{
  "id": 4736,
  "label": "intracranial sinus thrombosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002692",
  "properties": {
    "xrefs": [
      "DOID:3572",
      "MEDGEN:20771",
      "MESH:D012851",
      "UMLS:C0037198"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Formation or presence of a blood clot (thrombus) in the cranial sinuses, large endothelium-lined venous channels situated within the skull. Intracranial sinuses, also called cranial venous sinuses, include the superior sagittal, cavernous, lateral, petrous sinuses, and many others. Cranial sinus thrombosis can lead to severe headache; seizure; and other neurological defects."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4914,
      "label": "intracranial thrombosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3150,
        12183
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4193",
          "ICD9:434.0",
          "ICD9:434.00",
          "MEDGEN:199820",
          "MESH:D020767",
          "SCTID:71444005",
          "UMLS:C0752143"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Formation or presence of a blood clot (thrombus) in a blood vessel within the skull. Intracranial thrombosis can lead to thrombotic occlusions and brain infarction. The majority of the thrombotic occlusions are associated with atherosclerosis."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002907"
    }
  ],
  "children": [
    {
      "id": 4737,
      "label": "lateral sinus thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3574",
          "MEDGEN:124359",
          "MESH:D020227",
          "SCTID:192761004",
          "UMLS:C0270639"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Formation or presence of a blood clot (thrombus) in the lateral sinuses. This condition is often associated with ear infections (otitis media or mastoiditis) without antibiotic treatment. In developed nations, lateral sinus thrombosis can result from craniocerebral trauma; brain neoplasms; neurosurgical procedures; thrombophilia; and other conditions. Clinical features include headache; vertigo; and increased intracranial pressure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002693"
    },
    {
      "id": 4738,
      "label": "cavernous sinus thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3575",
          "MEDGEN:65970",
          "MESH:D020226",
          "SCTID:89980009",
          "UMLS:C0238454"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Formation or presence of a blood clot (thrombus) in the cavernous sinus of the brain. Infections of the paranasal sinuses and adjacent structures, craniocerebral trauma, and thrombophilia are associated conditions. Clinical manifestations include dysfunction of cranial nerves iii, iv, V, and vi, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0002694"
    },
    {
      "id": 4739,
      "label": "sagittal sinus thrombosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3576",
          "MEDGEN:90927",
          "MESH:D020225",
          "SCTID:192760003",
          "UMLS:C0338575"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Formation or presence of a blood clot (thrombus) in the superior sagittal sinus or the inferior sagittal sinus. Sagittal sinus thrombosis can result from infections, hematological disorders, craniocerebral trauma; and neurosurgical procedures. Clinical features are primarily related to the increased intracranial pressure causing headache; nausea; and vomiting. Severe cases can evolve to seizures or coma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002695"
    }
  ],
  "roots": [
    {
      "id": 4914,
      "label": "intracranial thrombosis"
    }
  ]
}