{
  "id": 4715,
  "label": "pancreatic signet ring cell adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002666",
  "properties": {
    "xrefs": [
      "DOID:3497",
      "GARD:0027610",
      "MEDGEN:233834",
      "NCIT:C5720",
      "UMLS:C1335317"
    ],
    "synonyms": [
      "pancreas signet ring cell carcinoma",
      "pancreatic signet Ring cell carcinoma",
      "pancreatic signet ring cell carcinoma",
      "signet Ring cell carcinoma of pancreas",
      "signet Ring cell carcinoma of the pancreas"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A rare pancreatic ductal adenocarcinoma with poor prognosis. It is characterized by the presence of malignant signet ring cells infiltrating the pancreatic parenchyma in an individual cell pattern."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6819,
      "label": "signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3493",
          "EFO:0000698",
          "ICDO:8490/3",
          "MEDGEN:61663",
          "MESH:D018279",
          "NCIT:C3774",
          "UMLS:C0206696"
        ],
        "synonyms": [
          "signet ring carcinoma NOS (morphologic abnormality)",
          "signet ring cell adenocarcinoma",
          "signet ring cell carcinoma",
          "signet ring cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005092"
    },
    {
      "id": 6905,
      "label": "pancreatic ductal adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7247,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3498",
          "DOID:3587",
          "EFO:0002517",
          "GARD:0027716",
          "ICD9:157.3",
          "MEDGEN:277490",
          "MESH:D021441",
          "NCIT:C9120",
          "UMLS:C1335302",
          "icd11.foundation:581089833"
        ],
        "synonyms": [
          "ductal adenocarcinoma of pancreas",
          "ductal adenocarcinoma of the pancreas",
          "pancreas ductal adenocarcinoma",
          "pancreas tubular adenocarcinoma",
          "pancreatic duct adenocarcinoma",
          "pancreatic ductal adenocarcinoma",
          "pancreatic ductal carcinoma",
          "pancreatic tubular adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005184"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6819,
      "label": "signet ring cell carcinoma"
    },
    {
      "id": 6905,
      "label": "pancreatic ductal adenocarcinoma"
    }
  ]
}