{
  "id": 4742,
  "label": "testicular gonadoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002698",
  "properties": {
    "xrefs": [
      "DOID:3579",
      "GARD:0023215",
      "HP:0000030",
      "MEDGEN:272839",
      "NCIT:C39911",
      "UMLS:C1515283"
    ],
    "synonyms": [
      "gonadoblastoma of testis",
      "testicular gonadoblastoma",
      "testicular gonadoblastoma (disease)",
      "testis gonadoblastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A testicular mixed germ cell-sex cord-stromal tumor. It is usually associated with mixed gonadal dysgenesis and ambiguous genitalia. It is characterized by the presence of nests of large neoplastic germ cells and immature cells that resemble Sertoli cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7639,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4757",
          "GARD:0021551",
          "MEDGEN:825921",
          "NCIT:C6358",
          "Orphanet:363489",
          "SCTID:702406000",
          "UMLS:C3840076"
        ],
        "synonyms": [
          "sex cord-stromal tumor of testis",
          "sex cord-stromal tumour of testis",
          "testicular sex cord-stromal neoplasm",
          "testicular sex cord-stromal tumor",
          "testicular sex cord-stromal tumour",
          "testis sex cord-stromal tumor",
          "testis sex cord-stromal tumour",
          "sex cord-stromal neoplasm",
          "sex cord-stromal neoplasm of testis",
          "sex cord-stromal neoplasm of the testis",
          "sex cord-stromal tumor of the testis",
          "sex cord-stromal tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant tumor that arises from the testis. It is composed of granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. Each of these cell types may constitute the only cellular component that is present in the tumor or it may be mixed with other cell types in various combinations. The prognosis can not always be predicted on histologic grounds alone. Approximately, ten percent of these tumors may metastasize. Representative examples include granulosa cell tumor, Leydig cell tumor, Sertoli cell tumor, and tumors of the thecoma-fibroma group."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003125"
    },
    {
      "id": 7111,
      "label": "testicular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2998",
          "EFO:0005088",
          "ICD10CM:C62",
          "ICD9:186",
          "ICD9:186.9",
          "MEDGEN:56313",
          "MESH:D013736",
          "NCIT:C7251",
          "SCTID:363449006",
          "UMLS:C0153594"
        ],
        "synonyms": [
          "testicular tumor",
          "testicular tumour",
          "testis neoplasm",
          "cancer of testis",
          "malignant neoplasm of testis",
          "malignant neoplasm of the testis",
          "malignant testicular neoplasm",
          "malignant testicular tumor",
          "malignant testicular tumour",
          "malignant testis neoplasm",
          "malignant tumor of testis",
          "malignant tumor of the testis",
          "malignant tumour of testis",
          "malignant tumour of the testis",
          "testis cancer",
          "paediatric testicular neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005447"
    },
    {
      "id": 11906,
      "label": "gonadoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        4375,
        4558,
        7213,
        7464,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3301",
          "ICDO:9073/1",
          "MEDGEN:104912",
          "MESH:D018238",
          "NCIT:C3754",
          "ONCOTREE:OGBL",
          "UMLS:C0206661"
        ],
        "synonyms": [
          "gonad blastoma",
          "gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010768"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5102,
      "label": "testicular sex cord-stromal neoplasm"
    },
    {
      "id": 7111,
      "label": "testicular cancer"
    },
    {
      "id": 11906,
      "label": "gonadoblastoma"
    }
  ]
}