17870
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3502",
          "EFO:0008490",
          "GARD:0023208",
          "MEDGEN:231054",
          "NCIT:C6650",
          "UMLS:C1332243",
          "icd11.foundation:1601321941"
        ],
        "synonyms": [
          "adenocarcinoma of ampulla of Vater",
          "ampulla of Vater adenocarcinoma",
          "ampullary adenocarcinoma",
          "hepatopancreatic ampulla adenocarcinoma",
          "invasive adenocarcinoma of the ampullary region"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the hepatopancreatic ampulla"
      },
      "child_count": 12,
      "reference_id": "MONDO:0002670"
    },
    {
      "id": 4775,
      "label": "extrahepatic bile duct mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3698",
          "GARD:0023226",
          "MEDGEN:167830",
          "NCIT:C5846",
          "UMLS:C0861856"
        ],
        "synonyms": [
          "bile duct colloid carcinoma",
          "bile duct colloidal carcinoma",
          "bile duct mucinous adenocarcinoma",
          "colloid adenocarcinoma of bile duct",
          "colloid adenocarcinoma of extrahepatic bile duct",
          "colloid adenocarcinoma of the bile duct",
          "colloid adenocarcinoma of the extrahepatic bile duct",
          "colloid bile duct adenocarcinoma",
          "colloid bile duct carcinoma",
          "colloid carcinoma of bile duct",
          "colloid carcinoma of the bile duct",
          "colloid extrahepatic bile duct adenocarcinoma",
          "colloidal adenocarcinoma of bile duct",
          "colloidal adenocarcinoma of extrahepatic bile duct",
          "colloidal adenocarcinoma of the bile duct",
          "colloidal adenocarcinoma of the extrahepatic bile duct",
          "colloidal bile duct adenocarcinoma",
          "colloidal bile duct carcinoma",
          "colloidal carcinoma of bile duct",
          "colloidal carcinoma of the bile duct",
          "colloidal extrahepatic bile duct adenocarcinoma",
          "extrahepatic bile duct mucinous adenocarcinoma",
          "mucinous adenocarcinoma of bile duct",
          "mucinous adenocarcinoma of extrahepatic bile duct",
          "mucinous adenocarcinoma of the bile duct",
          "mucinous adenocarcinoma of the extrahepatic bile duct",
          "mucinous bile duct adenocarcinoma",
          "mucinous carcinoma of bile duct",
          "mucinous carcinoma of the bile duct",
          "mucinous extrahepatic bile duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of extracellular mucin that constitutes more than fifty-percent of the tumor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002739"
    },
    {
      "id": 5590,
      "label": "extrahepatic bile duct small cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        4714,
        16046
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5926",
          "GARD:0023628",
          "MEDGEN:277648",
          "NCIT:C5845",
          "UMLS:C1335979"
        ],
        "synonyms": [
          "Oat cell carcinoma of extrahepatic bile duct",
          "Oat cell carcinoma of the extrahepatic bile duct",
          "Oat cell extrahepatic bile duct carcinoma",
          "extrahepatic bile duct small cell NEC",
          "extrahepatic bile duct small cell neuroendocrine carcinoma",
          "small cell adenocarcinoma of extrahepatic bile duct",
          "small cell adenocarcinoma of the extrahepatic bile duct",
          "small cell extrahepatic bile duct carcinoma",
          "small cell extrahepatic bile duct neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It is characterized by the presence of malignant small cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003708"
    },
    {
      "id": 5880,
      "label": "papillary extrahepatic bile duct adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6931",
          "GARD:0023788",
          "MEDGEN:167831",
          "UMLS:C0861858"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004039"
    },
    {
      "id": 5917,
      "label": "extrahepatic bile duct clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6742
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7032",
          "GARD:0023808",
          "MEDGEN:167829",
          "NCIT:C5775",
          "UMLS:C0861855"
        ],
        "synonyms": [
          "bile duct clear cell adenocarcinoma",
          "clear cell adenocarcinoma of bile duct",
          "clear cell adenocarcinoma of the bile duct",
          "clear cell bile duct adenocarcinoma",
          "extrahepatic bile duct clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of extrahepatic bile duct adenocarcinoma characterized by the presence of malignant glandular epithelium composed of clear cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004081"
    },
    {
      "id": 18555,
      "label": "adenocarcinoma of gallbladder and extrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        18842
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021791",
          "MEDGEN:1633887",
          "Orphanet:424991",
          "SCTID:765741003",
          "UMLS:C4707555"
        ],
        "synonyms": [
          "adenocarcinoma of gallbladder and EBT",
          "adenocarcinoma of the gallbladder and EBT",
          "adenocarcinoma of the gallbladder and extrahepatic biliary tract"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Adenocarcinoma of the gallbladder and extrahepatic biliary tract is a rare epithelial carcinoma, arising either in the gallbladder itself or from the epithelium lining the extrahepatic biliary tree, cystic duct and/or peribiliary gland, characterized by nonspecific symptoms, such as abdominal pain, jaundice and vomiting and sometimes mimicking benign biliary diseases. Chronic biliary epithelial inflammation (e.g. primary sclerosing cholangitis, cholelithiasis, choledocholithiasis, liver fluke infestation) is a major risk factor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018536"
    }
  ],
  "roots": [
    {
      "id": 5076,
      "label": "extrahepatic bile duct carcinoma"
    },
    {
      "id": 5152,
      "label": "bile duct adenocarcinoma"
    }
  ]
}