{
  "id": 4741,
  "label": "ovarian gonadoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002697",
  "properties": {
    "xrefs": [
      "DOID:3578",
      "GARD:0017100",
      "HP:0000149",
      "MEDGEN:309510",
      "NCIT:C39985",
      "OMIM:424500",
      "Orphanet:206484",
      "SCTID:716594002",
      "UMLS:C1518716",
      "icd11.foundation:1564602847"
    ],
    "synonyms": [
      "GBY",
      "gonadoblastoma",
      "gonadoblastoma of ovary",
      "ovarian gonadoblastoma",
      "ovarian gonadoblastoma (disease)",
      "ovary gonadoblastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm that arises from the ovary and is composed of tissues that resemble dysgerminoma or seminoma and are admixed with sex cord tissues. It is found in children or young adults and usually is associated with secondary sex organs abnormalities. The majority of patients present as phenotypic females with virilization. The minority of patients present as phenotypic males with feminization. It typically affects both gonads. If a malignant germ cell component is present, it may metastasize to other anatomic sites."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 11906,
      "label": "gonadoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        4375,
        4558,
        7213,
        7464,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3301",
          "ICDO:9073/1",
          "MEDGEN:104912",
          "MESH:D018238",
          "NCIT:C3754",
          "ONCOTREE:OGBL",
          "UMLS:C0206661"
        ],
        "synonyms": [
          "gonad blastoma",
          "gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010768"
    },
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18448,
        20709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018816",
          "MEDGEN:233667",
          "NCIT:C8053",
          "Orphanet:35808",
          "UMLS:C1334609"
        ],
        "synonyms": [
          "malignant Sex cord-stromal tumor of ovary",
          "malignant Sex cord-stromal tumor of the ovary",
          "malignant Sex cord-stromal tumour of ovary",
          "malignant Sex cord-stromal tumour of the ovary",
          "malignant ovarian SCST",
          "malignant ovarian Sex cord-stromal neoplasm",
          "malignant ovarian Sex cord-stromal tumor",
          "malignant ovarian Sex cord-stromal tumour",
          "malignant ovarian sex cord-stromal tumor",
          "malignant ovarian sex cord-stromal tumour",
          "ovarian sex cord-stromal tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant sex cord stromal tumor (SCST) of ovary is a rare ovarian cancer arising from granulosa, theca, sertoli and leydig cells or stromal fibroblasts, occurring at any age and presenting with abdominal or pelvic mass, and characterized (with the exception of fibroma) by the production of sex steroids resulting in manifestations of hormone excess, with a relatively favorable prognosis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0018172"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 11906,
      "label": "gonadoblastoma"
    },
    {
      "id": 18316,
      "label": "malignant sex cord stromal tumor of ovary"
    }
  ]
}