{
  "id": 4719,
  "label": "signet ring cell breast carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002671",
  "properties": {
    "xrefs": [
      "DOID:3503",
      "MEDGEN:236816",
      "NCIT:C5175",
      "ONCOTREE:BRSRCC",
      "UMLS:C1335964"
    ],
    "synonyms": [
      "SRC breast carcinoma",
      "SRC carcinoma of breast",
      "SRC carcinoma of the breast",
      "breast signet ring cell carcinoma",
      "mammary signet Ring cell carcinoma",
      "primary SRC breast carcinoma",
      "primary SRC carcinoma of breast",
      "primary SRC carcinoma of the breast",
      "primary mammary signet Ring cell carcinoma",
      "primary signet Ring cell breast carcinoma",
      "primary signet Ring cell carcinoma of breast",
      "primary signet Ring cell carcinoma of the breast",
      "signet Ring cell breast carcinoma",
      "signet Ring cell carcinoma of breast",
      "signet Ring cell carcinoma of the breast",
      "breast carcinoma with signet ring",
      "breast signet ring cell adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6712,
        6730
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3458",
          "EFO:0000304",
          "MEDGEN:167809",
          "NCIT:C5214",
          "UMLS:C0858252"
        ],
        "synonyms": [
          "adenocarcinoma of breast",
          "adenocarcinoma of the breast",
          "breast adenocarcinoma",
          "mammary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the breast"
      },
      "child_count": 39,
      "reference_id": "MONDO:0004988"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3493",
          "EFO:0000698",
          "ICDO:8490/3",
          "MEDGEN:61663",
          "MESH:D018279",
          "NCIT:C3774",
          "UMLS:C0206696"
        ],
        "synonyms": [
          "signet ring carcinoma NOS (morphologic abnormality)",
          "signet ring cell adenocarcinoma",
          "signet ring cell carcinoma",
          "signet ring cell carcinoma (morphologic abnormality)"
        ],
        "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005092"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6730,
        23004
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000307",
          "MEDGEN:163435",
          "NCIT:C9245",
          "ONCOTREE:BRCA",
          "SCTID:713609000",
          "UMLS:C0853879",
          "icd11.foundation:2090549892"
        ],
        "synonyms": [
          "infiltrating breast cancer",
          "infiltrating breast carcinoma",
          "infiltrating carcinoma of breast",
          "infiltrating carcinoma of the breast",
          "invasive breast cancer",
          "invasive breast carcinoma",
          "invasive carcinoma of breast",
          "invasive carcinoma of the breast",
          "invasive mammary carcinoma",
          "BRCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that infiltrates the breast parenchyma. The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU). Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ. It is the most common carcinoma affecting women."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006256"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6729,
      "label": "breast adenocarcinoma"
    },
    {
      "id": 6819,
      "label": "signet ring cell carcinoma"
    },
    {
      "id": 7803,
      "label": "invasive breast carcinoma"
    }
  ]
}