{
  "id": 4735,
  "label": "liver cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002691",
  "properties": {
    "xrefs": [
      "DOID:3571",
      "GARD:0027613",
      "ICD9:155.0",
      "ICD9:155.2",
      "MEDGEN:87520",
      "NCIT:C34803",
      "SCTID:93870000",
      "UMLS:C0345904",
      "icd11.foundation:1605020868"
    ],
    "synonyms": [
      "cancer of liver",
      "hepatic cancer",
      "liver cancer",
      "malignant liver neoplasm",
      "malignant neoplasm of liver",
      "malignant neoplasm of liver, not specified as primary or secondary",
      "malignant neoplasm of liver, primary",
      "malignant tumour of liver",
      "primary liver cancer",
      "primary malignant liver neoplasm",
      "primary malignant neoplasm of liver",
      "primary cancer of liver",
      "primary tumor of the liver",
      "primary tumour of the liver"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An epithelial or non-epithelial malignant neoplasm that arises from the liver. Representative examples include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, lymphoma, and sarcoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4587,
      "label": "digestive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        6733,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3119",
          "ICD10CM:C15-C26",
          "ICD9:239.0",
          "MEDGEN:148231",
          "NCIT:C4890",
          "UMLS:C0751075"
        ],
        "synonyms": [
          "GI tumor",
          "GI tumour",
          "cancer of digestive system",
          "digestive system cancer",
          "gastrointestinal system cancer",
          "malignant digestive system neoplasm",
          "malignant gastrointestinal neoplasm",
          "malignant gastrointestinal system neoplasm",
          "malignant neoplasm of digestive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving any part of the digestive system."
      },
      "child_count": 45,
      "reference_id": "MONDO:0002516"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    },
    {
      "id": 21432,
      "label": "liver and intrahepatic bile duct neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4585,
        6878
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:916",
          "MEDGEN:232599",
          "NCIT:C7103",
          "NCIT:C7106",
          "ONCOTREE:LIVER",
          "SCTID:126851005",
          "UMLS:C1333976"
        ],
        "synonyms": [
          "epithelial hepatic and intrahepatic bile duct neoplasm",
          "hepatic and intrahepatic bile duct neoplasm",
          "liver and intrahepatic bile duct epithelial neoplasm",
          "liver and intrahepatic bile duct neoplasm",
          "liver neoplasm",
          "liver neoplasm (disease)",
          "liver tumor",
          "liver tumour",
          "neoplasm of liver",
          "tumor of liver",
          "tumour of liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the liver parenchyma or intrahepatic bile ducts. Representative examples of benign neoplasms include hepatocellular adenoma, and bile duct adenoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and lymphoma."
      },
      "child_count": 51,
      "reference_id": "MONDO:0024477"
    }
  ],
  "children": [
    {
      "id": 4487,
      "label": "liver sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:270",
          "GARD:0023130",
          "MEDGEN:87522",
          "NCIT:C4437",
          "SCTID:254601002",
          "UMLS:C0345906"
        ],
        "synonyms": [
          "hepatic sarcoma",
          "liver sarcoma",
          "sarcoma of liver",
          "sarcoma of the liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant soft tissue neoplasm that arises from the liver. Representative examples include angiosarcoma, undifferentiated (embryonal) sarcoma, rhabdomyosarcoma, and leiomyosarcoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002397"
    },
    {
      "id": 5050,
      "label": "biliary tract cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        6998
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4607",
          "GARD:0005924",
          "ICD9:156.9",
          "MEDGEN:155474",
          "UMLS:C0750952"
        ],
        "synonyms": [
          "biliary tree cancer",
          "cancer of biliary tree",
          "malignant biliary tree neoplasm",
          "malignant neoplasm of biliary tree",
          "malignant tumor of biliary tract"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the biliary tree"
      },
      "child_count": 4,
      "reference_id": "MONDO:0003060"
    },
    {
      "id": 6475,
      "label": "liver lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        6479
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:901",
          "GARD:0024089",
          "MEDGEN:207276",
          "NCIT:C4949",
          "UMLS:C1112746"
        ],
        "synonyms": [
          "hepatic lymphoma",
          "liver lymphoma",
          "lymphoma of liver",
          "lymphoma of the liver",
          "primary hepatic lymphoma",
          "primary liver lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare lymphoma that arises from the liver and the bulk of the tumor is located in the liver. The most frequent types of lymphoma that arise from the liver are diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004695"
    },
    {
      "id": 7690,
      "label": "calcifying nested epithelial stromal tumor of the liver",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4735
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000149",
          "GARD:0027741",
          "ICDO:8975/1",
          "MEDGEN:758637",
          "NCIT:C96830",
          "UMLS:C3472610"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant tumor that arises from the liver and occurs in children. It is characterized by the presence of nested epithelioid and spindle cells. Desmoplasia, calcifications, and bone formation may also be present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006122"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021786",
          "MEDGEN:78921",
          "NCIT:C7927",
          "ONCOTREE:HCCIHCH",
          "Orphanet:424936",
          "UMLS:C0279000"
        ],
        "synonyms": [
          "cancer of liver",
          "cancer of liver and intrahepatic biliary tract",
          "cancer of the liver",
          "cancer of the liver and intrahepatic biliary tract",
          "carcinoma of liver",
          "hepatic cancer",
          "liver and intrahepatic bile duct cancer",
          "liver cancer",
          "liver carcinoma",
          "liver/hepatobiliary cancer",
          "carcinoma of liver and IBT",
          "liver and intrahepatic bile duct carcinoma",
          "liver and intrahepatic biliary tract cancer",
          "liver and intrahepatic biliary tract carcinoma",
          "primary liver carcinoma",
          "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018531"
    }
  ],
  "roots": [
    {
      "id": 4587,
      "label": "digestive system cancer"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    },
    {
      "id": 21432,
      "label": "liver and intrahepatic bile duct neoplasm"
    }
  ]
}